Cu2O acting as a robust catalyst in CuAAC reactions: water is the required medium

Green synthesis of copper nanoparticles using Ginkgo biloba L. leaf extract and their catalytic activity for the Huisgen [3 + 2] cycloaddition of azides and alkynes at room temperature

“…The solvent was removed under vacuum to give the desired pure products and characterized by 1 HNMR. All the products are known compounds and the spectral data and melting points were identical to those reported in the literature [23][24][25][26][27][28][29]. …”

Copper(I) Oxide Nanoparticles in Glycerol: A Convenient Catalyst for Cross‐Coupling and Azide–Alkyne Cycloaddition Processes

“…Chen and co‐workers described the synthesis of defined Cu 2 ONP coated with poly(vinylpyrrolidone) (PVP) in water, which were active for Cu‐catalysed 1,3‐dipolar cycloadditions 11. Unprotected Cu 2 ONP dispersed in water were also efficient for the Cu‐catalysed Huisgen cycloaddition 12…”

Benedict's solution/ vitamin C: An alternative catalytic protocol for the synthesis of regioselective‐1,4‐disubstituted‐1H‐1,2,3‐triazoles at room temperature

“…The Benedict's solution, an aqueous alkaline solution of copper(II) citrate, proved to be an important reagent in pharmaceutical and medicinal chemistry for the detection of presence of reducing sugars in urine, determination of glucose in a solution . In synthetic organic chemistry, Benedict's solution acts as a very good catalytic medium for reactions which are carried out in presence of copper source in aqueous solution . Similarly, L‐Ascorbic acid or more commonly known as vitamin C is one of the most effective alternative reducing agents, which is environmentally friendly in nature .…”