CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Alz & Dem Diag Ass & Dis Mo

Schütze

et al. 2019

Self Cite

Introduction Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable. Methods We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. Results We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. Discussion Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Bainbridge

Alz & Dem Diag Ass & Dis Mo

Schütze

et al. 2019

Self Cite

“…In future work, investigating the neural fate of memorable and forgettable images in older individuals and those with SCD or MCI may aid in understanding how patients may differentially process images at different processing stages of perception and memory encoding. In the DELCODE study, we have indeed obtained fMRI data alongside the behavioral data reported here [11] and will be able to address this question in the future. A related question is how Alzheimer’s pathology is related to memorability.…”

Section: Discussionmentioning

confidence: 99%

“…Visual memory tests were analyzed from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE), an observational, longitudinal memory clinic-based study across 10 sites in Germany. Specific details about this study, the visual memory task, and data handling and quality control are reported in Jessen et al [10] and Düzel et al [11]. The data analyzed in this study were from the second data release from the DELCODE study comprising of 700 individuals of which 394 participants with complete datasets were analyzed, including 136 participants with SCD, 65 with MCI, and 193 HC.…”

Section: Methodsmentioning

confidence: 99%

Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment

Bainbridge

Schütze

et al. 2019

Preprint

Self Cite

INTRODUCTIONImpaired long-term memory is a defining feature of Mild Cognitive Impairment (MCI). We tested whether this impairment is item-specific, limited to some memoranda whereas some remain consistently memorable.METHODSWe conducted item-based analyses of long-term visual recognition memory. 394 participants (healthy controls (HC), Subjective Cognitive Decline (SCD), and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs.RESULTSWe observed consistent memorability for images in HCs, SCDs, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set.DISCUSSIONIndividuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

Current advances in digital cognitive assessment for preclinical Alzheimer's disease

Öhman

Hassenstab

Alz & Dem Diag Ass & Dis Mo

et al. 2021

Self Cite

105

102

There is a pressing need to capture and track subtle cognitive change at the preclinical stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity. Concurrently, the landscape of digital cognitive assessment is rapidly evolving as technology advances, older adult tech‐adoption increases, and external events (i.e., COVID‐19) necessitate remote digital assessment. Here, we provide a snapshot review of the current state of digital cognitive assessment for preclinical AD including different device platforms/assessment approaches, levels of validation, and implementation challenges. We focus on articles, grants, and recent conference proceedings specifically querying the relationship between digital cognitive assessments and established biomarkers for preclinical AD (e.g., amyloid beta and tau) in clinically normal (CN) individuals. Several digital assessments were identified across platforms (e.g., digital pens, smartphones). Digital assessments varied by intended setting (e.g., remote vs. in‐clinic), level of supervision (e.g., self vs. supervised), and device origin (personal vs. study‐provided). At least 11 publications characterize digital cognitive assessment against AD biomarkers among CN. First available data demonstrate promising validity of this approach against both conventional assessment methods (moderate to large effect sizes) and relevant biomarkers (predominantly weak to moderate effect sizes). We discuss levels of validation and issues relating to usability, data quality, data protection, and attrition. While still in its infancy, digital cognitive assessment, especially when administered remotely, will undoubtedly play a major future role in screening for and tracking preclinical AD.