Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Malik, Minnie; Mendoza, Mirian; Payson, M.; Catherino, William H.

doi:10.1016/j.fertnstert.2008.03.045

Cited by 53 publications

(48 citation statements)

References 65 publications

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“…In addition to miR-200c, several other miRNAs have been predicted to target IKBKB and IL8 expression, of which miR-199a and miR-218 were validated to regulate IL8 through IKBKB [15], [17], [35], and miR-17/20, miR-93/106b, miR-146a/b and miR-155 directly targeted IL8 expression or IL8-mediated inflammation, senescence and cellular invasion [13], [25], [27], [36]. In support of our observations, other reports have demonstrated the presence of NF-kB p50 and p65 proteins in leiomyoma cells [37] and elevated IL8 mRNA level in leiomyoma with stronger immunoreactive IL8 in the edge of leiomyoma adjacent to myometrium [38], [39]. As such, an increase in NF-kB dependent- regulation of inflammatory-related genes expression, including IL8, further support the potential role of inflammatory events in the pathogenesis of leiomyomas [1].…”

Section: Discussionsupporting

confidence: 90%

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

Chuang

Khorram

2014

PLoS ONE

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We have previously reported that leiomyoma expressed lower levels of miR-200c and elevated IL8 as compared to paired myometrium. Here we addressed the regulatory functions of miR-200c on the expression of inflammatory mediators and cellular viability using leiomyomas and paired myometrium and their isolated primary smooth muscle cells. Our results indicated that gain-of function or knockdown of miR-200c in leiomyoma smooth muscle cells (LSMC) regulated IL8 mRNA and protein expression through direct targeting of IKBKB and alteration of NF-kB activity. Additionally, leiomyoma expressed higher levels of phosphorylated IKBKB with no significant difference in the level of IKBKB mRNA and protein as compared to matched myometrium. Gain-of function of miR-200c in LSMC resulted in decreased IkBαphosphorylation and p65 nuclear translocation, which led to decreased p65 transcriptional activity of IL8 promoter, and increased caspase 3/7 activity which was not reversible following IL8 restoration. Collectively, our results suggest that NF-κB signaling pathway is a target of miR-200c regulatory function, and low level of miR-200c expression in leiomyoma by transcriptional regulation of inflammatory mediators such as IL8, in part account for development of leiomyomas.

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Section: Discussionsupporting

confidence: 90%

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

Chuang

Khorram

2014

PLoS ONE

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“…Cranberry may promote a cellular environment with less oxidative damage, which in turn results in less active MAPK signaling. Consistent with our findings, curcumin treatment reduced the ERK1/2 protein level in leiomyoma cells from patients with symptomatic leiomyomata (Malik et al, 2009). More mechanistic studies are needed to pinpoint signaling pathways and genome-wide epigenetic status, which are directly affected by cranberry supplementation.…”

Section: Discussionsupporting

confidence: 91%

Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent

Sun

Yolitz

Alberico

et al. 2014

Experimental Gerontology

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Many nutraceuticals and pharmaceuticals have been shown to promote healthspan and lifespan. However, the mechanisms underlying the beneficial effects of prolongevity interventions and the time points at which interventions should be implemented to achieve beneficial effects are not well characterized. We have previously shown that a cranberry-containing nutraceutical can promote lifespan in worms and flies and delay age-related functional decline of pancreatic cells in rats. Here we investigated the mechanism underlying lifespan extension induced by cranberry and the effects of short-term or life stage-specific interventions with cranberry on lifespan in Drosophila. We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of ERK, a component of oxidative stress response MAPK signaling, and slightly increased phosphorylation of AKT, a component of insulin-like signaling. Lifespan extension was also associated with a reduced level of 4-Hydroxynonenal protein adducts, a biomarker of lipid oxidation. Moreover, lifespan extension induced by cranberry was partially suppressed by knockdown of SOD2, a major mitochondrial superoxide scavenger. Furthermore, cranberry supplementation was administered in three life stages of adult flies, health span (3–30 days), transition span (31–60 days) and senescence span (61 days to the end when all flies died). Cranberry supplementation during any of these life stages extended the remaining lifespan relative to the non-supplemented and life stage-matched controls. These findings suggest that cranberry supplementation is sufficient to promote longevity when implemented during any life stage, likely through reducing oxidative damage.

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“…In addition to its role as a potentially potent chemosensitizer, curcumin is also a promising radiosensitizer in a wide variety of cancer cells (52–55). Curcumin has also been shown to suppress the growth of numerous cancer cells, including those from cancer cells of the prostate (56), biliary (57), pituitary gland (58), oral (59), and uterine leiomyoma (60). …”

Section: Biological Activities Of Curcuminmentioning

confidence: 99%

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

Gupta

Patchva

Koh

et al. 2012

Clin Exp Pharma Physio

722

460

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SUMMARY 1. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years. Modern science has shown that curcumin modulates various signaling molecules, including inflammatory molecules, transcription factors, enzymes, protein kinases, protein reductases, carrier proteins, cell survival proteins, drug resistance proteins, adhesion molecules, growth factors, receptors, cell-cycle regulatory proteins, chemokines, DNA, RNA, and metal ions. 2. Because of this polyphenol's potential to modulate multiple signaling molecules, it has been reported to possess pleiotropic activities. First shown to have anti-bacterial activity in 1949, curcumin has since been shown to have anti-inflammatory, anti-oxidant, pro-apoptotic, chemopreventive, chemotherapeutic, anti-proliferative, wound healing, anti-nociceptive, anti-parasitic, and anti-malarial properties as well. Animal studies have suggested that curcumin may be active against a wide range of human diseases, including diabetes, obesity, neurologic and psychiatric disorders, and cancer, as well as chronic illnesses affecting the eyes, lungs, liver, kidneys, and gastrointestinal and cardiovascular systems. 3. Although many clinical trials evaluating curcumin's safety and efficacy against human ailments have already been completed, others are still ongoing. Moreover, curcumin is used as a supplement in several countries, including India, Japan, the United States, Thailand, China, Korea, Turkey, South Africa, Nepal, and Pakistan. Although inexpensive, apparently well tolerated, and potentially active, curcumin has yet not been approved for treatment of any human disease. 4. In this article, we discuss the discovery and key biological activities of curcumin, with a particular emphasis on its activities at the molecular, cellular, animal, and human levels.

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Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Cited by 53 publications

References 65 publications

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

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