Curcumin loaded mesoporous silica nanoparticles: assessment of bioavailability and cardioprotective effect

Yadav, Yogesh Chand; Pattnaik, Satyanarayan; Swain, Kalpana

doi:10.1080/03639045.2019.1672717

Cited by 48 publications

(53 citation statements)

References 25 publications

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“…Notably, cardioprotective activity of curcumin against DOX toxicity can be improved using nanoparticles. Mesoporous silica nanoparticles (MSNs) significantly promote bioavailability of curcumin that is beneficial for decreasing oxidative damage and reinforcing the antioxidant defense system by enhancing activities of SOD, CAT and GSH [166]. According to the fact that poor bioavailability of curcumin is a barrier for its therapeutic effects, loading curcumin on nanoparticles remarkably promotes its bioavailability that is of importance for preventing DOX-mediated cardiotoxicity [167].…”

Section: Impact On Adverse Effectsmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

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Section: Impact On Adverse Effectsmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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“…In recent years, curcumin has attracted considerable interest in the biological research field due to its nontoxic properties. Curcumin is pharmacologically safe and has multifunctional activity in nature and has a variety of therapeutic properties including antioxidant, antifungal, antibacterial, antiseptic and antitumor activities (Yadav et al 2019). There are many metal oxide nanoparticles are using in biomedical applications like ZnO, TiO 2 , SiO 2 etc.… Silica Np's has been applied in many fields, such as catalysis, theranostics, and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Investigation of hemolysis and antibacterial analysis of curcumin-loaded mesoporous SiO2 nanoparticles

2021

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In this present investigation, synthesis and characterization of mesoporous SiO 2 was prepared and the curcumin drug was loaded into the nanoparticles. The haemolytic study and antibacterial activity were investigated. The work is focused on the synthesis of silica by sol-gel methods from precursor of silica tetraethyl orthosilicate (TEOS), NaOH, pore generating agent cetyltrimethylammonium bromide (CTAB). The morphology analysis of the particles was carried out using fieldemission scanning electron microscopy techniques (FESEM), Silica dioxide were confirmed by XRD and FTIR analysis. The Mesoporous analysis, surface area, pore size and pore volumes N2 adsorption/desorption are carried out by BET analysis.

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“…We also investigated the effect of DBL on the expression of proinflammatory cytokines, as many cardioprotective compounds inhibit inflammatory cytokines [42,43]. Elevated levels of the proinflammatory cytokines TGF-β, TNF-α, and IL-6 mRNA were also observed in SAMP8 mice.…”

Section: Discussionmentioning

confidence: 99%

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice

Giridharan

Karupppagounder

Arumugam

et al. 2020

Cells

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Aging is a predominant risk factor for the development and progression of cardiovascular complications. Physiologically and anatomically, the heart undergoes numerous changes that result in poor cardiac function in the elderly population. Recently, several studies have provided promising results, confirming the ability of the senescence-accelerated mouse-prone 8 (SAMP8) model to accurately model age-related cardiovascular alterations. In this study, using a murine model of senescence, SAMP8, we aimed to investigate the effect of 3,4-dihydroxybenzalacetone (DBL), a catechol-containing phenylpropanoid derivative isolated from Inonotus obliquus (Chaga), on cardiac aging. DBL was administered at the doses of 10 mg/kg and 20 mg/kg by oral gavage to SAMP8 mice to examine aging-mediated cardiac changes, such as oxidative DNA damage, oxygen radical antioxidant capacity (ORAC) value, fibrosis, inflammation, and apoptosis. The treatment with DBL at both doses significantly reduced aging-mediated oxidative DNA damage, and simultaneously increased the ORAC value in the SAMP8 assay. Cardiac fibrosis was assessed with Azan-Mallory staining, and the number of cardiac remodeling markers was found to be significantly reduced after the treatment with DBL. We also observed a decrease in cardiomyocyte apoptosis as measured by the terminal transferase-mediated dUTP nick end labeling (TUNEL) staining method and the caspase-3 levels in SAMP8 mice compared with senescence-resistant control (SAMR1) mice. The findings from this study suggest that DBL has a potentially beneficial effect on aging-mediated myocardial alterations. Further studies are warranted to confirm the promising potential of this catechol compound against aging-associated myocardial dysfunction.

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Curcumin loaded mesoporous silica nanoparticles: assessment of bioavailability and cardioprotective effect

Cited by 48 publications

References 25 publications

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Investigation of hemolysis and antibacterial analysis of curcumin-loaded mesoporous SiO2 nanoparticles

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice

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