Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependent<i>in vitro</i>modulation of murine dendritic cells

Schuhladen, Katharina; Stich, Lena; Schmidt, Jochen; Steinkasserer, Alexander; Boccaccını, Aldo R.; Zinser, Elisabeth

doi:10.1039/c9bm01691k

Cited by 71 publications

(54 citation statements)

References 63 publications

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“…It allows bone tissue formation on the surface, bonding to surrounding living tissue when implanted in the body [9]. All BGs are functionally active due to two underlying mechanisms [10]: (i) promoting cellular adhesion and growth on the surface and (ii) stimulating biological activity such as cell growth and differentiation by the active release of component ions (Figure 1).…”

Section: Mechanism Of Action Of Bioactive Glassmentioning

confidence: 99%

Role of Zinc-Doped Bioactive Glass Encapsulated with Microspherical Gelatin in Localized Supplementation for Tissue Regeneration: A Contemporary Review

Kim

Shim

et al. 2021

Molecules

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Gelatin, a natural polymer, provides excellent tissue compatibility for use in tissue rehabilitation. Bioactive glasses (BAG) offer superior capacity in stimulating a bioactive response but show high variability in uptake and solubility. To tackle these drawbacks, a combination of gelatin with BAG is proposed to form composites, which then offer a synergistic response. The cross-linked gelatin structure’s mechanical properties are enhanced by the incorporation of the inorganic BAG, and the rate of BAG ionic supplementation responsible for bioactivity and regenerative potential is better controlled by a protective gelatin layer. Several studies have demonstrated the cellular benefits of these composites in different forms of functional modification such as doping with zinc or incorporation of zinc such as ions directly into the BAG matrix. This review presents a comprehensive perspective on the individual characteristics of BAG and gelatin, including the synthesis and mechanism of action. Further, adaptation of the composite into various applications for bone tissue engineering is discussed and future challenges are highlighted.

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Section: Mechanism Of Action Of Bioactive Glassmentioning

confidence: 99%

Role of Zinc-Doped Bioactive Glass Encapsulated with Microspherical Gelatin in Localized Supplementation for Tissue Regeneration: A Contemporary Review

Kim

Shim

et al. 2021

Molecules

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“…Si, Ca, Na and P ions are able to induce and stimulate the expression of genes related to cell differentiation and bone formation [ 14 ]. Additionally, Cu and Zn are essential trace elements for humans and can also be considered as relevant co-doping agents of silicate-based glasses for bone applications due to their important angiogenic, osteogenic and antibacterial activity [ 15 , 17 ]. A number of reviews and research studies have described the important biological role and benefits of cations like Cu 2+ and Zn 2+ for bone regeneration and bacterial control [ 14 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, Cu and Zn are essential trace elements for humans and can also be considered as relevant co-doping agents of silicate-based glasses for bone applications due to their important angiogenic, osteogenic and antibacterial activity [ 15 , 17 ]. A number of reviews and research studies have described the important biological role and benefits of cations like Cu 2+ and Zn 2+ for bone regeneration and bacterial control [ 14 , 17 , 18 , 19 , 20 ]. Our research group prepared bioactive glasses doped with Cu and Zn by the sol-gel method, which exhibited the formation of an apatite layer after immersion into a simulated body fluid (SBF) [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds

et al. 2020

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Biodegradable polymer scaffolds filled with bioactive glass particles doped with therapeutic metal ions are a novel and promising strategy to repair critical-sized bone defects. In this study, scaffolds based on a poly (D, L-lactide acid) (PDLLA) matrix filled with un-doped and Cu-, Zn- and CuZn-doped bioactive glass particles were produced by freeze-drying and a salt-leaching method. The effects of the doping and content of the glass particles (10 and 30 wt.%) on the morphology, compression properties, apatite formation, and degradation behavior of the scaffolds were evaluated. The scaffolds presented high porosity (~93%) with pores ranged from 100 to 400 μm interconnected by smaller pores and this porosity was kept after the glass particles incorporation. The glass particles reinforced the polymer scaffolds with improvements as high as 130% in elastic moduli, and further promoted the apatite formation on the scaffold surface, both properties depending on the amount and type of filler. The bioactive glass particles boosted the scaffold degradation with the PDLLA/un-doped glass scaffold showing the highest rate, but still retaining structural and dimensional integrity. Our findings show that the incorporation of un-doped and metal-doped bioactive glasses increases the mechanical strength, promotes the bioactivity and modifies the degradation profile of the resulting polymer/glass scaffolds, making them better candidates for bone repair.

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“…Bioactive glasses are attracting considerable attention for regenerative medicine and tissue engineering applications due to their excellent features in terms of bioactivity, biodegradability [ 378 ], osteogenesis [ 51 ], angiogenesis [ 11 ], antibacterial [ 95 ], anti-inflammatory [ 379 ], and immunomodulatory effects [ 380 , 381 ]. The field of ion releasing BGs for biomedical applications has been growing in the last 20 years, and several comprehensive reviews on different aspects of ion releasing BGs for biomedical use are available [ 39 – 41 , 49 , 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

Abstract: Bioactive borate glasses additionally doped with copper and/or zinc have enthralling immune-modulatory effects on immune cells.

Cited by 71 publications

References 63 publications

Role of Zinc-Doped Bioactive Glass Encapsulated with Microspherical Gelatin in Localized Supplementation for Tissue Regeneration: A Contemporary Review

Role of Zinc-Doped Bioactive Glass Encapsulated with Microspherical Gelatin in Localized Supplementation for Tissue Regeneration: A Contemporary Review

Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds

Bioactive glasses incorporating less-common ions to improve biological and physical properties

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