Cu-Doped black phosphorus quantum dots as multifunctional Fenton nanocatalyst for boosting synergistically enhanced H₂O₂-guided and photothermal chemodynamic cancer therapy

Abstract

Chemodynamic therapy (CDT) is a cancer treatment that converts endogenous H2O2 into hydroxyl radicals (˙OH) through Fenton reaction to destroy cancer cells.

Highly Efficient GSH-Responsive “Off–On” NIR-II Fluorescent Fenton Nanocatalyst for Multimodal Imaging-Guided Photothermal/Chemodynamic Synergistic Cancer Therapy

“…10,11 CDT is an emerging tumor therapy strategy that utilizes tumor in situ hydrogen peroxide (H 2 O 2 ) as a raw material to generate hydroxyl radicals (•OH) to kill tumor cells under the catalysis of Fenton/Fenton-like catalysts (Mn 2+ , Cu + , Fe 2+ , etc.). 6,12,13 However, the high content of GSH (up to 10 mM) and the low content of H 2 O 2 (100 μM) in TME limit the efficiency of CDT. 4,9,14 Glucose oxidase (GOD) can catalyze glucose to produce abundant H 2 O 2 for Fenton-like reactions to enhance the CDT effect.…”

“…Interestingly, MnO 2 nanosheets are an appealing GSH-responsive material, and the released Mn 2+ can be not only for MRI but also as a catalyst for chemodynamic therapy (CDT). , CDT is an emerging tumor therapy strategy that utilizes tumor in situ hydrogen peroxide (H 2 O 2 ) as a raw material to generate hydroxyl radicals (·OH) to kill tumor cells under the catalysis of Fenton/Fenton-like catalysts (Mn 2+ , Cu + , Fe 2+ , etc. ). ,, However, the high content of GSH (up to 10 mM) and the low content of H 2 O 2 (100 μM) in TME limit the efficiency of CDT. ,, Glucose oxidase (GOD) can catalyze glucose to produce abundant H 2 O 2 for Fenton-like reactions to enhance the CDT effect. In addition, photothermal therapy (PTT) can accelerate the Fenton-like reaction and enhance CDT while ablating tumor cells by hyperthermia. , Moreover, the targeting ability of materials is crucial in tumor diagnosis and treatment. , It has been reported that cell membrane-coated nanoparticles can greatly improve the biosafety of nanocatalysts, enabling it to escape the immunity system and improve homologous targeting to parental cells through self-recognition and internalization by cancer cell lines. − …”

Advances in Delivering Oxidative Modulators for Disease Therapy

“…Among the liquid metals, an important class is eutectic gallium-indium alloys, which can produce ROS under microwave radiation. (4) Fenton catalysts (e.g., iron ions, copper sulfide, Cu I , and Mn 2+ ) can mediate the Fenton reaction to achieve redox reactions and promote the generation of ROS [38][39][40]. Iron ions are the most widely studied metal ions with Fenton activity and have recently been popularly researched.…”

Sorafenib-Loaded Copper Peroxide Nanoparticles with Redox Balance Disrupting Capacity for Enhanced Chemodynamic Therapy against Tumor Cells

“…21 As a Fenton-like reagent, copper has redox properties similar to those of iron. 22 Cu + can react with H 2 O 2 to form •OH and Cu 2+ , which can occur with considerable efficiency in slightly acidic and neutral media. 23−25 Currently, great efforts have been paid to increasing the H 2 O 2 content to improve the CDT efficacy.…”

“…Currently, iron-based nanomaterials are widely used as Fenton reagents for CDT. − However, the Fe 2+ -mediated Fenton reaction is only effective in strongly acidic media (pH = 2–4) . As a Fenton-like reagent, copper has redox properties similar to those of iron . Cu + can react with H 2 O 2 to form •OH and Cu 2+ , which can occur with considerable efficiency in slightly acidic and neutral media. − …”