Curcumin incorporated polyurethane urea elastomers with tunable thermo-mechanical properties

Shah, Sayyed Asim Ali; Imran, Muhammad; Lian, Qingsong; Shehzad, Farooq Khurum; Athir, Naveed; Zhang, Junying; Cheng, Jue

doi:10.1016/j.reactfunctpolym.2018.05.005

Cited by 29 publications

(19 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, the rise in the vapor barrier properties of PBAT films with the incorporation of curcumin may be due to an increase in the density of the film or a decrease in free volume after mixing with curcumin ( Figure 1 ). It has been stated that the blending of curcumin to PLA-based film reduced the WVP, whereas the addition of GSE to PLA/PBAT composite film reduced the water vapor barrier properties [ 20 , 47 ]. On the contrary, the addition of impermeable nanoparticles such as silver nanoparticles and graphene oxide was supposed to form a tortuous path of water vapor diffusion in the PBAT film to reduce the WVP [ 17 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The increase in the WCA of PBAT-based films most probably because of the hydrophobic nature of curcumin [ 33 ]. The addition of curcumin to PLA-based film also pointedly enhanced the surface hydrophobicity of the film [ 47 ]. Additionally, the improved surface water-resistant activity by incorporating curcumin was described in previous reports [ 31 , 34 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Curcumin Incorporated Poly(Butylene Adipate-co-Terephthalate) Film with Improved Water Vapor Barrier and Antioxidant Properties

Roy

Rhim

2020

Materials

View full text Add to dashboard Cite

Curcumin incorporated poly(butylene adipate-co-terephthalate) (PBAT) based film was fabricated. Curcumin has uniformly distributed in the PBAT matrix to form a bright yellow PBAT/curcumin film. The PBAT/curcumin film has slightly reduced tensile strength and flexibility than the neat PBAT film, while the thermal stability of the film has not changed significantly. The blending of curcumin significantly decreased the water vapor permeability of the PBAT film. Additionally, the PBAT/curcumin film showed potent antioxidant activity with some antimicrobial activity. The PBAT/curcumin films with improved water vapor barrier and additional functions can be used for active packaging applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Curcumin Incorporated Poly(Butylene Adipate-co-Terephthalate) Film with Improved Water Vapor Barrier and Antioxidant Properties

Roy

Rhim

2020

Materials

View full text Add to dashboard Cite

show abstract

“…Spectral peaks characteristic of PUs can be seen in the spectra. Thus, around 3330 cm −1 , the characteristic bands for the stretching vibrations of the −N–H bonds are observed [40] from which it can be inferred that they correspond to the urethane bonds present in the matrices. Near 2923 cm −1 , the stretching peak of the methyl group can be observed, and at around 2855 cm −1 , the symmetric stretching of the C–H bond is present.…”

Section: Resultsmentioning

confidence: 99%

Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Applications

et al. 2019

View full text Add to dashboard Cite

Polyurethanes are widely used in the development of medical devices due to their biocompatibility, degradability, non-toxicity and chemical versatility. Polyurethanes were obtained from polyols derived from castor oil, and isophorone diisocyanate, with the incorporation of polycaprolactone-diol (15% w/w) and chitosan (3% w/w). The objective of this research was to evaluate the effect of the type of polyol and the incorporation of polycaprolactone-diol and chitosan on the mechanical and biological properties of the polyurethanes to identify the optimal ones for applications such as wound dressings or tissue engineering. Polyurethanes were characterized by stress-strain, contact angle by sessile drop method, thermogravimetric analysis, differential scanning calorimetry, water uptake and in vitro degradation by enzymatic processes. In vitro biological properties were evaluated by a 24 h cytotoxicity test using the colorimetric assay MTT and the LIVE/DEAD kit with cell line L-929 (mouse embryonic fibroblasts). In vitro evaluation of the possible inflammatory effect of polyurethane-based materials was evaluated by means of the expression of anti-inflammatory and proinflammatory cytokines expressed in a cellular model such as THP-1 cells by means of the MILLIPLEX® MAP kit. The modification of polyols derived from castor oil increases the mechanical properties of interest for a wide range of applications. The polyurethanes evaluated did not generate a cytotoxic effect on the evaluated cell line. The assessed polyurethanes are suggested as possible candidate biomaterials for wound dressings due to their improved mechanical properties and biocompatibility.

show abstract

“…The mechanical properties of all the designed elastomers were elastic with elongation at break ranging between 213.2% and 925.38%, Young’s moduli ranging between 2.18 and 23.33 MPa, and tensile strength ranging between 7.34 and 19.08 MPa. The in vitro antimicrobial analysis of curcumin-loaded elastomers exhibited superior antibacterial effects against S. aureus and E. coli [ 149 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

View full text Add to dashboard Cite

Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

show abstract

Curcumin incorporated polyurethane urea elastomers with tunable thermo-mechanical properties

Cited by 29 publications

References 36 publications

Curcumin Incorporated Poly(Butylene Adipate-co-Terephthalate) Film with Improved Water Vapor Barrier and Antioxidant Properties

Curcumin Incorporated Poly(Butylene Adipate-co-Terephthalate) Film with Improved Water Vapor Barrier and Antioxidant Properties

Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Contact Info

Product

Resources

About