Curcumin-Hydroxypropyl-β-Cyclodextrin Inclusion Complex Preparation Methods: Effect of Common Solvent Evaporation, Freeze Drying, and pH Shift on Solubility and Stability of Curcumin

Abstract

Purpose: To evaluate the effect of the preparation method on the inclusion complex of curcumin and hydroxypropyl-β-cyclodextrin (HP-β -CD

Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery

“…The chemical interaction for the inclusion complex between cyclodextrin and curcumin may include a van der Waals interaction, hydrogen bonding, and hydrophobic interaction [33]. This implies that common solvent evaporation could produce a curcumin-HPBCD inclusion complex, which complies with a previous study [34]. The DSC thermograms of the composite membrane showed a small peak in accordance with curcumin and a small broad peak in accordance with the bacterially derived cellulose and the HPBCD, but a peak in accordance with piperine was not observed.…”

“…The impact of pH, temperature, and molecular environment on the stability of curcumin is generally known [35]. One way to increase the stability of curcumin is to form an inclusion complex with cyclodextrin [34]. The high stability of curcumin in the composite membrane could be from the inclusion complex with HPBCD within the composite membrane, together with the storage condition as in normal temperature and protected from light.…”

Selection and optimization of nano-formulation of P-glycoprotein inhibitor for reversal of doxorubicin resistance in COLO205 cells

“…These complexes have indeed improved the solubility of Cur and resultantly improved its activity in various cancers such as ovarian cancer, squamous cell carcinoma and other inflammatory conditions. However, frustratingly the EE of complexed form barely varies between 1 and 5% at different experimental conditions . There are two possible reasons for lower Cur loading into HP‐β‐CD.…”

“…However, frustratingly the EE of complexed form barely varies between 1 and 5% at different experimental conditions. [33][34][35] There are two possible reasons for lower Cur loading into HP-b-CD. Firstly, the equilibrium between encapsulated and un-encapsulated state is facilitated for the later.…”

Validation of a New RP-HPLC Method for Determination of Hydrocortisone Acetate Complexed with HPβCD in a Oral Liquid Pharmaceutical Preparation

“…The HA show poorly water solubility and instability due to suffer hydrolysis [6]. One method to overcome this problem is the use of cyclodextrins (CDs), which have been extensively studied [7].…”