Curcumin for malaria therapy

Reddy, Raju C.; Vatsala, Palakkodu G.; Keshamouni, Venkateshwar G.; Padmanaban, Govindarajan; Rangarajan, Pundi N.

doi:10.1016/j.bbrc.2004.11.051

Cited by 334 publications

(224 citation statements)

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“…It has been shown that curcumin have a wide spectrum of biological activities. 13 The extracts of turmeric rhizome has recently been used as an insect repellent ,anti-bacterial, 14 antidiabetic, 15 antioxidant, 16,17 anti-inflammatory, 18,19 anticancer, 20 antiallergic, 21 antiprotozoal 22 and wound healing activity. 23 The main objectives of the present study were to evaluate and compare the antimicrobial activity of the extracts from rhizome and leaf of Curcuma longa Linn against various bacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

Comparative Antimicrobial Study of Ethanolic Extract of Leaf and Rhizome of Curcuma longa Linn

Singh¹,

Gupta²,

Rathore³

2017

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Introduction: Curcuma longa L., botanically related to ginger belongs to the Zingiberaceae family. It is extensively used in Ayurveda, Unani and Siddha medicine as a home remedy for various diseases. Aim: The present study is to compare the antimicrobial activity of the ethanolic extracts from rhizome and leaf of Curcuma longa Linn. Method: In vitro disc diffusion method and serial dilution method has been used to determine the antimicrobial potency against various bacterial pathogens such as Klebsiella pneumoniae Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis by comparing the zone of inhibition shown by both the test extracts at different concentration (25 mg/ml, 50 mg/ml, 100 mg/ml, 150 mg/ml, 200 mg/ml, 250 mg/ml, 300 mg/ml) and there MIC value has been evaluated. Ethanol and Ampicillin were used as negative and positive control for the study. Result: The leaf and rhizome extract showed maximum zone of inhibition at 300 mg/ml concentration, which was about 7.6 mm and 8 mm on the bacterial strain Pseudomonas aeruginosa and least effectiveness for other bacterial strain such as Staphylococcus aureus and Bacillus subtilis. The recorded MIC value was at 6.25 mg/ml which showed 3.991% inhibition for rhizome extract and 3.129% inhibition for leaf extract. Conclusion: The rhizome extract was found to be more potent antimicrobial agent than the leaf extract and can be used in future studies.

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Section: Introductionmentioning

confidence: 99%

Comparative Antimicrobial Study of Ethanolic Extract of Leaf and Rhizome of Curcuma longa Linn

Singh¹,

Gupta²,

Rathore³

2017

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“…Limited number of st udies reported the anti -parasitic activit y of curcumi n. It was r eported t hat c urcumi n show ed its c yt ot oxi cit y ac tion agains t Trypanosom es that c aus e Afric an sleeping sickness (N os e et al ., 1998). Additionall y, oral administrati on of c urc umin to mice inf ec ted with m alaria parasi te ( Plasm odium berghei ) reduced blood parasitemi a b y 80% -90% and enhanc ed t heir surviv al signi ficantl y (Reddy et al, 2005). Traditionall y curc umin is us ed as a spice in hum an diet and is easil y obtai ned i n many s hops.…”

Section: Issn: 2090 -0511mentioning

confidence: 99%

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

Mira¹

2017

Egypt. J. Exp. Biol. (Zoo.)

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N ab i l a Mous a Mi r aT he potential ameli orativ e effect of curcu min i n Sc histoso ma mansoni infecte d mic e: an ultrastru ctural study on the testes ABSTRACT:This inves tigation has been designed t o eval uate the antibilharzial ef ficienc y and th e possible amelior ativ e r ole of c urc umin on adult m ale Swiss albino mic e tes tes . T hirt y anim als were us ed in t his experiment , divided equall y into 3 groups: group 1, c ontr ol group; group 2, inf ect ed with S. mans oni, and group 3, infec ted mice treat ed with c urcumin.Ultrastruc tur e examinati on was perform ed on the tes tes usi ng transmissi on electron microscop y (TE M). R es ults i ndicat ed that the test es in t he inf ec ted group s howed thick eni ng and irregul arit y i n t he s urrounding basal l amina, c yt oplasmic vac uolat i on of atrophi ed Sert oli c ells, shrinkage and p yk notic nucl ei of spermat ogonia , as w ell as primar y spermat oc yt es, especiall y i n fr ont of t he s ex vesicles . Furt hermore, S ertoli c ells c ont ai ned various f orms of mitoc hondrial d egeneration and wide int ercell ul ar sp aces of adherent juncti on am ong the S ertoli, as w ell as spermat ogenic c ells. B esides, m ost of sperms were mark edly aff ect ed. Supplement ati on of curcumi n minimized the degener ativ e chang es in t he nucl ear envel ope and sex v esicles of the primar y spermat oc yte nucl ei besides narrowi ng the adherent juncti on among S ertoli cells and germ c ells. In c onclusi on, c urcumi n proved to hav e a pot ential rol e i n minimizing the deleteri ous ef fec t of S. m ansoni in t est es of t he infec ted mic e. KEY WORDS:Schis tos oma mans oni, Swiss albino mice, test es, curc umin, ultr astr uct ure

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“…Throughout the study, the animals were provided with soy-free and filtered drinking water. For the acute and sub-acute-toxicity study, the CU complexes equivalent to 2000 mg/kg BW of CU and 100 mg/kg BW of CU, respectively, were administered (Reddy et al, 2005;Camacho-Barquero et al, 2007).…”

Section: Cytotoxicity Studies By Mtt Assaymentioning

confidence: 99%

Development, characterization and toxicological evaluations of phospholipids complexes of curcumin for effective drug delivery in cancer chemotherapy

et al. 2014

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The purpose of this study was to prepare and characterize the complexes between curcumin (CU) phosphatidylcholine (PC) and hydrogenated soya phosphatidylcholine (HSPC) and to evaluate their anticancer activity. These CU-PC and CU-HSPC complexes (CU-PC-C and CU-HSPC-C) were evaluated for various physical parameters like Fourier transform infrared spectroscopy, melting point, solubility, scanning electron microscopy and the in vitro drug release study. These data confirmed the formation of phospholipids complexes. The in vitro hemolysis study showed that the complex was non-hemolytic. The anti-cancer potential of the complexes was demonstrated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay in MCF-7 cell line. This increase may be due to the amphiphilic nature of the complexes, which significantly enhances the water and lipid solubility of the CU. Unlike the free CU (which showed a total of only 90% drug release at the end of 8 h), complex showed around 40-60% release at the end of 8 h in dissolution studies. It showed that (when given in equimolar doses) complexes have significantly decreased the amount of CU available for absorption as compared with CU-free drug. Both CU-PC-C and CU-HSPC-C were found to be non-toxic at the dose equivalent to 2000 mg/kg of body weight of CU in the toxicity study. Acute and subacute toxicity studies confirmed the oral safety of the formulation. A series of genotoxicity studies was conducted, which revealed the non-genotoxicity potential of the developed complexes. Thus, it can be concluded that the phospholipid complexes of CU may be a promising candidate in cancer therapy.

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Curcumin for malaria therapy

Cited by 334 publications

References 10 publications

Comparative Antimicrobial Study of Ethanolic Extract of Leaf and Rhizome of Curcuma longa Linn

Comparative Antimicrobial Study of Ethanolic Extract of Leaf and Rhizome of Curcuma longa Linn

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

Development, characterization and toxicological evaluations of phospholipids complexes of curcumin for effective drug delivery in cancer chemotherapy

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