Curcumin and Its Potential Impact on Microbiota

Jabczyk, Marzena; Nowak, Justyna; Hudzik, Bartosz; Zubelewicz-Szkodzińska, Barbara

doi:10.3390/nu13062004

Cited by 57 publications

(40 citation statements)

References 42 publications

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“…Curcumin metabolites exhibit the same physiological and pharmacological properties, and also have similar properties and potency [ 16 , 23 ]. Curcumin is metabolized mainly in the liver, together with the intestine and gut microbiota (GM) [ 28 ]. Enzymes of the large intestine metabolize curcumin and this occurs in two phases ( Figure 1 ).…”

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in Curcuma longa L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.

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Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…In the review by Marzena Jabczyk et al [ 11 ], the data on the relationship between curcumin and microbiota are further expanded, considering the association between curcumin-induced changes in gut microbiota and attenuation of a number of diseases. The modulation of gut microbiota induced by curcumin treatment seems to be associated with an improvement of liver diseases, such as non-alcoholic fatty liver, as well as of metabolic health restoring a beneficial microbiota profile that is found altered in the course of metabolic disorders such as obesity and diabetes.…”

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confidence: 99%

Curcumin: A Promising Tool to Develop Preventive and Therapeutic Strategies against Non-Communicable Diseases, Still Requiring Verification by Sound Clinical Trials

Masella

Cirulli

2022

Nutrients

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“…Gut bacteria, for example, convert genistein, soy’s most abundant isoflavone, into several metabolites that target and alter estrogen-dependent and non-estrogenic pathways with a variety of biological activities. As such, individual differences in the microbiome, therapeutic possibilities, and anticancer effects may be unique to each person [ 101 , 102 , 103 ]. Overall, these variables hinder the clinical development of dietary phytochemicals.…”

Section: Pharmacokinetics and Bioavailabilitymentioning

confidence: 99%

Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment

Prajapati

Gupta

Kumar

2022

Cancers

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Breast cancer is heterogeneous disease with variable prognosis and therapeutic response. Approximately, 70% of diagnosed breast cancer represents the luminal A subtype. This subpopulation has a fair prognosis with a lower rate of relapse than the other clinical subtypes. Acquisition of stemness in luminal A subtype modifies the phenotype plasticity to accomplish increased aggressiveness and therapeutic resistance. Therefore, targeting luminal A-derived breast cancer stem cells (BCSCs) could be a promising strategy for its prevention and treatment. Extensive studies reveal that dietary phytochemicals have the potential to target BCSCs by modulating the molecular and signal transduction pathways. Dietary phytochemicals alone or in combination with standard therapeutic modalities exert higher efficacy in targeting BCSCs through changes in stemness, self-renewal properties and hypoxia-related factors. These combinations offer achieving higher radio- and chemo- sensitization through alteration in the key signaling pathways such as AMPK, STAT3, NF-ĸB, Hedgehog, PI3K/Akt/mTOR, Notch, GSK3β, and Wnt related to cancer stemness and drug resistance. In this review, we highlight the concept of targeting luminal A-derived BCSCs with dietary phytochemicals by summarizing the pathways and underlying mechanism(s) involved during therapeutic resistance.

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Curcumin and Its Potential Impact on Microbiota

Cited by 57 publications

References 42 publications

Curcumin and Weight Loss: Does It Work?

Curcumin and Weight Loss: Does It Work?

Curcumin: A Promising Tool to Develop Preventive and Therapeutic Strategies against Non-Communicable Diseases, Still Requiring Verification by Sound Clinical Trials

Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment

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