Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

D'Angelo, Natália A.; Noronha, Mariana A.; Kurnik, Isabelle S.; Câmara, Mayra C.C.; Vieira, J. M. Pereira; Abrunhosa, Luı́s; Martins, Joana T.; Alves, Thaís Francine Ribeiro; Tundisi, Louise Lacalendola; Ataide, Janaína Artem; Costa, Juliana Souza Ribeiro; Jozala, Ângela Faustino; Nascimento, Laura Oliveira de; Mazzola, Priscila Gava; Chaud, Marco V.; Vicente, A. A.; Lopes, André Moreni

doi:10.1016/j.ijpharm.2021.120534

Cited by 42 publications

(23 citation statements)

References 146 publications

(139 reference statements)

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“…Studies reported that curcumin modulates cellular pathways involved in cancer pathogenesis including NF-kB, MAPK, PTEN, P53 and wnt [ 11 ]. Despite these tempting advantages of curcumin, the poor bioavailability limits its exploitation as a therapeutic compound [ 12 ]. Our team has recently formulated and characterized a nano-based encapsulated curcumin, gemini curcumin (Gemini-Cur), with significant anticancer effects on ovarian, gastric, breast and colorectal cancer [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin

Azeez

Neri²,

Feizi³

et al. 2022

Molecules

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Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The gemini nanoparticle formulation of polyphenolic curcumin significantly inhibits the viability of cancer cells. However, the molecular mechanisms and pathways underlying its toxicity in colon cancer are unclear. Here, we aimed to uncover the possible novel targets of gemini curcumin (Gemini-Cur) on colorectal cancer and related cellular pathways. After confirming the cytotoxic effect of Gemini-Cur by MTT and apoptotic assays, RNA sequencing was employed to identify differentially expressed genes (DEGs) in HCT-116 cells. On a total of 3892 DEGs (padj < 0.01), 442 genes showed a log2 FC >|2| (including 244 upregulated and 198 downregulated). Gene ontology (GO) enrichment analysis was performed. Protein–protein interaction (PPI) and gene-pathway networks were constructed by using STRING and Cytoscape. The pathway analysis showed that Gemini-Cur predominantly modulates pathways related to the cell cycle. The gene network analysis revealed five central genes, namely GADD45G, ATF3, BUB1B, CCNA2 and CDK1. Real-time PCR and Western blotting analysis confirmed the significant modulation of these genes in Gemini-Cur-treated compared to non-treated cells. In conclusion, RNA sequencing revealed novel potential targets of curcumin on cancer cells. Further studies are required to elucidate the molecular mechanism of action of Gemini-Cur regarding the modulation of the expression of hub genes.

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Section: Introductionmentioning

confidence: 99%

Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin

Azeez

Neri²,

Feizi³

et al. 2022

Molecules

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“…Curcumin encapsulation in food-grade biopolymers or colloidal delivery systems can overcome the challenges associated with its application [ 77 , 78 ]. Encapsulation technology can increase the solubility and bioavailability of curcumin ( Figure 3 ), while protecting this compound against hydrolysis, enzymatic action, and conjugation inactivation, among others [ 79 , 80 ].…”

Section: Encapsulation Of Curcumin For Application As a Bioactive Agentmentioning

confidence: 99%

Edible Bioactive Film with Curcumin: A Potential “Functional” Packaging?

Filho

Egea

2022

IJMS

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Edible packaging has been developed as a biodegradable and non-toxic alternative to traditional petroleum-based food packaging. Biopolymeric edible films, in addition to their passive protective function, may also play a bioactive role as vehicles for bioactive compounds of importance to human health. In recent years, a new generation of edible food packaging has been developed to incorporate ingredients with functional potential that have beneficial effects on consumer health. Curcumin, a bioactive compound widely used as a natural dye obtained from turmeric rhizomes (Curcuma longa L.), has a broad spectrum of beneficial properties for human health, such as anti-inflammatory, anti-hypertensive, antioxidant, anti-cancer, and other activities. To demonstrate these properties, curcumin has been explored as a bioactive agent for the development of bioactive packaging, which can be referred to as functional packaging and used in food. The aim of this review was to describe the current and potential research on the development of functional-edible-films incorporating curcumin for applications such as food packaging.

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“…Different types of synthetic nanocarriers have been developed to deliver curcumin: lipid-based curcumin formulations (liposomes, solid-liquid nanoparticles, nanostructured lipid carriers) and polymeric-based curcumin formulations (micelles, polymeric nanoparticles, polymeric conjugates) (for review see [ 96 , 107 ]).…”

Section: New Nanodelivery Strategies To Increase Pharmacological Activities Of Curcuminmentioning

confidence: 99%

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

et al. 2021

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The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed.

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Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

Cited by 42 publications

References 146 publications

Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin

Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin

Edible Bioactive Film with Curcumin: A Potential “Functional” Packaging?

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

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