2004
DOI: 10.1038/sj.onc.1207284
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Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3

Abstract: Curcumin (Diferuloylmethane) is a major chemical component of turmeric (curcuma longa) and is used as a spice to give a specific flavor and yellow color in Asian food. Curcumin exhibits growth inhibitory effects in a broad range of tumors as well as in TPA-induced skin tumors in mice. This study was undertaken to investigate the radiosensitizing effects of curcumin in p53 mutant prostate cancer cell line PC-3. Compared to cells that were irradiated alone (SF 2 ¼ 0.635; D 0 ¼ 231 cGy), curcumin at 2 and 4 lM co… Show more

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Cited by 274 publications
(170 citation statements)
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References 45 publications
(45 reference statements)
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“…In addition to its role in prostate cancer behaviour (Andela et al, 2003), NF-kB activation is also implicated in chemo-and radioresistance. These observations are complemented by studies showing that NF-kB inhibition is a promising strategy for prostate cancer treatment, and, particularly, as a chemo-or radio-sensitisation strategy (Palayoor et al, 1999;Altuwaijri et al, 2003;Flynn et al, 2003;Kikuchi et al, 2003;Chendil et al, 2004). Clearly, inhibition of NF-kB may potentiate the antineoplastic effect of conventional chemotherapeutic agents (Sanchez-Perez et al, 2002).…”
Section: Discussionmentioning
confidence: 98%
“…In addition to its role in prostate cancer behaviour (Andela et al, 2003), NF-kB activation is also implicated in chemo-and radioresistance. These observations are complemented by studies showing that NF-kB inhibition is a promising strategy for prostate cancer treatment, and, particularly, as a chemo-or radio-sensitisation strategy (Palayoor et al, 1999;Altuwaijri et al, 2003;Flynn et al, 2003;Kikuchi et al, 2003;Chendil et al, 2004). Clearly, inhibition of NF-kB may potentiate the antineoplastic effect of conventional chemotherapeutic agents (Sanchez-Perez et al, 2002).…”
Section: Discussionmentioning
confidence: 98%
“…It is a challenging strategy to search for substances for combined use with radiation to trigger those programs of cell death that are still intact in cancer cells. Interestingly, the radiosensitizing potential of numerous botanicals and their derivatives is reported in several studies for cancer cells (Chendil et al, 2004;Park and Shin, 2004;Hara et al, 2008;Kim et al, 2008;Sandur et al, 2009). Notably, their radiosensitizing activities are found to process via several mechanisms including disturbing of cell cycle regulation, cell survival or cell death pathways.…”
Section: Introductionmentioning
confidence: 99%
“…24,25 Cell-cycle analysis was performed using propidium iodide staining followed by flow cytometric analysis as described earlier. 25 …”
Section: Methodsmentioning
confidence: 99%