Cu-doped calcium phosphate supraparticles for bone tissue regeneration

Höppel, Anika; Bahr, Olivia; Ebert, Regina; Wittmer, Annette; Seidenstuecker, Michael; Carolina Lanzino, M.; Gbureck, Uwe; Dembski, Sofia

doi:10.1039/d4ra04769a

RSC Adv.

2024

DOI: 10.1039/d4ra04769a

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Cu-doped calcium phosphate supraparticles for bone tissue regeneration

Anika Höppel,

Olivia Bahr,

Regina Ebert

et al.

Abstract: Antibacterial, biodegradable spray dried Cu-doped CaP supraparticles with high cell viability show great potential as bone substitute materials.

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Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties

Lanzino,

Le,

Höppel

et al. 2024

JFB

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Prosthesis loosening due to lack of osteointegration between an implant and surrounding bone tissue is one of the most common causes of implant failure. Further, bacterial contamination and biofilm formation onto implants represent a serious complication after surgery. The enhancement of osteointegration can be achieved by using bioconductive materials that promote biological responses in the body, stimulating bone growth and thus bonding to tissue. Through the incorporation of antibacterial substances in bioconductive, biodegradable calcium phosphate (CaP) coatings, faster osteointegration and bactericidal properties can be achieved. In this study, Cu-doped CaP supraparticles are spray-dried and suspension-sprayed CaP ceramic coatings with antibacterial properties are prepared using high-velocity suspension flame spraying (HVSFS). The objective was to increase the coatings’ porosity and investigate which Cu-doped supraparticles have the strongest antibacterial properties when introduced into the coating layers. Biocompatibility was tested on human Osteosarcoma cells MG63. A porosity of at least 13% was achieved and the supraparticles could be implemented, enhancing it up to 16%. The results showed that the addition of Cu-doped supraparticles did not significantly reduce the number of viable cells compared to the Cu-free sample, demonstrating good biocompatibility. The antimicrobial activity was assessed against the bacterial strains Escherichia coli and Staphylococcus aureus, with Safe Airborne Antibacterial testing showing a significant reduction in both Gram-positive and Gram-negative strains on the Cu-doped coatings.

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Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties

Lanzino,

Le,

Höppel

et al. 2024

JFB

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Cu-doped calcium phosphate supraparticles for bone tissue regeneration

Abstract: Antibacterial, biodegradable spray dried Cu-doped CaP supraparticles with high cell viability show great potential as bone substitute materials.

Cited by 1 publication

References 58 publications

Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties

Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties

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