Crystallization Selectivity of Ribavirin Solution and Amorphous Phase

Abstract

Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and DMSO solution are compared via mid-frequency Raman difference spectra (MFRDS). The crystallization process from amorphous ribavirin to Form I and from solution to amorphous phase is explained. Reasons for the difficulty in preparing the DMSO solvate are proposed. The rationale provided for the crystallization selectivity provides a foundation for the synthesis of metastable phases with a robust and convenient method.

Fabrication and evaluation of ribavirin-loaded electrospun nanofibers as an antimicrobial wound dressing

“…Ribavirin XRD diffractogram in its solid form ( Fig. 3 ) showed a pattern of Bragg reflections similar to reported results by Li et al, (2023) . The absence of reflections suggests that the polymer is in amorphous form, which is in agreement with ( Aburayan et al, 2020 ) Aburayan et al, 2020 , Alkahtani et al, 2021 .…”

New Findings on the Crystal Polymorphism of Imepitoin

“…Sometimes it is difficult to reproduce the formation of a certain polymorph even when the same experimental procedure that had previously produced it is followed to the letter. Therefore, even today, we must recognize the validity of the famous phrase of McCrone formulated in 1965: "every compound has different polymorphic forms, and, in general, the number of forms known for a given compound is proportional to the time and money spent in research on that compound" [9,10].…”