Curcumin and Biodegradable Membrane Promote Nerve Regeneration and Functional Recovery After Sciatic Nerve Transection in Adult Rats

Moattari, Mehrnaz; Moattari, Farahnaz; Kouchesfahani, Homa Mohseni; Kaka, Gholamreza; Sadraie, Seyed Homayoon; Naghdi, Majid; Mansouri, Korosh

doi:10.1097/sap.0000000000001566

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…These markers are indicative of increased SC recruitment and promyelinating activity. As such, an increase in myelin thickness [ 34 , 40 , 41 , 66 , 69 , 70 , 76 , 80 ] and axon diameter [ 34 , 66 , 70 , 74 , 76 , 80 ] is observed with curcumin treatment. Also, of note is the proposed involvement of extracellular signal-regulated kinase (ERK) and p38 kinases [ 35 ].…”

Section: Curcumin Mechanisms Of Action and Cellular Targets In Thementioning

confidence: 99%

“…Some other ways of assessing nerve regeneration are by looking at nerve fibers regrowth and functional recovery. As seen in the DRG, after curcumin treatment, the number of sciatic nerve fiber increased [ 66 , 69 , 74 , 80 ] in rodent models of sciatic nerve transection, nerve crush injury, and even complete sciatic nerve amputation. The sciatic functional index (SFI) also improved in the above models [ 66 , 69 , 76 ].…”

Section: Curcumin Mechanisms Of Action and Cellular Targets In Thementioning

confidence: 99%

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Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

et al. 2020

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Peripheral neuropathies (PN) can be triggered after metabolic diseases, traumatic peripheral nerve injury, genetic mutations, toxic substances, and/or inflammation. PN is a major clinical problem, affecting many patients and with few effective therapeutics. Recently, interest in natural dietary compounds, such as polyphenols, in human health has led to a great deal of research, especially in PN. Curcumin is a polyphenol extracted from the root of Curcuma longa. This molecule has long been used in Asian medicine for its anti-inflammatory, antibacterial, and antioxidant properties. However, like numerous polyphenols, curcumin has a very low bioavailability and a very fast metabolism. This review addresses multiple aspects of curcumin in PN, including bioavailability issues, new formulations, observations in animal behavioral tests, electrophysiological, histological, and molecular aspects, and clinical trials published to date. The, review covers in vitro and in vivo studies, with a special focus on the molecular mechanisms of curcumin (anti-inflammatory, antioxidant, anti-endoplasmic reticulum stress (anti-ER-stress), neuroprotection, and glial protection). This review provides for the first time an overview of curcumin in the treatment of PN. Finally, because PN are associated with numerous pathologies (e.g., cancers, diabetes, addiction, inflammatory disease...), this review is likely to interest a large audience.

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Section: Curcumin Mechanisms Of Action and Cellular Targets In Thementioning

confidence: 99%

Section: Curcumin Mechanisms Of Action and Cellular Targets In Thementioning

confidence: 99%

Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

et al. 2020

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“…After PNI, curcumin was able to reduce cell loss [ 27 ], improve the action, potential amplitude and conduction velocity [ 28 ], improve mechanical sensitivity [ 29 ], functional assessments [ 29 , 31 , 32 , 35 ], motor and sensitive nerve conduction velocity [ 29 ], axonal regeneration [ 32 , 34 ], myelination [ 29 , 31 , 33 ], and therefore improved the diameter of nerve fibers [ 31 ], reduce reactive oxygen species [ 29 , 35 ], lipid peroxidation [ 29 ] and cell death [ 35 ], and expedite the reversal of mechanical allodynia [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Abushukur¹,

Knackstedt²

2022

Cureus

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Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury, and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating weakness, numbness, paresthesia, pain, and/or autonomic instability. As PNI is associated with inflammation and nerve degeneration, means to mitigate this response could result in improved outcomes. Numerous nutrients have been investigated to prevent the negative sequelae of PNI. Alpha-lipoic acid, cytidine diphosphate-choline (CDP Choline), curcumin, melatonin, vitamin B12, and vitamin E have demonstrated notable success in improving recovery following PNI within animal models. While animal studies show ample evidence that various supplements may improve recovery after PNI, similar evidence in human patients is limited. The goal of this review is to analyze supplements that have been used successfully in animal models of PNI to serve as a reference for future studies on human patients. By analyzing supplements that have shown efficacy in animal studies, healthcare providers will have a resource from which to guide decision-making regarding future human studies investigating the role that supplements could play in PNI recovery. Ultimately, establishing a comprehensive understanding of these supplements in human patients following PNI may significantly improve post-surgical outcomes, quality of life, and peripheral nerve regeneration.

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“…It was noted that the conduit could serve as suitable matrix for stem cell transplantation for in vivo nerve regeneration and the authors concluded that due to presence of PUAO and CS in a single conduit, cell proliferation was enhanced and showed potential to be used in vivo peripheral nerve regeneration. Moattari et al [ 163 ] reported the use of curcumin and chitosan membrane for peripheral nerve injuries. Curcumin is obtained from a plant named Curcuma which is known to have anti-inflammatory and antioxidant properties.…”

Section: Bioengineering Approaches To Regenerating Cns and Pnsmentioning

confidence: 99%

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

2021

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Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells. ROS play both beneficial and detrimental roles in human physiology depending on their overall concentration. ROS are an inevitable byproduct of the normal functioning of cells, which are produced as a result of the mitochondrial respiration process. Since the establishment of the detrimental effect of oxidative stress in neurological disorders and neurotrauma, there has been growing interest in exploring antioxidants to rescue remaining or surviving cells and reverse the neurological damage. In this review, we present the survey of different antioxidants studied in neurological applications including neurotrauma. We also delve into bioengineering approaches developed to deliver antioxidants to improve their cellular uptake in neurological applications.

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Curcumin and Biodegradable Membrane Promote Nerve Regeneration and Functional Recovery After Sciatic Nerve Transection in Adult Rats

Abstract: The present study showed the positive effects of Mem + Cur on nerve regeneration of transected sciatic nerve in rat model.

Cited by 8 publications

References 17 publications

Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

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