Curcumin: An epigenetic regulator and its application in cancer

Ming, Tianqi; Qiu, Tao; Tang, Shun; Zhao, Hui; Liu, Maolun; Ren, Shan; Xu, Haibo

doi:10.1016/j.biopha.2022.113956

Cited by 59 publications

(22 citation statements)

References 202 publications

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“…Recent studies have demonstrated that plant‐derived natural products have great potential in the treatment of epigenetic characteristics of cancer (Fang et al, 2020; D. Huang et al, 2019). Plant‐derived natural products are considered to promise epigenetic drugs for tumor prevention and treatment in the future, such as protoberberine alkaloids, flavones, polyphenols, and cyclic peptides, which have been evaluated in clinical trials (Fang et al, 2020; Karaman Mayack et al, 2020; Ming et al, 2022; Nowrasteh et al, 2023; Pontes et al, 2023). Up to now, natural products are increasingly becoming the focus of research in the field of tumor therapy and new drug discovery.…”

Section: Antitumor Effect Of Natural Productsmentioning

confidence: 99%

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Zhang,

Wang,

Qin

et al. 2024

Phytotherapy Research

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Cancer is a highly heterogeneous disease that poses a serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, the prognosis and survival rate of cancer remain poor due to late diagnosis, drug resistance, and adverse reactions. Therefore, it is very necessary to study the development mechanism of cancer and formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by targeting abnormal epigenetic changes. The main active part of garlic is organic sulfur compounds, of which diallyl trisulfide (DATS) content is the highest, accounting for more than 40% of the total composition. The garlic‐derived compounds have been recognized as an antioxidant for cancer prevention and treatment. However, the molecular mechanism of the antitumor effect of garlic‐derived compounds remains unclear. Recent studies have identified garlic‐derived compound DATS that plays critical roles in enhancing CpG demethylation or promoting histone acetylation as an epigenetic inhibitor. Here, we review the therapeutic progress of garlic‐derived compounds against cancer through epigenetic pathways.

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Section: Antitumor Effect Of Natural Productsmentioning

confidence: 99%

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Zhang,

Wang,

Qin

et al. 2024

Phytotherapy Research

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“…Curcumins contain different medicinal values such as antioxidant, anti-pulmonary fibrosis, anti-inflammation, antiviral, and chronic obstructive pulmonary disease impacts, and attractively docked with multi-target molecular proteins related to diabetes [ 489 , 490 , 491 , 492 , 493 , 494 ]. Curcumin is insoluble in water and easily efficient in organic solvents [ 495 ]; the active functional groups of curcumin can be oxidized by electron transfer and hydrogen abstraction [ 496 ], and curcumin is more durable in acidic to neutral conditions than in alkaline circumstances [ 495 , 496 , 497 ]. Curcumin, as an enzyme inhibitor, has proper structural characteristics including a flexible backbone, hydrophobic nature, and different available hydrogen bond (H-bond) donors and acceptors [ 498 ].…”

Section: The Health Benefits Of Curcuminoids (Curcumin Demethoxycurcu...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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“…Hitherto, curcuminoids have been shown to be effective in various pathological states [343][344][345][346][347][348][349][350][351][352] including malignancies. [353][354][355][356][357] Nevertheless, despite the long history of research, the therapeutic targets and signaling cascades altered by curcumin are still a mystery. 297,358,359 Curcumin was proven to suppress the protease activities of the proteasome since it was initially reported in 1995 to prevent the activation of proinflammatory transcription factor NF-κB by preventing the 26S proteasomal degradation of IκB.…”

Section: Curcuminmentioning

confidence: 99%

“…In addition to flavonoid phytochemicals, several non‐flavonoid phytochemicals like curcumin and resveratrol, have been revealed to possess proteasome‐inhibitory action in multiple cancers. Hitherto, curcuminoids have been shown to be effective in various pathological states 343–352 including malignancies 353–357 . Nevertheless, despite the long history of research, the therapeutic targets and signaling cascades altered by curcumin are still a mystery 297,358,359 .…”

Section: The Mechanistic Role Of Phytochemicals Targeting Ups In Cancermentioning

confidence: 99%

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

et al. 2023

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Regarding the multimechanistic nature of cancers, current chemo‐ or radiotherapies often fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur. Brain malignancies, particularly glioblastomas, are difficult‐to‐treat cancers due to their highly malignant and multidimensional biology. Unfortunately, patients suffering from malignant tumors often experience poor prognoses and short survival periods. Thus far, significant efforts have been conducted to discover novel and more effective modalities. To that end, modulation of the ubiquitin‐proteasome system (UPS) has attracted tremendous interest since it affects the homeostasis of proteins critically engaged in various cell functions, for example, cell metabolism, survival, proliferation, and differentiation. With their safe and multimodal actions, phytochemicals are among the promising therapeutic tools capable of turning the operation of various UPS elements. The present review, along with an updated outline of the role of UPS dysregulation in multiple cancers, provided a detailed discussion on the impact of phytochemicals on the UPS function in malignancies, especially brain tumors.

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Curcumin: An epigenetic regulator and its application in cancer

Cited by 59 publications

References 202 publications

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

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