CT-Guidance Interstitial 125iodine Seed Brachytherapy as a Salvage Therapy for Recurrent Spinal Primary Tumors

Cao, Qian Q.; Wang, Jie J.; Wang, Hao; Meng, Na; Jiang, Ping; Jiang, Liang; Tian, Qing; Liu, Chen

doi:10.1016/j.brachy.2015.02.264

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…According to the literature and clinical experiences gained at our center, 110 to 180 Gy is the dose range that elicits a good therapeutic effect. 2,4,8 –14 The dose prescribed in our study was set at 110 to 160 Gy.…”

Section: Methodsmentioning

confidence: 99%

Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Jiang

Liang

et al. 2017

Technol Cancer Res Treat

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Objective:To compare dose distributions of postoperative plans with preoperative plans for radioactive seed implantation of paravertebral/retroperitoneal tumors assisted by 3-dimensional printing noncoplanar templates and computed tomography.Methods:Sixteen patients with paravertebral/retroperitoneal tumors (21 lesions) underwent radioactive seed implantation with 3-dimensional printing noncoplanar templates. Prescribed dose was 110 to 160 Gy. We compared the dose distribution of the postoperative plan with the preoperative plan. Dose parameters were D90, minimum peripheral dose, V100, V150, conformal index and external index of the target volume, and the dose received by 2 cm3 of normal tissue of organs at risk (spinal cord, aorta, and kidney).Results:Sixteen 3-dimensional printing noncoplanar templates were produced for 21 treatment areas. Mean gross tumor volume (preoperative) of patients was 61.1 cm3, mean needle number was 17, mean number of implanted 125I seeds was 65, and mean D90 of postoperative target area (gross tumor volume) was 131.1 Gy. Actual number of seeds postbrachytherapy increased by 1 to 12 in 8 cases. For postoperative plans, the mean D90, minimum peripheral dose, V100, V150 was 131.1 Gy, 67.1 Gy, 90.2%, and 64.1%, respectively, and 135.0 Gy, 64.7 Gy, 90.9%, and 64.1%, respectively, in preoperative plans. Comparing with the preplanned cases, the dose of the target volume was slightly lower and the high-dose area of the target volume was larger in postoperative cases, but the difference was not statistically significant (P > .05). Actual dose conformity of the target volume was lower than preplanned, and the difference was statistically significant (P = .005).Conclusion:Three-dimensional printing noncoplanar templates can provide good accuracy for positioning and direction in radioactive seed implantation.

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Section: Methodsmentioning

confidence: 99%

Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Jiang

Liang

et al. 2017

Technol Cancer Res Treat

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“…With the development of minimally invasive therapy, radioactive seed implantation in the treatment of tumors has attracted more and more attention, and the scope of clinical applications has also been expanding. 125 I seed implantation has been widely used in the treatment of various malignant tumors, which has de nite clinical e cacy [13][14][15][16][17][18][19][20][21] . To our knowledge, there are few reports on CT-guided 125 I seed implantation by coplanar templatein the treatment for vertebral metastases.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

Man

Bai

et al. 2023

Preprint

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Purpose To evaluate the efficacy and safety of computed tomography (CT)-guided 125I seed implantation by coplanar template for vertebral metastases after failure of external beam radiation therapy. We also want to compare the dosimetry of 3D printed coplanar template-assisted interstitial 125I brachytherapy preoperative and postoperative, and to explore the accuracy of this technology. Material and methods We retrospectively collected and analyzedthe results of 56 patients with vertebral metastases after failure of external beam radiation therapy, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2015 to January 2017. Results The NRS score for worst pain was 6.1 ± 1.1 before 125I seed implantation. The mean posto-perative NRS score decreased significantly at T4w (3.5 ± 0.9, p < 0.01), T8w (2.1 ± 0.9, p < 0.01), T12w (1.5 ± 0.7, p < 0.01) and T6m (1.2 ± 0.6, p < 0.01) respectively. There was no significant difference in scores among T0, T24h (P = 0.10) and T1w (P = 0.09). The local control rates after 3, 6, 9 and 12 months were 100% (58/58), 92.5% (49/53), 90.2% (46/51), and 85.1% (40/47), respectively. By performing paired t-test analysis, there were no significant differences in D90, D100, V90, V100, V150, V200, GTV volume, CI, EI and HI between preoperative and postoperative(p༞0.05). Postoperative D90 was an independent influencing factor of local control time (HR: 1.047, 95% CI: 0.998–1.098, p = 0.043). The optimal Cut-off value of postoperative D90 was 130 Gy. Conclusions Interstitial 125I seed implantation can be used as a salvage treatment forpatients with vertebral metastases after failure of external beam radiation therapy. With the auxiliary function of 3D printed coplanar template, the main dosimetry parameters verified after the operation can meet the requirements of the preoperative plan with good treatment accuracy.

