Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic palmitic acid-grafted-quaternized chitosan with enhanced cytotoxic, antimicrobial and antioxidant properties

Xie, Yinzhuo; Gong, Xiaochen; Jin, Zheng; Xu, Wei; Zhao, Kai

doi:10.1016/j.ijbiomac.2022.10.064

Cited by 24 publications

(15 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the drug release of the CUR@PA‐N‐2‐HACC‐Cys NPs was assessed by simulating digestive tract conditions in vitro. In our previous study, we have explored in vitro release of the CUR@PA‐N‐2‐HACC NPs and it was reported that the CUR@PA‐N‐2‐HACC NPs exhibited a slow‐release effect 49 . In the present study, we also investigated in vitro release of the CUR@PA‐N‐2‐HACC‐Cys NPs (Figure 1d) and the results showed that the release rate of the CUR@PA‐N‐2‐HACC‐Cys NPs was slow, and the cumulative release amount was about 17% in SGF.…”

Section: Resultsmentioning

confidence: 99%

“…In the present study, we also investigated in vitro release of the CUR@PA‐N‐2‐HACC‐Cys NPs (Figure 1d) and the results showed that the release rate of the CUR@PA‐N‐2‐HACC‐Cys NPs was slow, and the cumulative release amount was about 17% in SGF. The reason might be due to the presence of hydrophobic PA core, intermolecular hydrogen bonds, ionization of ammonium groups, and the formation of disulfide bonds in or outside the polymers 49 . In addition, when the CUR@PA‐N‐2‐HACC‐Cys NPs were transferred to SIF, the release of CUR was triggered, and the CUR@PA‐N‐2‐HACC‐Cys NPs presented a sustained and controlled release behavior up to 24 h, increasing from 18% to almost 52% in the final of the experiment, which demonstrated a pH‐response behavior.…”

Section: Resultsmentioning

confidence: 99%

“…The results suggested that CUR could be released from CUR@PA‐N‐2‐HACC‐Cys NPs in response to the intestinal environment. The pH‐response release manner could be explained since most of the ammonium groups in the N‐2‐HACC units were neutralized at intestinal pH, leading to the destruction of the hydrophilic shell of the nanomicelles, which might allow the CUR release 49 . Therefore, the sustained and controlled release of the CUR@PA‐N‐2‐HACC‐Cys NPs could contribute to the absorption of CUR in the intestine, thus improving its bioavailability.…”

Section: Resultsmentioning

confidence: 99%

“…The PA‐N‐2‐HACC was synthesized according to our previously published protocol 49 . The PA‐N‐2‐HACC‐Cys was synthesized via esterification of hydroxyl groups on PA‐N‐2‐HACC and the carboxyl group of Cys (Figure 8a).…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Palmitic acid‐ and cysteine‐functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug

Xie

Jin

et al. 2023

Bioengineering & Transla Med

Self Cite

View full text Add to dashboard Cite

Nanoparticles (NPs) used for oral administration have greatly improved drug bioavailability and therapeutic efficacy. Nevertheless, NPs are limited by biological barriers, such as gastrointestinal degradation, mucus barrier, and epithelial barrier. To solve these problems, we developed the PA‐N‐2‐HACC‐Cys NPs loaded with anti‐inflammatory hydrophobic drug curcumin (CUR) (CUR@PA‐N‐2‐HACC‐Cys NPs) by self‐assembled amphiphilic polymer, composed of the N‐2‐Hydroxypropyl trimethyl ammonium chloride chitosan (N‐2‐HACC), hydrophobic palmitic acid (PA), and cysteine (Cys). After oral administration, the CUR@PA‐N‐2‐HACC‐Cys NPs had good stability and sustained release under gastrointestinal conditions, followed by adhering to the intestine to achieve drug mucosal delivery. Additionally, the NPs could penetrate mucus and epithelial barriers to promote cellular uptake. The CUR@PA‐N‐2‐HACC‐Cys NPs could open tight junctions between cells for transepithelial transport while striking a balance between mucus interaction and diffusion through mucus. Notably, the CUR@PA‐N‐2‐HACC‐Cys NPs improved the oral bioavailability of CUR, which remarkably relieved colitis symptoms and promoted mucosal epithelial repair. Our findings proved that the CUR@PA‐N‐2‐HACC‐Cys NPs had excellent biocompatibility, could overcome mucus and epithelial barriers, and had significant application prospects for oral delivery of the hydrophobic drugs.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Palmitic acid‐ and cysteine‐functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug

Xie

Jin

et al. 2023

Bioengineering & Transla Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…And its possible explantation is that external application of curcumin can induce the allergic reaction of skin. Oral administration of curcumin might cause gastrointestinal pain, nausea, vomit and liver poisoning ( Xie et al, 2022 ). Otherwise, the overdose of curcumin can aggravate the cholecystolithiasis in that curcumin is mainly metabolized by the liver, so that the excessive administration of curcumin can induce liver dysfunction.…”

Section: The Side Effect Of Curcumin Usage and The Suggested Administ...mentioning

confidence: 99%

Role of curcumin in ischemia and reperfusion injury

Zhang

2023

Front. Pharmacol.

View full text Add to dashboard Cite

Ischemia-reperfusion injury (IRI) is an inevitable pathological process after organic transplantations. Although traditional treatments restore the blood supply of ischemic organs, the damage caused by IRI is always ignored. Therefore, the ideal and effective therapeutic strategy to mitigate IRI is warrented. Curcumin is a type of polyphenols, processing such properties as anti-oxidative stress, anti-inflammation and anti-apoptosis. However, although many researches have been confirmed that curcumin can exert great effects on the mitigation of IRI, there are still some controversies about its underlying mechanisms among these researches. Thus, this review is to summarize the protective role of curcumin against IRI as well as the controversies of current researches, so as to clarify its underlying mechanisms clearly and provide clinicians a novel idea of the therapy for IRI.

show abstract

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Aanniz,

El Omari,

Elouafy

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their chemical, physical, and biological properties. It is well known that essential oils (EOs) provide a valuable alternative for food preservation, as they help reducing the deterioration of foodstuffs as well as the proliferation of pathogens. Nevertheless, EOs are highly volatile and lipophilic, rendering them insoluble in aqueous systems. In addition, their secondary metabolites are extremely susceptible to environmental factors such as humidity, temperature, light, and oxygen. Therefore, encapsulation of EOs is an innovative option not only for preserving these substances but also for promoting their stability, controlling their release, and optimizing their efficiency and bioavailability. In this sense, this review aimed to describe current techniques and approaches used to incorporate natural hydrophobic compounds, covering EOs. It also examines whether encapsulation technology can be used efficiently in drug discovery and development. Studies have shown that microencapsulation, the use of nanoparticle, and liposomal are the most effective techniques for encapsulating EOs. Other encapsulation systems included spray drying, coacervation, and emulsification.

show abstract

Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic palmitic acid-grafted-quaternized chitosan with enhanced cytotoxic, antimicrobial and antioxidant properties

Cited by 24 publications

References 72 publications

Palmitic acid‐ and cysteine‐functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug

Palmitic acid‐ and cysteine‐functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug

Role of curcumin in ischemia and reperfusion injury

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Contact Info

Product

Resources

About