CtsR Is the Master Regulator of Stress Response Gene Expression in<i>Oenococcus oeni</i>

Grandvalet, Cosette; Coucheney, Françoise; Beltramo, Charlotte; Guzzo, Jean

doi:10.1128/jb.187.16.5614-5623.2005

Cited by 66 publications

(65 citation statements)

References 64 publications

(51 reference statements)

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“…Conversely, the expression of the other four genes was considerably repressed (approximately 10-fold lower). These results strongly suggest a negative regulation exerted by CtsR on its own operon, as well as on hsp1 and clp genes, in agreement with previously characterized CtsR regulons (2,4,8,15,24,35). On the other hand, since the transcription of nrpR1, lp_1995, lp_2090, and lp_2942 appears affected by CtsR inactivation, we cannot rule out that the expression of these genes might be controlled by CtsR activity either directly or indirectly.…”

supporting

confidence: 71%

“…However, in staphylococci, the CtsR regulon also comprises the groESL and dnaK operons (3) and, in Oenococcus oeni, even a small-HSP gene (15). Recently, we have reported that the Lactobacillus plantarum ftsH gene, encoding a membrane-bound metalloprotease, is a novel member of the CtsR stress response regulon, representing an exception with respect to other Gram-positive species (11).…”

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confidence: 99%

“…A small heat shock gene named Lo18 was also reported to be controlled by CtsR in O. oeni (15); therefore, L. plantarum hsp1 would represent an additional example of ctsR-mediated regulation of small HSPs.…”

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confidence: 99%

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Characterization of the CtsR Stress Response Regulon in Lactobacillus plantarum

et al. 2010

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Lactobacillus plantarum ctsR was characterized. ctsR was found to be cotranscribed with clpC and induced in response to various abiotic stresses. ctsR deletion conferred a heat-sensitive phenotype with peculiar cell morphological features. The transcriptional pattern of putative CtsR regulon genes was examined in the ⌬ctsR mutant. Direct CtsR-dependent regulation was demonstrated by DNA-binding assays using recombinant CtsR and the promoters of the ctsR-clpC operon and hsp1.

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Characterization of the CtsR Stress Response Regulon in Lactobacillus plantarum

et al. 2010

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“…O. oeni was the first example of a low-GC Gram-positive bacterial species that lacks the widely conserved CIRCE-HrcA regulatory circuit. Its CtsR regulon comprises genes that encode the classical chaperone proteins DnaK, GroEL, and GroES and Clp proteins (317). An example of reductive evolution of stress repressors with a different outcome is provided by Lb.…”

Section: Treating Damaged Macromoleculesmentioning

confidence: 99%

“…The expression of S. salivarius and S. thermophilus clpP is under dual regulation by CtsR and HrcA (316). The HrcA and CtsR regulons may partially overlap in several other members of the Streptococcaceae (316,317). Sequence analysis of Lb.…”

Section: Treating Damaged Macromoleculesmentioning

confidence: 99%

Stress Physiology of Lactic Acid Bacteria

Papadimitriou

Alegría

Bron

et al. 2016

Microbiol Mol Biol Rev

541

404

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SUMMARYLactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms. The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by the technological implications of LAB robustness in the food industry. Survival of probiotic LAB in the host and the potential relatedness of LAB virulence to their stress resilience have intensified interest in the field. Thus, a wealth of information concerning stress responses exists today for strains as diverse as starter (e.g.,Lactococcus lactis), probiotic (e.g., severalLactobacillusspp.), and pathogenic (e.g.,EnterococcusandStreptococcusspp.) LAB. Here we present the state of the art for LAB stress behavior. We describe the multitude of stresses that LAB are confronted with, and we present the experimental context used to study the stress responses of LAB, focusing on adaptation, habituation, and cross-protection as well as on self-induced multistress resistance in stationary phase, biofilms, and dormancy. We also consider stress responses at the population and single-cell levels. Subsequently, we concentrate on the stress defense mechanisms that have been reported to date, grouping them according to their direct participation in preserving cell energy, defending macromolecules, and protecting the cell envelope. Stress-induced responses of probiotic LAB and commensal/pathogenic LAB are highlighted separately due to the complexity of the peculiar multistress conditions to which these bacteria are subjected in their hosts. Induction of prophages under environmental stresses is then discussed. Finally, we present systems-based strategies to characterize the “stressome” of LAB and to engineer new food-related and probiotic LAB with improved stress tolerance.

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The genus Oenococcus

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Lactic Acid Bacteria

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CtsR Is the Master Regulator of Stress Response Gene Expression inOenococcus oeni

Cited by 66 publications

References 64 publications

Characterization of the CtsR Stress Response Regulon in Lactobacillus plantarum

Characterization of the CtsR Stress Response Regulon in Lactobacillus plantarum

Stress Physiology of Lactic Acid Bacteria

The genus Oenococcus

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