Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Li, Zhen; Yan, Hui; Chang, Guoliang; Hong, Min; Dou, Jianmin; Niu, Meiju

doi:10.1016/j.jphotobiol.2016.09.005

Cited by 56 publications

(23 citation statements)

References 45 publications

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“…The amino acid residues closest to the ligand, including Glu-125, Lys-136 and Thr-121 etc. , suggest hydrophobic and van der Waals interactions to the compound, 82,83 consistent with the spectroscopic data.…”

Section: Resultssupporting

confidence: 86%

“… 71 The docking calculations were performed using AutoDock 4.2 ( , free software), which combines a rapid energy evaluation through pre-calculated grids of affinity potentials with a variety of search algorithms. 72 The crystal structure of BSA (PDB ID: ) was obtained from the RCSB Protein Data Bank ( ). All water molecules were removed, and then polar hydrogen atoms were added to the BSA molecule.…”

Section: Methodsmentioning

confidence: 99%

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Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

et al. 2018

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Section: Resultssupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

et al. 2018

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“…Several Ni complexes have been synthesized as anticancer agents and show promising anti-proliferative activities. These include, among others, N-heterocyclic carbene complexes, Ni pyrithione, Ni diacetyl monoxime-2-pyridyl hydrazine, Ni thiosemicarbazones, , Schiff base Ni chelates, , a Ni-dithiocarbamate phenanthroline complex, and Ni diacetyl monoxime-2-pyridyl hydrazine …”

Section: Immunological Effects Of Specific Metal Drugsmentioning

confidence: 99%

Metal Drugs and the Anticancer Immune Response

et al. 2018

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The immune system deploys a multitude of innate and adaptive mechanisms not only to ward off pathogens but also to prevent malignant transformation ("immune surveillance"). Hence, a clinically apparent tumor already reflects selection for those malignant cell clones capable of evading immune recognition ("immune evasion"). Metal drugs, besides their well-investigated cytotoxic anticancer effects, massively interact with the cancer-immune interface and can reverse important aspects of immune evasion. This topic has recently gained intense attention based on combination approaches with anticancer immunotherapy (e.g., immune checkpoint inhibitors), a strategy recently delivering first exciting results in clinical settings. This review summarizes the promising but still extremely fragmentary knowledge on the interplay of metal drugs with the fidelity of anticancer immune responses but also their role in adverse effects. It highlights that, at least in some cases, metal drugs can induce long-lasting anticancer immune responses. Important steps in this process comprise altered visibility and susceptibility of cancer cells toward innate and adaptive immunity, as well as direct impacts on immune cell populations and the tumor microenvironment. On the basis of the gathered information, we suggest initiating joint multidisciplinary programs to implement comprehensive immune analyses into strategies to develop novel and smart anticancer metal compounds.

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“…The in vitro cytotoxicity activity of the complexes were investigated for various human lung cervical cell line (Hela), human lung adenocarcinoma (A549) and human breast cancer cell line (MCF-7) by the MTT assay. The results showed that copper and nickel complexes exhibited good cytotoxic activity [46].…”

Section: Introductionmentioning

confidence: 99%

Schiff Base Metal Complexes as Anticancer Agents

Sridevi

Antony

R³

2019

Asian J. Chem.

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Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

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Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Cited by 56 publications

References 45 publications

Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

Metal Drugs and the Anticancer Immune Response

Schiff Base Metal Complexes as Anticancer Agents

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