Cucurbitane triterpenoid entities derived from Hemsleya penxianensis triggered glioma cell apoptosis via ER stress and MAPK signalling cross-talk

Li, Zongyang; Chen, Meiying; Chen, Fanfan; Li, Weiping; Huang, Guodong; Xu, Xudong; Wang, Sicen; Ma, Guoxu; Cui, Ping

doi:10.1016/j.bioorg.2022.106013

Cited by 5 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The identification of these compounds was accomplished through a rigorous process involving the comparison of their mass-to-charge ratios (m/z) and the fragmentation patterns generated by MS/MS analysis. These data were meticulously matched with established databases, including the Dictionary of Natural Compounds and data from literature [24][25][26][27][28].…”

Section: Chemical Profiling Of Bitter Gourd Fruits Based On Diverse A...mentioning

confidence: 99%

“…Chemical profiling of the most effective Bitter gourd fruit cultivars (Palee and Good healthy) show that these cultivars contain higher compound intensities of the triterpenoids Xuedanoside H, Karaviloside IX and Acutoside A compared to the less effective fruit cultivars (Wild type, HMT242 and Bilai). These triterpenoids have previously been identified in Bitter gourd [24][25][26][27][28]. Xuedanoside H is a phenolic glycoside derivate which is known to be a SGLT2 inhibitor [34,35].…”

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Momordica charantia fruit reduces plasma fructosamine whereas stems and leaves increase plasma insulin in adult mildly diabetic obese Göttingen Minipigs

Koopmans,

Binnendijk,

Ledoux

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Traditionally Momordica charantia (Bitter gourd) is known for its blood glucose lowering potential. This has been validated by many previous studies based on rodent models but human trials are less convincing and the physiological mechanisms underlying the bioactivity of Bitter gourd are still unclear. The present study compared the effects of whole fruit or stems-leaves from five different Bitter gourd cultivars on metabolic control in adult diabetic obese Göttingen Minipigs. Methods Twenty streptozotocin-induced diabetic (D) obese Minipigs (body weight ~85 kg) were subdivided in mildly and overtly D pigs and fed 500 g of obesogenic diet per day for a period of three weeks, supplemented with 20 g dried powdered Bitter gourd or 20 g dried powdered grass as isoenergetic control in a cross-over, within-subject design. Results Bitter gourd fruit from the cultivars “Palee” and “Good healthy” reduced plasma fructosamine concentrations in all pigs combined (from 450±48 to 423±53 and 490±50 to 404±48 μmol/L, both p<0.03, respectively) indicating improved glycemic control by 6% and 17%. These effects were statistically confirmed in mildly D pigs but not in overtly D pigs. In mildly D pigs, the other three cultivars of fruit showed consistent numerical but no significant improvements in glycemic control. The composition of Bitter gourd fruit was studied by metabolomics profiling and analysis identified three metabolites from the class of triterpenoids (Xuedanoside H, Acutoside A, Karaviloside IX) that were increased in the cultivars “Palee” (>3.9-fold) and “Good healthy” (>8.9-fold) compared to the mean of the other three cultivars. Bitter gourd stems and leaves from the cultivar “Bilai” increased plasma insulin concentrations in all pigs combined by 28% (from 53±6 to 67±9 pmol/L, p<0.03). The other two cultivars of stems and leaves showed consistent numerical but no significant increases in plasma insulin concentrations. The effects on plasma insulin concentrations were confirmed in mildly D pigs but not in overtly D pigs. Conclusions Fruits of Bitter gourd improve glycemic control and stems-leaves of Bitter gourd increase plasma insulin concentrations in an obese pig model for mild diabetes. The effects of Bitter gourd fruit on glycemic control seem consistent but relatively small and cultivar specific which may explain the varying results of human trials reported in the literature.

show abstract

Section: Chemical Profiling Of Bitter Gourd Fruits Based On Diverse A...mentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Momordica charantia fruit reduces plasma fructosamine whereas stems and leaves increase plasma insulin in adult mildly diabetic obese Göttingen Minipigs

Koopmans,

Binnendijk,

Ledoux

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G2/M phase arrest via PI3K/AKT signaling pathway

Li,

You,

Jiang

et al. 2024

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Structurally diverse cucurbitane-type triterpenoids from the tubers of Hemsleya chinensis with cytotoxic activity

Li,

Wang,

et al. 2024

Phytochemistry

View full text Add to dashboard Cite

Cucurbitane triterpenoid entities derived from Hemsleya penxianensis triggered glioma cell apoptosis via ER stress and MAPK signalling cross-talk

Cited by 5 publications

References 45 publications

Momordica charantia fruit reduces plasma fructosamine whereas stems and leaves increase plasma insulin in adult mildly diabetic obese Göttingen Minipigs

Momordica charantia fruit reduces plasma fructosamine whereas stems and leaves increase plasma insulin in adult mildly diabetic obese Göttingen Minipigs

Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G2/M phase arrest via PI3K/AKT signaling pathway

Structurally diverse cucurbitane-type triterpenoids from the tubers of Hemsleya chinensis with cytotoxic activity

Contact Info

Product

Resources

About