CT perfusion in solid-body tumours. Part I: technical issues

Petralia, Giuseppe; Preda, Lorenzo; D’Andrea, Gabriele; Viotti, Stefano; Bonello, Luke; Filippi, Roberto; Bellomi, Massimo

doi:10.1007/s11547-010-0519-y

Cited by 42 publications

(26 citation statements)

References 32 publications

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“…For this purpose, the total organ (tumor) volume is scanned at different points in time. The density in two different ROIs, in an afferent artery and the desired tissue, is compared in the subsequent mathematical analysis [13]. Different mathematical kinetic models are used.…”

Section: Volume Perfusion Ct (Vpct)mentioning

confidence: 99%

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

Grözinger¹,

Grözinger²,

Horger³

2014

Fortschr Röntgenstr

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The review discusses the potential role of volume perfusion CT (VPCT) in the diagnosis and follow-up of different pathologies of the pancreas. VPCT enables a differentiation of different pancreatic tumors like adenocarcinoma or neuroendocrine tumors based on functional parameters like blood flow, blood volume and permeability. Furthermore, the article discusses the potential indications for VPCT imaging of inflammatory diseases of the pancreas such as acute or chronic pancreatitis and autoimmune pancreatitis. Key Points: ??VPCT may help to diagnose even small pancreatic tumors based on functional parameters ??Functional perfusion parameters can help to characterize pancreatic neoplasms ??In acute pancreatitis VPCT can evaluate the perfusion status of the organ Citation Format: ??Gr?zinger G., Gr?zinger A., Horger M. The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas. Fortschr R?ntgenstr 2014; 186: 1082???1093

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Section: Volume Perfusion Ct (Vpct)mentioning

confidence: 99%

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

Grözinger¹,

Grözinger²,

Horger³

2014

Fortschr Röntgenstr

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“…Neoplastic angiogenesis has been regarded as a useful and promising target for new treatments (54). In recent years, CT perfusion has been developed as a noninvasive imaging modality that can provide both qualitative and quantitative information regarding the angiogenic characteristics of tumors (Fig.…”

Section: Ct Response Assessment After Molecular Targeted Therapymentioning

confidence: 99%

“…4). Technical details about CT perfusion are extensively discussed in a review by Petralia et al (54). CT perfusion shows encouraging results for prognosis and therapy assessment in advanced NSCLC treated with chemotherapy.…”

Section: Ct Response Assessment After Molecular Targeted Therapymentioning

confidence: 99%

Non-small cell lung cancer after surgery and chemoradiotherapy: follow-up and response assessment

Colombi¹,

Lauro²,

Silva³

et al. 2013

Diagn Interv Radiol

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The imaging techniques in patients treated for lung cancer may be challenging to interpret. Radiologists are often asked to evaluate computed tomography (CT) scans after surgery, and this interpretation requires an understanding of both the timing and type of the surgical procedure. However, follow-up strategies are still not well defined. The assessment of tumor response to chemoradiotherapy relies on a tight integration of CT and clinical findings. Positron emission tomography-computed tomography (PET-CT) with fluorodeoxyglucose may help to exclude tumor recurrence when the sole CT scan is equivocal. More efforts are needed to validate the tools for volumetric tumor measurement in routine practice and to demonstrate their superiority compared to the Response Evaluation Criteria in Solid Tumors (RECIST). Familiarity with the assessment of lung cancer perfusion is also important because of the increasing use of cytostatic therapy. In this review, we outlined the imaging assessment of tumor recurrence after surgery and the role of CT, magnetic resonance imaging, and PET-CT in the follow-up after chemotherapy, radiotherapy, and radiofrequency ablation.

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“…where E is the fraction of contrast that leaks into the interstitium from the vascular space (EF) (Petralia, Preda et al 2010).…”

Section: Ct Perfusionmentioning

confidence: 99%