Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

Tian, Hailong; Zhang, Mengzhu; Jin, Guoxia; Jiang, Yue; Luan, Yuxia

doi:10.1016/j.jcis.2020.12.028

Cited by 218 publications

(133 citation statements)

References 42 publications

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“…[23][24][25][26] Up to now, a variety of carriers have been investigated for the co-delivery of drugs and genes/photosensitizers in anti-cancer trails, including cationic polymers, liposomes, human serum albumin, hydrogels and inorganic nanoparticles. [27][28][29][30][31][32][33] Among them, polymeric micelles formed by amphiphilic block copolymers have gained more attention due to their unique properties such as the core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs. [34][35][36][37] Polyethylene glycol-polylactic acid (PEG-PLA), one of the most prominent amphiphilic block copolymers, can self-assemble into micelles with core/shell structure in aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

Liang¹,

Wang²,

Shi³

et al. 2021

IJN

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Background: Multidrug resistance (MDR) has emerged to be a major hindrance in cancer therapy, which contributes to the reduced sensitivity of cancer cells toward chemotherapeutic drugs mainly owing to the over-expression of drug efflux transporters. The combination of gene therapy and chemotherapy has been considered as a potential approach to improve the anti-cancer efficacy by reversing the MDR effect. Materials and Methods: The AS1411 aptamer-functionalized micelles were constructed through an emulsion/solvent evaporation strategy for the simultaneous co-delivery of doxorubicin and miR-519c. The therapeutic efficacy and related mechanism of micelles were explored based on the in vitro and in vivo active targeting ability and the suppression of MDR, using hepatocellular carcinoma cell line HepG2 as a model. Results:The micelle was demonstrated to possess favorable cellular uptake and tumor penetration ability by specifically recognizing the nucleolin in an AS1411 aptamerdependent manner. Further, the intracellular accumulation of doxorubicin was significantly improved due to the suppression of ABCG2-mediated drug efflux by miR-519c, resulting in the efficient inhibition of tumor growth. Conclusion:The micelle-mediated co-delivery of doxorubicin and miR-519c provided a promising strategy to obtain ideal anti-cancer efficacy through the active targeting function and the reversion of MDR.

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Section: Introductionmentioning

confidence: 99%

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

Liang¹,

Wang²,

Shi³

et al. 2021

IJN

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“…Chemodynamic therapy (CDT) is a therapeutic method that can induce ROS in tumor cells and break the balance of intracellular redox/oxidation state [ 69 , 70 , 71 ]. However, the progress of CDT excessively depends on the reaction conditions, such as the content of H 2 O 2 , which is limited in TME [ 72 , 73 ]. This fact has been recognized as one of crucial obstacles for ensuring the anticancer efficacy of current CDT.…”

Section: Activated Cascade Reactions To Enhance Ros-induced Cancer Therapymentioning

confidence: 99%

Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

Sun

2021

IJMS

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In the current cancer treatment, various combination therapies have been widely used, such as photodynamic therapy (PDT) combined with chemokinetic therapy (CDT). However, due to the complexity of the tumor microenvironment (TME) and the limitations of treatment, the efficacy of current treatment options for some cancers is unsatisfactory. Nowadays, cascade technology has been used in cancer treatment and achieved good therapeutic effect. Cascade technology based on nanotechnology can trigger cascade reactions under specific tumor conditions to achieve precise positioning and controlled release, or amplify the efficacy of each drug to improve anticancer efficacy and reduce side effects. Compared with the traditional treatment, the application of cascade technology has achieved the controllability, specificity, and effectiveness of cancer treatment. This paper reviews the application of cascade technology in drug delivery, targeting, and release via nano-drug delivery systems in recent years, and introduces their application in reactive oxygen species (ROS)-induced cancer treatment. Finally, we briefly describe the current challenges and prospects of cascade technology in cancer treatment in the future.

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“…The advanced development of nanotechnologies provides powerful conditions for tumor treatment (Wicki et al., 2015 ; Li et al., 2017 ; Ren et al., 2021 ; Tian et al., 2021 ; Zhang et al., 2021 ), and they are demonstrated to prolong half-life (Cheng, & Liu, 2016 ; Nakamura et al., 2016 ; Wang et al., 2017 ) and improve accumulation in tumor sites by enhanced permeability and retention (EPR) effect (Li et al., 2013 ; Wang et al., 2017 ). Based on formation, the drugs can be delivered by nanoparticles via physical encapsulation or chemical conjugate (Zhu et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro

Lang

Li³

et al. 2021

Drug Delivery

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Chemotherapy plays a major role in the treatment of cancer, but it still has great limitations in anti-tumor effect. Carboplatin (CAR) is the first-line drug in the treatment of non-small cell lung cancer, but the therapeutic effect is demonstrated weak. Therefore, we modified CAR with hexadecyl chain and polyethylene glycol, so as to realize its liposolubility and PEGylation. The synthesized amphiphilic CAR prodrugs could self-assemble into polymer micelles in water with an average particle size about 11.8 nm and low critical micelles concentration (0.0538 mg·mL –1 ). In vivo pharmacodynamics and cytotoxicity experiment evidenced that the polymer micelles were equipped with preferable anti-tumor effect, finally attained the aim of elevating anti-tumor effect and prolonging retention time in vivo . The self-assembled micelles skillfully solve the shortcomings of weak efficacy of CAR, which provides a powerful platform for the application of chemical drug in oncology.

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Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

Cited by 218 publications

References 42 publications

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro

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