Cu@CuFe₂O₄ nanoparticles catalyzed oxidative functionalization of alkynes: Access to α,α‐dichloro ketones

Abstract

In this study, novel Cu@CuFe2O4 nanoparticles were prepared by virtue of a simple method. By utilizing a compatible system involving N‐chlorosuccinimide (NCS) as the chlorine source and Cu@CuFe2O4 magnetic nanoparticles (NPs) as recyclable catalyst, we present a novel and practical method for directly obtaining aryl α,α‐dichloroketones in aqueous trifluoroethanol (TFE). The catalyst was recovered and reused up to five times with no significant decrease in activity. The current study provides a foundational raw material for the subsequent synthesis of chlorinated functional molecules, which is achieved through a mild transformation of arylalkynes using readily available commercial feedstocks and exhibiting good tolerance with various substituents on the aromatic ring, including the aliphatic alkyne. This novel heterogeneous catalyst may be used in numerous industrial applications because of its merits, such as considerable recyclability, low requirement for catalyst loading, cost‐effectiveness, and ease of handling.