Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial

Yousefi-Nodeh, Hamidreza; Farshbaf‐Khalili, Azizeh; Oskouei, Behnaz Sadeghzadeh; Jafarilar-Aghdam, Nayyer; Kazemi-Zanjani, Negin; Pourzeinali, Samira

doi:10.1080/07399332.2022.2117815

Cited by 2 publications

(2 citation statements)

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“…In addition, P. granatum is a considerable source of vitamin C, and its seeds contain abundant amount of vitamin E, which can ameliorate HFs (Aksoz et al, 2020; Yousefi‐Nodeh et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Moeini,

Shirafkan,

Gorji

2023

Phytotherapy Research

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Pomegranate is widely used to preserve human health and help prevent many kinds of diseases. This study aims to review and assess the effects of pomegranate on women's health during and after menopause. PubMed, Web of science, Cochrane, Scopus, and Google Scholar were searched up to the end of 2022 with no language or study type restriction. All types of clinical research studies (randomized clinical trial [RCT], pre–post, case report, and case series) were included. The Cochrane RoB 2.0 tool was used for quality assessment of RCTs. A summary of intervention's effects for each study was provided by calculating standardized mean differences and accompanying 95% confidence interval using random effect model. Weighted mean differences and heterogeneity between studies were assessed using Hedges's method and Cochran's Q test, respectively. Pomegranate can significantly improve hot flashes severity and menopause symptoms and decrease FSH. It significantly improves high‐density lipoprotein but not low‐density lipoprotein, body mass index, and weight. Most of our results are inconclusive, and the small sample sizes and the lack of blinding and randomization have led to an increased risk of bias. Pomegranate can decrease menopause symptoms, but more well‐designed studies, with bigger sample sizes are needed to establish its other clinical benefits for menopausal women.

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Section: Discussionmentioning

confidence: 99%

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Moeini,

Shirafkan,

Gorji

2023

Phytotherapy Research

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“…Yousefi-Nodeh et al (2022) showed that curcumin and vitamin E improve hot flashes in postmenopausal women. The presumed mechanism of action of curcumin and vitamin E is associated with the reduction in inflammation and oxidative stress [ 30 ].…”

Section: Inflammatory and Oxidative Stress Biomarkersmentioning

confidence: 99%

Menopause Hot Flashes and Molecular Mechanisms Modulated by Food-Derived Nutrients

Forma,

Urbańska,

Bryś

2024

Nutrients

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The causes of vasomotor symptoms, including hot flashes, are not fully understood, may be related to molecular factors, and have a polygenic architecture. Nutrients and bioactive molecules supplied to the body with food are metabolized using various enzymatic pathways. They can induce molecular cell signaling pathways and, consequently, activate effector proteins that modulate processes related to hot flashes in menopausal women. In this review, we analyzed the literature data from the last 5 years, especially regarding genome-wide association study (GWAS) analysis, and selected molecular factors and cell signaling pathways that may potentially be related to hot flashes in women. These are the kisspeptin-GnRH pathway, adipocyte-derived hormones, aryl hydrocarbon receptor signaling, catechol estrogens and estrogen sulfotransferase, inflammatory and oxidative stress biomarkers, and glucose availability. Then, single compounds or groups of food ingredients were selected that, according to experimental data, influence the course of the discussed molecular pathways and thus can be considered as potential natural therapeutic agents to effectively reduce the troublesome symptoms of menopause in women.

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Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial

Cited by 2 publications

References 55 publications

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Menopause Hot Flashes and Molecular Mechanisms Modulated by Food-Derived Nutrients

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