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“…125 I seed implantation has been widely used in the treatment of head and neck tumor, lung cancer, locally advanced pancreatic tumor, recurrent rectal tumor, prostate tumor, and malignant luminal obstruction. 17 – 25 It has been reported that 125 I seeds can be used to treat cervical lymph node metastasis after radiotherapy of esophageal squamous cell cancer. 26 , 27 In the past, interstitial 125 I brachytherapy was completed by freehand, which seriously depended on the experience of the performer.…”

Section: Introductionmentioning

confidence: 99%

Interstitial ¹²⁵I Brachytherapy as a Salvage Treatment for Refractory Cervical Lymph Node Metastasis of Thoracic Esophageal Squamous Cell Carcinoma After External Irradiation With a CT-Guided Coplanar Template-Assisted Technique: A Retrospective Study

Fan

Zhang

et al. 2022

Technol Cancer Res Treat

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Purpose: To analyze the outcome and prognosis of patients with refractory cervical lymph node metastasis of thoracic esophageal squamous cell carcinoma after external irradiation, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique. We also want to compare the dosimetry of 3D printed coplanar template-assisted interstitial 125I brachytherapy preoperative and postoperative, and to explore the accuracy of this technology. Material and methods: We retrospectively collected and analyzed the results of 32 patients with refractory cervical lymph node metastasis of thoracic esophageal squamous cell carcinoma after external irradiation, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2012 to December 2017. Results: The actual D90 were 114 to 240 Gy, and the median postoperative dosimetry assessment was 177.5 Gy. The local control rates at 3, 6, 9, and 12 months were 87.5%, 59.38%, 40.63%, and 31.25%, respectively. The median local control time was 7.5 months. The median overall survival time was 10.5 months (95% CI, 8.9-13.4), and the survival rates of 1- and 2-year, respectively, were 43.75% and 9.38%. There were 36 lesions in 32 patients. By performing a paired t-test analysis, there was no significant difference in D90, D100, V100, V150, V200, GTV volume, CI, EI, and HI between preoperative and postoperative ( P > .05). Conclusions: Interstitial 125I brachytherapy can be used as a salvage treatment for patients with refractory cervical lymph node metastasis of thoracic esophageal squamous cell carcinoma after external irradiation. With the auxiliary function of 3D printed coplanar template, the main dosimetry parameters verified after the operation can meet the requirements of the preoperative plan with good treatment accuracy.

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CT-Guidance Interstitial 125iodine Seed Brachytherapy as a Salvage Therapy for Recurrent Spinal Primary Tumors

Cited by 5 publications

References 16 publications

Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

Interstitial ¹²⁵I Brachytherapy as a Salvage Treatment for Refractory Cervical Lymph Node Metastasis of Thoracic Esophageal Squamous Cell Carcinoma After External Irradiation With a CT-Guided Coplanar Template-Assisted Technique: A Retrospective Study

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CT-Guidance Interstitial 125iodine Seed Brachytherapy as a Salvage Therapy for Recurrent Spinal Primary Tumors

Cited by 5 publications

References 16 publications

Dosimetry Verification of 125I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Dosimetry Verification of 125I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

Interstitial 125I Brachytherapy as a Salvage Treatment for Refractory Cervical Lymph Node Metastasis of Thoracic Esophageal Squamous Cell Carcinoma After External Irradiation With a CT-Guided Coplanar Template-Assisted Technique: A Retrospective Study

Contact Info

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Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Dosimetry Verification of ¹²⁵I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors

Interstitial ¹²⁵I Brachytherapy as a Salvage Treatment for Refractory Cervical Lymph Node Metastasis of Thoracic Esophageal Squamous Cell Carcinoma After External Irradiation With a CT-Guided Coplanar Template-Assisted Technique: A Retrospective Study