Cultivated
            <i>Enterococcus faecium</i>
            B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine

There is mounting scientific evidence indicating a robust association between gut microbiota and nonalcoholic fatty liver disease (NAFLD). Exposure to commensal microbiota in germ-free mice has a significant impact on the regulatory mechanisms of gut genes, in contrast to those conventionally raised. In this study, we have successfully inoculated the gut microbiota from healthy individuals and NAFLD patients into germ-free mice, with the objective of developing a humanized mouse model that accurately replicates the gut microenvironment of NAFLD patients. Changes in blood composition and liver pathology in these mice were systematically measured. Furthermore, we have conducted a det ailed analysis of the variations in fecal microbiota and differential metabolites in the blood composition. Our findings indicate a high degree of similarity in disease characteristics between mice colonized with microbiota and humans suffering from NAFLD. Notably, we have observed a strong correlation between alterations in serum differential metabolites and gut microbiota in these mice.

show abstract

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction- associated steatotic liver disease via modulation of metabolic endotoxemia

Park,

Lee,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver disorders worldwide. Parsnip (Pastinaca sativa) has been utilized in food and medicine for centuries, owing to its high content of dietary fiber and various pharmacological properties. Although the health benefits of this root vegetable have been reported, its anti- MASLD effects remain largely understudied. Therefore, this study aimed to evaluate the prebiotic effects of a parsnip root water-soluble extract (PRE) and its alleviatory effects against MASLD and metabolic endotoxemia in a mouse model. Mice were fed a high-fat diet supplemented with 50 and 100 mg/kg of PRE for eight weeks. Mice administered with PRE exhibited reduced fat accumulation and serum metabolic changes that were associated with liver injury. Furthermore, PRE treatment reduced the hepatic lipogenic protein levels that were elevated by the high-fat diet. This extract improved intestinal barrier function by modulating endotoxin, intestinal permeability, and tight junction protein expression. This confirms that PRE is associated with improved gut health. These findings suggest that oral administration of PRE may prevent MASLD and improve metabolic health, which can facilitate the use of this extract as a dietary supplement.

show abstract

Cultivated Enterococcus faecium B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine

Cited by 4 publications

References 83 publications

Comparative genomic and metabolomic analysis reveals the potential of a newly isolated Enterococcus faecium B6 involved in lipogenic effects

Comparative genomic and metabolomic analysis reveals the potential of a newly isolated Enterococcus faecium B6 involved in lipogenic effects

Exploring the Pathogenesis of NAFLD: A Study of the Correlation of Gut Microbes and Metabolites in Humanized Mouse Gut Microbiota

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction- associated steatotic liver disease via modulation of metabolic endotoxemia

Contact Info

Product

Resources

About