Curcumin, a potential oral herbal male contraceptive: a review article

Abstract

Background: Worldwide, the population explosion and unintended pregnancies pose serious health issues. The family planning program is a vital element due to reducing population growth. Demographic data and family planning in Indonesia report that contraceptive use rates are 93.66% for women and 6.34% for men. Men's participation in family planning programs remains low, with options limited to vasectomy and condoms. Limited contraceptive options may explain the low participation rate. WHO recommends traditional medicine as a cost-effective substitute for manufactured medicines. The primary ingredient in turmeric, Curcumin, has antiviral, antibacterial, anti-inflammatory, and anticancer activities. In both animal and human clinical trials, it has demonstrated a lack of toxicity. Little research has been done on how it affects the male reproductive. Objective: This article reviews the literature regarding the effects of Curcumin in Curcuma Longa on male fertility. Conclusion: Curcumin in Curcuma Longa causes noticeable changes in the male reproductive system that reverse when treatment is discontinued. Therefore, Curcumin may potentially control male fertility as a male contraceptive.

Hepatitis E Inhibited by Rosmarinic Acid Extract from Clove Plant (Syzygium Aromaricum) through Computational Analysis

“…Many previous studies have focused on in vitro or in vivo testing, while this research employs computational approaches to identify the potential of inhibitors without the need for complex laboratory testing. This computational approach offers advantages in accelerating the discovery process of new inhibitor potentials, thus serving as a strong initial foundation for the development of potential therapies for Hepatitis E. [44][45][46][47][48][49][50][51][52][53][54][55][56][57] Overall, this research provides new contributions to the development of therapies for Hepatitis E through computational approaches.…”

Testaments of Female Natural Contraceptives: An Update on the Usage of African Herbal Remedies

“…Curcumin is known to be present in Curcuma longa, Researches have demonstrated its anti-fertility property by impeding implantation and disrupting the female reproductive cycle. [26][27][28]…”

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“…Furthermore, the safety and efficacy of Curcuma longa as an antimicrobial need to be validated through comprehensive clinical trials. It is envisaged that with advanced research and technology, the full potential of Curcuma longa as a natural antimicrobial agent can be realized [33][34][35][36][37].…”