Curcumin bioavailability issues and its effect on birth defects

Kumar, Akhilesh; Bind, Vimala

doi:10.15406/mojbb.2018.05.00089

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…They reported a 7.5-fold higher cell death in curcumin treated blastocysts relative to the control through the generation of ROS and Mitochondria-Dependent apoptotic signaling pathway. On the other hand, recent review on the bioavailability of curcumin and its effects on birth defects was reported by [ 51 ]. Their report described the role of curcumin as a scavenger of ROS, which was implicated by [ 50 ] as the cause of blastocyst death in mouse.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio)

Alafiatayo

Lai

Ahmad

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. Hence, this research aimed to assess the toxicity of C. longa extract on zebrafish. Using a reflux flask, methanol extract of C. longa was extracted and the identification and quantification of total flavonoids were carried out with HPLC. Twelve fertilized embryos were selected to test the embryotoxicity and teratogenicity at different concentration points. The embryos were exposed to the extract in the E3M medium while the control was only exposed to E3M and different developmental endpoints were recorded with the therapeutic index calculated using the ratio of LC50/EC50. C. longa extract was detected to be highly rich in flavonoids with catechin, epicatechin, and naringenin as the 3 most abundant with concentrations of 3,531.34, 688.70, and 523.83μg/mL, respectively. The toxicity effects were discovered to be dose-dependent at dosage above 62.50μg/mL, while, at 125.0μg/mL, mortality of embryos was observed and physical body deformities of larvae were recorded among the hatched embryos at higher concentrations. Teratogenic effect of the extract was severe at higher concentrations producing physical body deformities such as kink tail, bend trunk, and enlarged yolk sac edema. Finally, the therapeutic index (TI) values calculated were approximately the same for different concentration points tested. Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Their report described the role of curcumin as a scavenger of ROS, which was implicated by [ 50 ] as the cause of blastocyst death in mouse. The findings of [ 51 ] show that curcumin can help ameliorate the toxic effects of certain drugs with teratogenic effects prescribe during pregnancy due to their ability to scavenge ROS.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio)

Alafiatayo

Lai

Ahmad

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…They reported a 7.5-fold higher cell death in curcumin treated blastocysts relative to the control through the generation of ROS and Mitochondria-Dependent apoptotic signaling pathway. On the other hand, recent review on the bioavailability of curcumin and its effects on birth defects was reported by [52]. Their report described the role of curcumin as a scavenger of ROS, which was implicated by [51] as the cause of blastocyst death in mouse.…”

Section: Figure 5: Effects Of Curcuma Longa Extract On Zebrafish Larvmentioning

confidence: 99%

“…Their report described the role of curcumin as a scavenger of ROS, which was implicated by [51] as the cause of blastocyst death in mouse. The findings of [52] shows that curcumin can help to ameliorate the toxic effects of certain drugs with teratogenic effects prescribe during pregnancy due to their ability to scavenge ROS.…”

Section: Figure 5: Effects Of Curcuma Longa Extract On Zebrafish Larvmentioning

confidence: 99%

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

Alafiatayo

Song

Ahmad

et al. 2019

Preprint

View full text Add to dashboard Cite

Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. Hence, this research was aimed to assess the toxicity of C. longa extract on zebrafish. Using a reflux flask, methanol extract of C. longa was extracted and the identification and quantification of total flavonoids were carried out with HPLC. Twelve fertilized embryos were selected to test the embryotoxicity and teratogenicity at different concentration points. The embryos were exposed to the extract in the E3M medium while the control was only exposed to E3M and different developmental endpoints were recorded with the therapeutic index calculated using the ratio of LC50/EC50. C. longa extract was detected to be highly rich in flavonoids with catechin, epicatechin and naringenin as the 3 most abundant with concentrations of 3,531.34, 688.70 and 523.83μg/mL respectively. The toxicity effects were discovered to be dose-dependent at dosage above 62.50μg/mL, while at 125.0μg/mL, mortality of embryos was observed and physical body deformities of larvae was recorded among the hatched embryos at higher concentrations. Teratogenic effect of the extract was severe at higher concentrations producing physical body deformities such as kink tail, bend trunk, enlarged yolk sac edema. Finally, the Therapeutic Index (TI) values calculated were approximately same for different concentration points tested. Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development. Abbreviations:DMSO, dimethyl sulfoxide; HPLC, high performance liquid chromatography; OECD, organisation for economic cooperation and development; FET, fish embryo acute toxicity test; hpf, hour of post fertilization.

show abstract

Curcumin bioavailability issues and its effect on birth defects

Cited by 2 publications

References 19 publications

Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio)

Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio)

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

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