Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats

Man, Shuli; Li, Jing; Liu, Jing; Chai, Hongyan; Liu, Zhen; Wang, Jiaming; Gao, Wenyuan

doi:10.1002/tox.22194

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…Rhizoma paridis saponins (RPS) played a good anti‐tumour role in many clinical applications. Combination of RPS and CUR not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumour cells and enhanced their anti‐cancer effect . In our previous research, PSII (formosanin C) as one of the main effective compounds in RPS was absorbed in rat plasma after oral administration of RPS .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly in our previous research, CUR not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumour cells and enhanced their anti‐cancer effect . With the widely application of complex mixtures in clinic, the aim of this study was to investigate the synergistic anti‐cancer effects of PSII and CUR in lung cancer cell lines.…”

Section: Introductionmentioning

confidence: 97%

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Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

et al. 2018

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“…Acute toxicity test was performed as per OECD guideline 423 for testing of chemicals ( 2001) [5]. Healthy young adult rats, non-preg-nant female rats weighing about 150-200 g were administered only once orally at a single doses of 2000 mg/kg bw and 5000 mg/kg bw of ethanol extract of pirdot leaves, whereas the control group only received Na CMC 0.5%.…”

Section: Acute Toxicity Studymentioning

confidence: 99%

“…Secondary metabolites such as saponins and polyphenols can have adverse effects such as causing poisoning when overused. Polyphenols 0.5% -1% show hepatotoxic and nephrotoxic effects 4 and saponins can cause serious damage to the liver and kidneys 5 . Unexpected adverse effects of these secondary metabolites can occur due to increased Reactive Oxygen Species (ROS) in the body that will trigger the release of acrolein, malondialdehyde and 4-hydroxy-2nonenal, causing disruption of normal protein function which has an impact on changes in cell activity [4], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats

Simanjuntak¹,

Rosidah²,

Yuandani³

2020

idjpcr

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Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.

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“…10 Studies had shown that curcumin could antioxidant, anti-inflammatory, anti-cancer, protected nervous system, controlled obesity, and diabetes. [11][12][13][14][15][16][17] Among them, curcumin had excellent antioxidant performance. Curcumin exerted antioxidant effect by regulating the expressions of superoxide dismutase (SOD), heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2), thus protecting the arteries and improving the arterial health.…”

Section: Introductionmentioning

confidence: 99%

Curcumin alleviates ketamine‐induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus

Zhang

Cui

Song

et al. 2022

Environmental Toxicology

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Aims: To investigate curcumin's protective effect on nerve damage caused by ketamine anesthesia via the Nrf2 signaling pathway. Rats and PC12 cells were used in this experiment to investigate the mechanism of nerve injury caused by ketamine anesthesia. Furthermore, our findings suggest that curcumin may affect oxidative stress and apoptosis by targeting the Nrf2 pathway, thereby alleviating the nerve injury caused by ketamine. Methods:The rat cerebral cortex and hippocampus were stained with Nissl and immunohistochemistry to determine the number of neurons and the expression of Caspase-3, Bcl-2, and Bax. CCK-8 assay was used to determine the optimal concentration of ketamine, curcumin, and H 2 O 2 in PC12 cells. Flow cytometry was used to detect changes in reactive oxygen species and the rate of apoptosis in each group.To determine whether Nrf2 entered the nucleus, immunofluorescence was used.Both tissues and cells were subjected to RT-PCR and Western blotting detection at the same time. The levels of oxidative stress were determined using a malondialdehyde (MDA) and superoxide dismutase (SOD) assay kit.Results: Ketamine reduced the number of neurons in the cortex and hippocampus of rats. The proteins Bax and Caspase-3 were upregulated, while Bcl-2 was downregulated in the cortex and hippocampus. The viability of PC12 cells has decreased.MDA content increased while SOD activity decreased in cortex, hippocampus, and PC12 cells. Ketamine had an effect on the expression of some genes in the Nrf2 signaling pathway as well as apoptosis. Curcumin pretreatment may be able to prevent ketamine-induced damage. Conclusions:The oxidative stress and apoptosis caused by ketamine during growth of the cerebral cortex, hippocampus, and PC12 cells may be decreased by curcumin's activation of the Nrf2 signaling pathway. Our research provides a potential strategy for the secure administration of anesthetics in medical settings.

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Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats

Cited by 7 publications

References 18 publications

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats

Curcumin alleviates ketamine‐induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus

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