Curative resection plus adjuvant chemotherapy for early stage primary gastric non-Hodgkin's lymphoma: a retrospective study with emphasis on prognostic factors and treatment outcome

Abstract

-Background -There is controversy regarding the optimal therapy for primary non-Hodgkin gastric lymphoma with some authors defending surgical extirpation either alone or in association with radiotherapy and or chemotherapy, especially in relation to the earlier stages of the disease. Aim -To analyze the clinical-pathological features and the results of management approaches for patients with primary early-stage non-Hodgkin's lymphoma of the stomach operated in Surgical Gastroenterology Department, "Hospital do Servidor Público Estadual", São Paulo, SP, Brazil. The literature is reviewed to highlight the aspects of diagnosis, prognostic factors and role of the various treatment regimens. Method -Sixteen patients with primary early-stage gastric lymphoma underwent curative surgical treatment. The variables analyzed were age, sex, location, size, type of surgery, number of lesions, depth of invasion, histological type in accordance with Kiel's classification, involvement of lymph nodes, Ann Arbor stage classification modified by Musshoff and Schmidt-Vollmer, histological grade, margins, adjuvant therapy, clinical course and survival. Results -Ten patients (62.5%) underwent subtotal gastrectomy and six (37.5%) underwent total gastrectomy. The majority (9/56.2%) of the lesions were located in the antrum. Single lesions (10/62.5%) were more frequent than multiple lesions (6/37.5%). Thirteen patients (81.2%) were classified as stage IE and three (18.7%) as stage IIE1. Primary gastric lymphoma classified histologically as low or high grade was presented by 10 (62.5%) and 6 (37.5%) patients, respectively. The most frequent histological types were the lymphoplasmocytic cytoid (4/25.0%) and centroblastic (4/25.0%). Ten patients (62.5%) received adjuvant treatment (chemotherapy and/or radiotherapy). Nine patients (56.2%), all in stage IE, reached a survival greater than 5 years and of these eight (50.0.%) had received adjuvant therapy. Two (12.5%) patients with stage IIE1 presented peritoneal relapse and died 3.0 years and 3.5 years after their respective operations. The mean overall survival was 42,5 months. Conclusions -Among the patients with primary early-stage gastric lymphoma (IE and IIE1), the gastric resection enabled an accurate clinicopathological staging, in addition to obtaining sufficient material for histopathological study and extirpation of the lesion. Furthermore, for patients with stage IE disease, the gastric resection combined with adjuvant therapy was associated with a greater than 5-year survival. Until prospective randomized studies are realized in order to evaluate the real efficacy of the different types of treatment for primary early-stage gastric lymphoma, management approaches should be individually tailored. HEADINGS -Lymphoma. Non-Hodgkin's lymphoma. Gastric neoplasms. Prognostic factors. Survival. lymphomas, mucosa-associated lymphoid tissue (MALT) and low-grade lymphomas (12,16,27,28,31) . Due to the relative rarity of the tumor, few centers have accumulated an adequate number of pat...

Surgery for non-Hodgkin’s lymphoma

“…For the advanced stages (IIE2-IV), primary chemotherapy is the best treatment option with surgery being reserved for cytoreduction or chemo-radiotherapy-induced complications. 35 …”

Perforación gástrica por linfoma MALT. Reporte de caso

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“…La presencia de monoclonalidad no equivale a malignidad, pudiendo haber monoclonalidad sin linfoma o persistir esta durante un tiempo tras la desaparición del tumor 1,2,4,8 .…”

“…En determinados linfomas de alto grado no se aprecia ningún signo de lesión de bajo grado, por lo que estos tumores pueden considerarse de alto grado «de novo». No obstante, este dato carece de valor pronóstico ya que no existen diferencias clínicas con los linfomas que progresan de bajo a alto grado 1,2,8 .…”

Mirizzi syndrome in an anomalous cystic duct: A case report

“…Many cases have so far been reported, and various operations have been suggested depending on the types of MS. Laparoscopic cholecystectomy has become the standard operation for gallstones, and many authors have adopted this operation for typeⅠMS. However, high rates of conversion and bile duct injury indicate that this is not a safe treatment modality for MS, especially when combined with a cystic duct anomaly [2][3][4][5] . In this report, we present a case of type ⅠMirizzi syndrome, complicated by a rare anomalous cystic duct, which was operated with an open procedure.…”