Curcumin in Combination With Triple Therapy Regimes Ameliorates Oxidative Stress and Histopathologic Changes in Chronic Gastritis-Associated Helicobacter Pylori Infection

Judaki, Arezu; Rahmani, Asghar; Feizi, Jalil; Asadollahi, Khairollah; Ahmadi, Mohammad Reza

doi:10.1590/s0004-2803.201700000-18

Cited by 55 publications

(46 citation statements)

References 28 publications

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“…Curcumin can also inhibit the production of many proinflammatory cytokines by inhibiting the activity of inducible NOS, which can alleviate the inflammatory reaction of mice with multidrug resistance gene deficiency, alleviate the development of colitis induced by sodium dextran sulfate, and inhibit the production of many proinflammatory cytokines [6] . NO free radicals and superoxide anions were effectively eliminated, and oxidative stress and acute gastric injury were alleviated [7] . The results of this study are similar to those of the above studies.In conclusion, curcumin may inhibit NO production to improve gastric emptying by inhibiting the activity of inducible NOS in gastric tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin on Gastric Emptying Induced by L-arginine in Mice

Liu¹,

Yu²,

Wang³

et al. 2018

ijSciences

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Objective To investigate the mechanism of curcumin administration on gastric emptying induced by L-arginine in mice. Methods Kunming male mice were divided into control group, curcumin group, L-arginine group and curcumin L-arginine combination group.There were nine mice in each group. The curcumin group and curcumin L-arginine combination group were treated with curcumin solution once a day for 15 days. From the 11th day onwards, the L-arginine group and the curcumin L-arginine combination group were given intragastric administration of L-arginine once a day for 5 days. The other groups were given solvent solution as control. The gastric emptying rate, NO content and nitric oxide synthase (NOS) activity in gastric tissue were measured after fasting for 24 hours. Results There was no significant difference between single curcumin group and the control group (P>0.05). But the gastric emptying rate in L-arginine group was significantly lower (P<0.01), the NO and the activity of NOS in stomach tissue was significantly higher (P<0.01) than that in the control group. The gastric emptying rate in curcumin L-arginine combination group was significantly higher (P<0.01), the NO content and the activity of NOS in gastric tissue was significantly higher (P<0.01) than that in L-arginine group. Conclusion curcumin can inhibit the production of no by inhibiting the NOS activity of gastric tissue, and then improve the gastric emptying of mice. Keywords: Curcumin, L-arginine, Gastric EmptyingCurcumin is a phenolic plant of the family Curcumae extracted from the rhizome of turmeric. It has many biological activities, such as cardiovascular protection and anti-tumor [1 ， 2] . Curcumin could significantly improve the gastrointestinal peristalsis induced by L-arginine [3] . However, the specific mechanism of curcumin was not clear.The L-arginine was the precursor of NO. NO as a non-cholinergic non-adrenergic neurotransmitter can be produced under the action of nitric oxide synthase (NOS) in vivo and plays an inhibitory role in gastrointestinal motility. The effect of curcumin on the production of NO was investigated by detecting the content of NO and the activity of NOS in gastric tissue of mice. Methods Animals and treatmentThirty-six healthy male Kunming mice were randomly divided into control group, curcumin group, L-arginine group and curcumin L-arginine combination group. Curcumin group and curcumin L-arginine combination group was given curcumin suspension 200mg/kg for 15days. The L-arginine group was treated with L-arginine on the 11th day of gavage.The other groups were given the same amount of solvent solution as the control. Gastric emptying rateAt the end of the experiment, the mice in each group fasted for 24 hours and drank freely. The mice were perfused with 0.8ml half fluid suspension of 80% mass fraction of Arabinol, then the mice were killed after 20 min. The gastric cardia and pylorus were ligated by caesarean section, and the total weight of stomach was removed. The appetizers were cut along the great ...

