2018
DOI: 10.1212/wnl.0000000000006383
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CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum

Abstract: ObjectiveTo investigate the clinical utility of 3 CSF biomarkers along the clinical spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).MethodsWe analyzed 3 CSF biomarkers: the soluble β-fragment of amyloid precursor protein (sAPPβ), YKL-40, and neurofilament light (NfL) in FTD (n = 86), ALS (n = 38), and a group of age-matched cognitively normal controls (n = 49). Participants with FTD with a CSF profile of Alzheimer disease were excluded. We compared cross-sectional biomarker le… Show more

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Cited by 67 publications
(86 citation statements)
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“…Twenty-six studies compared CSF NfL concentration in 1827 FTD cases and 1113 cognitively unimpaired controls, with a ROM of 3.41 (95% CI 2.96-3.93, P , 0.0001; Fig. 3A) [16][17][18][20][21][22][26][27][28]31,32,35,36,38,[44][45][46][54][55][56][57][58][59][60][61][62]. Four studies investigated 113 FTD cases and 110 MCI controls [9,22,43,44], with no observable difference in CSF NfL concentration (ROM 5 1.87, 95% CI 0.88-3.98, P 5 0.077; Fig.…”
Section: Nfl In Ftdmentioning
confidence: 99%
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“…Twenty-six studies compared CSF NfL concentration in 1827 FTD cases and 1113 cognitively unimpaired controls, with a ROM of 3.41 (95% CI 2.96-3.93, P , 0.0001; Fig. 3A) [16][17][18][20][21][22][26][27][28]31,32,35,36,38,[44][45][46][54][55][56][57][58][59][60][61][62]. Four studies investigated 113 FTD cases and 110 MCI controls [9,22,43,44], with no observable difference in CSF NfL concentration (ROM 5 1.87, 95% CI 0.88-3.98, P 5 0.077; Fig.…”
Section: Nfl In Ftdmentioning
confidence: 99%
“…Sixteen studies investigated CSF NfL concentration in 930 ALS cases compared with 593 cognitively unimpaired controls [4,27,34,41,[57][58][59][64][65][66][67][68][69][70][71], with an average CSF NfL concentration ratio of 9.64 (95% CI 6.65-13.99, P , 0.0001; Fig. 4A).…”
Section: Nfl In Alsmentioning
confidence: 99%
“…Other CSF biomarkers are being studied in AD and other neurodegenerative dementias. Neurofilament light (NF‐L) is a major cytoskeletal constituent of neuronal cells and can be released into the CSF, detecting significant increases in different neurologic disorders . Neurogranin (Ng) is a calmodulin‐binding postsynaptic neuronal protein that is abundantly expressed in perikaryal and dendritic cytoplasm, involved in modulating synaptic transmission and plasticity mechanisms .…”
Section: Introductionmentioning
confidence: 99%
“…YKL‐40 is a glycoprotein produced by inflammatory cells, mostly astrocytes. Its physiological role is not completely understood but YKL‐40 is increased in the brain and CSF in several neurologic and neurodegenerative diseases associated with inflammatory processes …”
Section: Introductionmentioning
confidence: 99%
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