Cu impedance-based detection of superparamagnetic nanoparticles

Lago-Cachón, D.; Rivas, M.; Martínez-García, J.C.; Garcı́a, J.A.

doi:10.1088/0957-4484/24/24/245501

Cited by 17 publications

(12 citation statements)

References 21 publications

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“…Recently, we have developed a quantitative magnetic LFIA for EVs detection [ 38 ]. For this approach, magnetic LFIAs have been coupled to a sensor developed by the authors to get the quantification for different concentration of isolated EVs from human plasma [ 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Lateral Flow Immunoassay for Small Extracellular Vesicles Quantification: Application to Colorectal Cancer Biomarker Detection

Moyano

Serrano-Pertierra

Duque

et al. 2021

Sensors

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Colorectal cancer (CRC) is the third leading cause of cancer death and the fourth most common cancer in the world. Colonoscopy is the most sensitive test used for detection of CRC; however, their procedure is invasive and expensive for population mass screening. Currently, the fecal occult blood test has been widely used as a screening tool for CRC but displays low specificity. The lack of rapid and simple methods for mass screening makes the early diagnosis and therapy monitoring difficult. Extracellular vesicles (EVs) have emerged as a novel source of biomarkers due to their contents in proteins and miRNAs. Their detection would not require invasive techniques and could be considered as a liquid biopsy. Specifically, it has been demonstrated that the amount of CD147 expressed in circulating EVs is significant higher for CRC cell lines than for normal colon fibroblast cell lines. Moreover, CD147-containing EVs have been used as a biomarker to monitor response to therapy in patients with CRC. Therefore, this antigen could be used as a non-invasive biomarker for the detection and monitoring of CRC in combination with a Point-of-Care platform as, for example, Lateral Flow Immunoassays (LFIAs). Here, we propose the development of a quantitative lateral flow immunoassay test based on the use of magnetic nanoparticles as labels coupled to inductive sensor for the non-invasive detection of CRC by CD147-positive EVs. The results obtained for quantification of CD147 antigen embedded in EVs isolated from plasma sample have demonstrated that this device could be used as a Point-of-Care tool for CRC screening or therapy monitoring thanks to its rapid response and easy operation.

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Section: Introductionmentioning

confidence: 99%

Magnetic Lateral Flow Immunoassay for Small Extracellular Vesicles Quantification: Application to Colorectal Cancer Biomarker Detection

Moyano

Serrano-Pertierra

Duque

et al. 2021

Sensors

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“…If extrapolated, the best sensor material for detecting NMPs should be one with no MI effect at all. This is not completely surprising, as there is experimental evidence of a larger response from a plain Cu sensor than from an MI amorphous ribbon in a measurement performed in the same conditions [27]. In fact, this behavior could have been anticipated: if the change in the impedance of the sensor in the presence of MNPs is a consequence of changes in the distribution of the electromagnetic field due to the permeability of the particles, then this effect should be larger when the permeability of the sensor itself is smaller than that of the system of MNPs.…”

Section: Resultsmentioning

confidence: 78%

The Performance of the Magneto-Impedance Effect for the Detection of Superparamagnetic Particles

Garcı́a-Arribas

2020

Sensors

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The performance of magneto-impedance sensors to detect the presence and concentration of magnetic nanoparticles is investigated, using finite element calculations to directly solve Maxwell’s equations. In the case of superparamagnetic particles that are not sufficiently magnetized by an external field, it is assumed that the sensitivity of the magneto-impedance sensor to the presence of magnetic nanoparticles comes from the influence of their magnetic permeability on the sensor impedance, and not from the stray magnetic field that the particles produce. The results obtained not only justify this hypothesis, but also provide an explanation for the discrepancies found in the literature about the response of magneto-impedance sensors to the presence of magnetic nanoparticles, where some authors report an increasing magneto-impedance signal when the concentration of magnetic nanoparticles is increased, while others report a decreasing tendency. Additionally, it is demonstrated that sensors with lower magneto-impedance response display larger sensitivities to the presence of magnetic nanoparticles, indicating that the use of plain, nonmagnetic conductors as sensing materials can be beneficial, at least in the case of superparamagnetic particles insufficiently magnetized in an external magnetic field.

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“…The field used to bias the sensing element (H B in Figure 1) is not enough for that end. In fact, the electrical impedance of nonmagnetic conductors also varies in the presence of magnetic particles and this effect has been proposed as an alternative method for biosensing [75]. More sensitivity is expected if the fringe field of the particles is measured directly using the MI effect as a magnetic field detector.…”

Section: Brief Survey Of Applicationsmentioning

confidence: 99%

Thin-Film Magneto-Impedance Sensors

Garcı́a-Arribas¹,

Férnández²,

Cos³

2017

Magnetic Sensors - Development Trends and Applications

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We review the state-of-the-art of thin films displaying the magneto-impedance (MI) effect, with focus on the aspects that are relevant to the successful design and operation of thin film-based magnetic sensors. After a brief introduction of the MI effect, the materials and geometries that maximize the performance, together with the measurement procedure for their characterization, are exposed. A nonexhaustive survey of applications is included, mostly with the aim of displaying the capabilities of thin film structures in the field of magnetic sensing, and the variety of topics covered by them. A special emphasis is made on some concepts that are not commonly treated in the literature, such as the influence of the measuring circuit on the magneto-impedance ratio, the geometry optimization by means of numerical simulation by finite element methods, or noise measurements on thin films. Additionally, a brief description of the patterning procedure by photolithography is included, since the major advantage of thin film sensors over other types of magneto-impedance materials as ribbons or wires is the possibility of patterning the sensible element in micrometric shapes, and most of all, their easy integration with the interface microelectronic circuitry.

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Cu impedance-based detection of superparamagnetic nanoparticles

Cited by 17 publications

References 21 publications

Magnetic Lateral Flow Immunoassay for Small Extracellular Vesicles Quantification: Application to Colorectal Cancer Biomarker Detection

Magnetic Lateral Flow Immunoassay for Small Extracellular Vesicles Quantification: Application to Colorectal Cancer Biomarker Detection

The Performance of the Magneto-Impedance Effect for the Detection of Superparamagnetic Particles

Thin-Film Magneto-Impedance Sensors

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