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Section: Discussionmentioning

confidence: 99%

Effect of Curcumin on Gastric Emptying Induced by L-arginine in Mice

Liu¹,

Yu²,

Wang³

et al. 2018

ijSciences

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“…Combining of phytomedicine with standard medicine may offer effective H. pylori treatment. Judaki et al reported that addition of a turmeric extract (curcumin) to the standard triple therapy significantly increased the eradication rate of H. pylori and decreased oxidative damage to DNA (Judaki et al 2017). Treatment with curcumin reduced the number of bacteria colonizing gastric mucosa and reduced the activity of lipid peroxidases and urease in H. pylori infected mice (Kwiecien et al 2019).…”

Section: Phytomedicine In the Treatment Of H Pylorimentioning

confidence: 99%

Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets

Roszczenko-Jasińska

Wojtyś

Jagusztyn-Krynicka

2020

Appl Microbiol Biotechnol

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Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen. The prevalence of H. pylori infections varies worldwide. The H. pylori genotype, host gene polymorphisms, and environmental factors determine the type of induced disease. Currently, the most common therapy to treat H. pylori is the first line clarithromycin–based triple therapy or a quadruple therapy replacing clarithromycin with new antibiotics. Despite the enormous recent effort to introduce new therapeutic regimens to combat this pathogen, treatment for H. pylori still fails in more than 20% of patients, mainly due to the increased prevalence of antibiotic resistant strains. In this review we present recent progress aimed at designing new anti-H. pylori strategies to combat this pathogen. Some novel therapeutic regimens will potentially be used as an extra constituent of antibiotic therapy, and others may replace current antibiotic treatments. Key points • Attempts to improve eradication rate of H. pylori infection. • Searching for new drug targets in anti-Helicobacter therapies.

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“…A study from Africa suggests that the methanol extract of Bryophyllum pinnatum , a plant known for its antioxidant properties, could inhibit H. pylori growth, and may also act as an antioxidant to protect gastric mucosa against reactive oxygen species . A study from Iran demonstrated reduced endoscopic scores of inflammation and increased H. pylori eradication rates with the addition of curcumin (a turmeric extract) to standard triple therapy . An Egyptian group evaluated eradication rates with nitazoxanide, an anti‐infective drug with demonstrated activity against protozoa and anaerobic bacteria but also H. pylori .…”

Section: Novel Therapiesmentioning

confidence: 99%

Treatment of Helicobacter pylori infection in 2018

et al. 2018

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Treatment options for the eradication of Helicobacter pylori continue to evolve. There have been many guidelines for H. pylori treatment published, which may lead to some confusion. However, most are in agreement with the most recent iteration of the Maastricht treatment guidelines. Triple therapy is still the most frequently used treatment, especially in areas of low clarithromycin resistance. Its best results are achieved when taken for a minimum of 10 days and with high-dose acid suppression. Quadruple therapy is gaining in popularity particularly in areas with increasing resistance to standard triple therapy. Whether three antibiotics, or bismuth and two antibiotics are used, excellent eradication rates are achieved, albeit with increased side effects. Levofloxacin second-line therapy is widely used; however bismuth, when available, is an increasingly successful option. Sequential therapy is challenging in terms of compliance and is no longer recommended. This past year witnessed a notable increase in the number of studies based on antimicrobial susceptibility testing and tailored eradication therapy, reflecting the role of culture-guided treatment, which may well represent the future of H. pylori treatment and prevent the inappropriate use of antibiotics.

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Curcumin in Combination With Triple Therapy Regimes Ameliorates Oxidative Stress and Histopathologic Changes in Chronic Gastritis-Associated Helicobacter Pylori Infection

Cited by 55 publications

References 28 publications

Effect of Curcumin on Gastric Emptying Induced by L-arginine in Mice

Effect of Curcumin on Gastric Emptying Induced by L-arginine in Mice

Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets

Treatment of Helicobacter pylori infection in 2018

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