CT and microbiologic follow-up in primary multidrug-resistant pulmonary tuberculosis

Kim, Wooil; Lee, Kyung Soo; Kim, Hyun Su; Koh, Won‐Jung; Jeong, Byeong‐Ho; Chung, Myung Jin; Jang, Hye Won

doi:10.1177/0284185115575196

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…The frequency and extent of these CT findings did not differ significantly between these two groups in our study, consistent with previous reports[4, 6, 8, 12, 14, 17]. Centrilobular micronodules and tree-in-bud appearance are the most common CT findings of active pulmonary tuberculosis[18].…”

Section: Discussionsupporting

confidence: 92%

“…The imaging features associated with chronicity or the TB healing process may not be common in patients with primary MDR TB[7]. In primary MDR-TB, the two most frequent abnormal CT patterns are tree-in-bud sign and acinar nodule[8]. The potential of radiologic evidence to indicate MDR—TB merits investigation because of the rapid availability of CT.…”

Section: Introductionmentioning

confidence: 99%

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Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Chen

et al. 2017

PLoS ONE

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BackgroundMultidrug-resistant tuberculosis has emerged as a global threat. The aim of this work was to compare the CT findings of primary multidrug-resistant tuberculosis and drug-sensitive tuberculosis in non-AIDS adults.Material and methodsFrom January 2012 to February 2016, 89 patients with primary multidrug-resistant tuberculosis were retrospectively reviewed, and 89 consecutive drug sensitive TB patients with no history of anti-tuberculous chemotherapy from January 2014 to November 2014 were enrolled as control group. All patients were seronegative for HIV. The patients’ demographic data and the locations, frequency and patterns of lung lesions on chest CT were compared.ResultsGender and frequency of diabetes were similar between the two groups. The mean age of primary multidrug-resistant tuberculosis patients was younger than that of drug-sensitive tuberculosis (39.0 vs 47.5, P = 0.005). Lung cavitary nodules or masses were more frequently observed and also showed greater extent in primary multidrug-resistant tuberculosis compared with drug-sensitive tuberculosis. The extent of bronchiectasis was significantly greater in primary multidrug-resistant tuberculosis than in drug-sensitive tuberculosis. Calcification, large nodules and calcified lymph nodes were more frequent in drug-sensitive tuberculosis.ConclusionCharacteristic chest CT findings may help differentiate between primary multi-drug resistant tuberculosis and drug-sensitive tuberculosis in patients without HIV infection.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Chen

et al. 2017

PLoS ONE

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“…With the criteria defined in the method section, 17 articles were included for analysis (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). The commonly reported imaging findings of pulmonary MDR-TB included centrilobular small nodules, branching linear and nodular opacities (tree-in-bud sign), patchy or lobular areas of consolidation, cavitation, and bronchiectasis (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). The centrilobular small nodules and tree-in-bud sign reflect the presence of endobronchial spread and are due to the presence of caseous necrosis and granulomatous inflammation filling surrounding terminal and respiratory bronchioles and alveolar ducts.…”

Section: General Findings and Limitation Of The Reported Studiesmentioning

confidence: 99%

Radiological signs associated with pulmonary multi-drug resistant tuberculosis: an analysis of published evidences

Wáng

Chung

Skrahin

et al. 2018

Quant. Imaging Med. Surg.

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“…Dalam penelitian ini, proporsi lakilaki lebih banyak, hal ini dikaitkan dengan salah satu faktor risiko yang paling umum yaitu merokok, di mana semua pasien yang memiliki kebiasaan merokok dalam penelitian ini adalah laki-laki. 5 Rentang usia pasien adalah 15-75 tahun, dengan usia rata-rata 45,62 tahun, dan distribusi tertinggi dalam kelompok usia 46-55 tahun. WHO pada tahun 2013 menyatakan bahwa sebagian besar pasien TB berusia produktif.…”

Section: Pembahasanunclassified

“…7 Faktor risiko yang paling umum dievaluasi adalah merokok, ditemukan pada 25% pasien. 5,6 Pada sebagian besar pasien dalam penelitian ini, konsolidasi dikelilingi oleh beberapa opasitas nodular kecil. Hal ini konsisten dengan teori sebelumnya, di mana lesi kecil di sekitar konsolidasi adalah ciri khas TB paru yang membedakannya dari pneumonia karena penyebab lain.…”

Section: Pembahasanunclassified

Gambaran Radiografi Tuberkulosis Paru Multidrug-Resistant: Studi Retrospektif di Rumah Sakit Umum Dr. Soetomo Surabaya

Sulaiman

Handayani

Suwandi³

et al. 2020

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Background: Multidrug-resistant pulmonary tuberculosis (MDR-TB) is a major health problem worldwide. Prompt diagnosis is necessary for insuring appropriate therapy to lower morbidity and mortality, as well as to prevent disease transmission. Determination of drug-resistance patterns through microbiological examination is sometimes challenging, especially when the sputum acid-fast bacilli smear is negative. Therefore, it is worthwhile to investigate whether there may be radiographic patterns suggesting MDR-TB infection. The objective of this study was to evaluate the radiographic features of MDR-TB. Methods: From September 2015 to March 2018, 167 patients with microbiologically proven MDR-TB were enrolled in the study. All radiographs were obtained before the patients received MDR-TB chemotherapy regimen. Posterior-anterior chest radiography was performed using digital radiography system (Hitachi Radnext50 500mAs) and retrospectively reviewed as digital raw data. Results: Based on severity category, 60% had severe lesion, 31% had moderate lesion, and only 9% had mild lesion. The most frequently observed findings were ground glass opacity or consolidation, noted in 96% patients, with bilateral lung involvement in 81% patients; fibrosis (95%), cavity (78%; 87% of which were multiple), interstitial opacities (53%), pleural thickening and mediastinal shift (59%). Other radiological findings were calcification (16%), emphysema (13%), lung destruction (12%), atelectasis (10%), nodule (8%), bullae (8%), bronchiectasis (5%), miliary pattern (1%), pleural effusion (25%), pneumothorax (1%), and hilar lymphadenopathy (14%) which predominantly unilateral. Conclusion: The presence of severe pulmonary lesion, ground glass opacity or consolidation with bilateral lung involvement, fibrosis, multiple cavities, interstitial opacities, pleural thickening, and mediastinal shift are the main features of MDR-TB.

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CT and microbiologic follow-up in primary multidrug-resistant pulmonary tuberculosis

Abstract: In pMDR-TB, two most frequent abnormal CT patterns are tree-in-bud sign and acinar nodule. In 98% of patients, negative sputum conversion is achieved, and CT score also shows decrease in extent after TB chemotherapy.

Cited by 12 publications

References 15 publications

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Radiological signs associated with pulmonary multi-drug resistant tuberculosis: an analysis of published evidences

Gambaran Radiografi Tuberkulosis Paru Multidrug-Resistant: Studi Retrospektif di Rumah Sakit Umum Dr. Soetomo Surabaya

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