Crystallo-co-spray drying as a new approach to manufacturing of drug/excipient agglomerates: Impact of processing on the properties of paracetamol and lactose mixtures

Abstract

The novel process of crystallo-co-spray drying of paracetamol and α-lactose monohydrate was investigated by varying the spray dryer inlet temperature and inlet feed solvent composition. A crystalline agglomerate was obtained with no change to the physical structure of either component throughout both investigations and with possible interactions between the hydroxyl groups of the αlactose monohydrate and the amide and hydroxyl groups of the paracetamol detected. The percentage soluble fraction of the components in the inlet feed had the largest influence on the morphology of the final dried agglomerate. Low excipient soluble fraction resulted in an increase in paracetamol surface coating and high excipient soluble fraction produced agglomerates of highly mixed components. The use of crystallo-co-spray drying can serve as a method of producing an agglomerated blend of crystalline co-spray dried components leading to possible opportunities for process intensification with the reduction of process steps such as blending, agglomeration, drying and milling into one single stage.

The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose

“…while all other lactose samples showed no absorption peak at all. It is also very interesting that all samples have a peak near at 1654 cm −1 , which respectively represents the bending vibration of the hydroxyl groups of the crystalline water for Lactose (1650 cm −1 ) [39], and C = C stretching vibration in alkene bonds for PVP K30 [40], besides Lactose-0. That's because Lactose-0 loses the crystalline water after the spray-drying process.…”

Preparation and Evaluation of Silymarin‐Loaded Solid Eutectic for Enhanced Anti‐Inflammatory, Hepatoprotective Effect: In Vitro–In Vivo Prospect

“…A strong band at 1290 cm −1 was observed due to the in-plane OH bending vibration and interestingly involved in the interaction. The interaction may drop the crystallinity of phytoconstituent [ 32 ]. A small band at 1072 cm −1 emerges due to C-O stretching vibration.…”