CSMD1 Mutation Related to Immunity Can Be Used as a Marker to Evaluate the Clinical Therapeutic Effect and Prognosis of Patients with Esophageal Cancer

Fan, Xin; Song, Jianxiong; Fan, Yixuan; Li, Jiaqi; Zhu, Huanhuan; Zhang, Zhiyuan

doi:10.2147/ijgm.s338284

Cited by 12 publications

(13 citation statements)

References 61 publications

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“…In all statistical methods, results at p < 0.05 were considered statistically significant unless otherwise stated. We used the student’s t-test or non-parametric test to compare differences between continuous variables and the chi-square test or Fisher’s exact test to compare differences between categorical variables ( Fan et al, 2021 ). Prognosis-related differentially expressed immune-related genes (PR-DE-IRGs) and prognosis-related differentially expressed ferroptosis-related genes (PR-DE-FRGs) were identified using univariate cox regression analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The difference in Survival Probability between subgroups were compared using Kaplan-Meier analysis and log-rank test. Univariate and multivariate Cox analyses based on each clinical feature and risk score were used to verify the independent prognostic value of risk score ( Fan et al, 2021 ). Correlation between variables was examined by Spearman or Pearson correlation analysis.…”

Section: Methodsmentioning

confidence: 99%

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Identification of immune-related ferroptosis prognostic marker and in-depth bioinformatics exploration of multi-omics mechanisms in thyroid cancer

Fan

Xie

Zhang

et al. 2022

Front. Mol. Biosci.

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Background: Factors such as variations in thyroid carcinoma (THCA) gene characteristics could influence the clinical outcome. Ferroptosis and immunity have been verified to play an essential role in various cancers, and could affect the cancer patients’ prognosis. However, their relationship to the progression and prognosis of many types of THCA remains unclear.Methods: First, we extracted prognosis-related immune-related genes and ferroptosis-related genes from 2 databases for co-expression analysis to obtain prognosis-related differentially expressed immune-related ferroptosis genes (PR-DE-IRFeGs), and screened BID and CDKN2A for building a prognostic model. Subsequently, multiple validation methods were used to test the model’s performance and compare its performance with other 4 external models. Then, we explored the mechanism of immunity and ferroptosis in the occurrence, development and prognosis of THCA from the perspectives of anti-tumor immunity, CDKN2A-related competitive endogenous RNA regulatory, copy number variations and high frequency gene mutation. Finally, we evaluated this model’s clinical practice value.Results: BID and CDKN2A were identified as prognostic risk and protective factors, respectively. External data and qRT-PCR experiment also validated their differential expression. The model’s excellent performance has been repeatedly verified and outperformed other models. Risk scores were significantly associated with most immune cells/functions. Risk score/2 PR-DE-IRFeGs expression was strongly associated with BRAF/NRAS/HRAS mutation. Single copy number deletion of CDKN2A is associated with upregulation of CDKN2A expression and worse prognosis. The predicted regulatory network consisting of CYTOR, hsa-miRNA-873-5p and CDKN2A was shown to significantly affect prognosis. The model and corresponding nomogram have been shown to have excellent clinical practice value.Conclusion: The model can effectively predict the THCA patients’ prognosis and guide clinical treatment. Ferroptosis and immunity may be involved in the THCA’s progression through antitumor immunity and BRAF/NRAS/HRAS mutation. CYTOR-hsa-miRNA-873-5p-CDKN2A regulatory networks and single copy number deletion of CDKN2A may also affect THCA′ progression and prognosis.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Identification of immune-related ferroptosis prognostic marker and in-depth bioinformatics exploration of multi-omics mechanisms in thyroid cancer

Fan

Xie

Zhang

et al. 2022

Front. Mol. Biosci.

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“…In the present study, SRR was found to have positive correlations with TMB and MSI in UCEC. Furthermore, the correlations between SRR and some immune inhibitors, such as PDCD1 and CTLA4, which have been reported to enhance the immune responses, were striking ( Fan et al, 2021b ; Lu et al, 2022 ). Immune checkpoint expression also differed between the SRR-high and SRR-low expression groups.…”

Section: Discussionmentioning

confidence: 96%

“…We discovered that the IC50 of doxorubicin, docetaxel, and paclitaxel was higher in the SRR-low expression group than in the SRR-high expression group, implying that patients with SRR-high expression were more sensitive to these drugs. Because chemotherapy drugs can have serious adverse effects, it is vital to screen people who are sensitive to them so that adverse reactions are minimized ( Fan et al, 2021b ; Lu et al, 2022 ). SRR expression could also be used as a biomarker to screen patients with UCEC for chemotherapy, according to our findings.…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

Cui

Wang

et al. 2022

Front. Genet.

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Endometrial cancer (EC) kills about 76,000 women worldwide, with the highest incidence in industrialized countries. Because of the rise in disease mortality and new diagnoses, EC is now a top priority for women’s health. Serine racemase (SRR) is thought to play a role in the central nervous system, but its role in cancers, particularly in EC, is largely unknown. The current study starts with a pan-cancer examination of SRR’s expression and prognostic value before delving into SRR’s potential cancer-suppressing effect in patients with EC. SRR may affect the endometrial tumor immune microenvironment, according to subsequent immune-related analysis. SRR expression is also linked to several genes involved in specific pathways such as ferroptosis, N6-methyladenosine methylation, and DNA damage repair. Finally, we used the expression, correlation, and survival analyses to investigate the upstream potential regulatory non-coding RNAs of SRR. Overall, our findings highlight the prognostic significance of SRR in patients with EC, and we can formulate a reasonable hypothesis that SRR influences metabolism and obstructs key carcinogenic processes in EC.

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“…In the present study, SRR was found to have positive correlations with TMB and MSI in UCEC. Furthermore, the correlations between SRR and some immune inhibitors, such as PDCD1 and CTLA4, which have been reported to enhance the immune responses, were striking (Fan et al, 2021b;Lu et al, 2022). Immune checkpoint expression also differed between the SRRhigh and SRR-low expression groups.…”

Section: Discussionmentioning

confidence: 92%

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CSMD1 Mutation Related to Immunity Can Be Used as a Marker to Evaluate the Clinical Therapeutic Effect and Prognosis of Patients with Esophageal Cancer

Cited by 12 publications

References 61 publications

Identification of immune-related ferroptosis prognostic marker and in-depth bioinformatics exploration of multi-omics mechanisms in thyroid cancer

Identification of immune-related ferroptosis prognostic marker and in-depth bioinformatics exploration of multi-omics mechanisms in thyroid cancer

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

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