Culture-negative pleural empyema after Coronavirus disease-19 resolution – A case report

Abstract

Even after more than a year, novel Coronavirus disease-19 (COVID-19) clinical presentation and complications are still being reported. We present a 75-year-old patient with culture-negative pleural empyema a month after COVID-19 resolution without re-infection. We hypothesize that culture-negative empyema can be present in patients with immune defect, e.g., elderly or diabetic patients, and prior antibiotic exposure. Empyema after COVID-19 resolution may be related to delayed inflammation improvement in chronic disease, which resulted in the patient's more vulnerability to secondary infection.

Case Report: Actinomyces meyeri empyema in a COVID-19 positive patient with history of testicular mixed germ cell tumor

“…While, to this date, there have been no other reports of patients with concurrent COVID-19 and Actinomyces meyeri infection within the literature, empyema in relation with COVID-19 positive patients have primarily been seen in hosts who are immunocompromised, have autoimmune diseases, or have had prior antibiotic exposure. 18 SARS-CoV studies have demonstrated that the virus infects epithelial cells in the lung which induces interleukin-8 (IL-8) production. 18 IL-8, a prominent interleukin in attracting T-cells and neutrophils, recruits a large number of inflammatory cells which are able to further induce damage to weaken the lung parenchyma.…”

“…18 SARS-CoV studies have demonstrated that the virus infects epithelial cells in the lung which induces interleukin-8 (IL-8) production. 18 IL-8, a prominent interleukin in attracting T-cells and neutrophils, recruits a large number of inflammatory cells which are able to further induce damage to weaken the lung parenchyma. 19 We considered that in our patient with adequate oral hygiene and no history of alcoholism, the recent hospitalization and the concurrent COVID-19 infection were the most important risk factors for the A. meyeri empyema infection.…”

Tracheo‐esophageal fistula and pleural empyema in the course of SARS‐CoV‐2 infection—A case report

“…In the first stage of a pleural empyema, the optimal treatment may be appropriate antibiotic therapy and pleural drainage. 8 This approach in the treatment of a pleural empyema in the course of SARS‐CoV‐2 infection has proven effective in the patients described by Zavin et al and Silalahi et al 17 , 18 …”

“…In the first stage of a pleural empyema, the optimal treatment may be appropriate antibiotic therapy and pleural drainage. 8 This approach in the treatment of a pleural empyema in the course of SARS-CoV-2 infection has proven effective in the patients described by Zavin et al and Silalahi et al 17,18 Regarding the surgical approach, video-assisted thoracic surgery (VATS) is considered the "gold standard for the surgical management of an empyema." 19 VATS enables the proper decortication of an empyema as effectively as thoracotomy, and is associated with less pain and, at the same time, greater patient acceptance.…”

Kelembagaan Badan Usaha Milik Desa (Bumdes) Dan Pengaruhnya Terhadap Kemiskinan Rumah Tangga Di Kabupaten Donggala Pada Masa Pandemi Covid-19

“…BUMDes sebagai lembaga yang dibentuk untuk mensejahterakan masyarakat mengalami dampak yang cukup signifikan dimasa pandemi covid-19 (Stafford, Parchem, and Sibai 2021;Silalahi and Suwita 2021). Persoalan ekonomi yang dihadapi oleh BUMDes maupun masyarakat semakin kompleks akibat pendemi COVID-19.…”