CTPS1 inhibition synergizes with replication stress signaling inhibition inMYC-amplified Group 3 medulloblastoma
Matthew R Hathaway,
Katherine E Gadek,
Hawa L Jagana
et al.
Abstract:MYC-driven medulloblastomas (MBs) represent the most aggressive and deadly subgroup of MB, the most common malignant pediatric brain tumor. Direct targeting of MYC itself remains an unmet clinical need, therefore focusing on vulnerabilities driven by MYC may be a viable option for novel therapeutic interventions. Using whole-genome CRISPR screening, we identified thede novopyrimidine synthesis enzyme CTP synthase (CTPS1) as a strong dependency inMYC-driven MB. CTPS1 is the final and rate-limiting step in thede… Show more
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