Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract

Chen, Xi; Wang, Di; Guo, Xuejun; Li, Xiaoming; Ye, Wenjing; Yang, Qi; Gu, Wen

doi:10.3389/fphar.2022.824652

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…This effect was significantly higher with curcumin‐loaded mPEG‐PLGA nanoparticles. Both curcumin and its nanoparticle at high doses recovered the decrease in HDAC2 level induced by 10% CSE exposure (Chen et al, 2022).…”

Section: Protective Role Of Curcumin Against Damaging Effects Of Ciga...mentioning

confidence: 99%

The protective effects of curcumin against cigarette smoke‐induced toxicity: A comprehensive review

Fanoudi,

Alavi,

Mehri

et al. 2023

Phytotherapy Research

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Cigarette smoking (CS) is a crucial modifiable risk of developing several human diseases and cancers. It causes lung, bladder, breast, and esophageal cancers, respiratory disorders, as well as cardiovascular and metabolic diseases. Because of these adverse health effects, continual efforts to decrease the prevalence and toxicity of CS are imperative. Until the past decades, the impacts of natural compounds have been under investigation on the harmful effects of CS. Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant that belongs to the Zingiberaceae family, is the main source of curcumin. This review is an attempt to find out the current knowledge on CS's harmful effects and protective potential of curcumin in the pulmonary, liver, brain, gastrointestinal, and testis organs. According to the present review, simultaneous consumption of curcumin and CS can attenuate CS toxicities including chronic obstructive pulmonary disease, gastrointestinal toxicity, metabolic diseases, testis injury, and neurotoxicity. Moreover, curcumin suppresses carcinogenesis in the skin, liver, lungs, breast, colon, and stomach. Curcumin mediates these protective effects through antioxidant, anti‐inflammatory, anti‐apoptotic, and anti‐carcinogenicity properties.

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Section: Protective Role Of Curcumin Against Damaging Effects Of Ciga...mentioning

confidence: 99%

The protective effects of curcumin against cigarette smoke‐induced toxicity: A comprehensive review

Fanoudi,

Alavi,

Mehri

et al. 2023

Phytotherapy Research

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“…Thus, the nanoformulation based on PLGA NPs to CUR delivery has proven to increase its absorption in the organism and protect it from degrading agents, in addition to allowing the design of versatile DDS for different applications. In this sense, formulations comprising CUR-loaded PLGA NPs have recently promoted: ( i ) increase in bone regeneration in implanted areas in type-2 diabetic mice; ( ii ) decrease in the Aβ plaques aggregation, which is directly associated to inflammatory processes of the Alzheimer’s disease; ( iii ) anti-COVID-19 activities; ( iv ) anticancer activities against some of the most dangerous types of tumors, such as liver, brain, and chemoresistant breast cancer; − ( v ) anti-atherosclerotic activity; and ( vi ) reversal of corticosteroid resistance in smokers …”

Section: Introductionmentioning

confidence: 99%

“…In this sense, formulations comprising CUR-loaded PLGA NPs have recently promoted: (i) increase in bone regeneration in implanted areas in type-2 diabetic mice; 24 (ii) decrease in the Aβ plaques aggregation, which is directly associated to inflammatory processes of the Alzheimer's disease; 25 (iii) anti-COVID-19 activities; 26 (iv) anticancer activities against some of the most dangerous types of tumors, such as liver, brain, and chemoresistant breast cancer; 27−29 (v) anti-atherosclerotic activity; 30 and (vi) reversal of corticosteroid resistance in smokers. 31 Nevertheless, the majority of studies published on CUR encapsulation focus mainly on its therapeutic effects, willing to improve its pharmacokinetics and systemic bioavailability with respect to specific situations, with particular conditions that not necessarily converge to similar techniques. In turn, there is a lack of studies on the stability of CUR throughout the preparation of NPs, as well as on the optimization of process conditions involved in the encapsulation procedure.…”

Section: Introductionmentioning

confidence: 99%

Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance

Feltrin

D'Angelo

Guarnieri

et al. 2023

ACS Appl. Mater. Interfaces

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Curcumin (CUR) is one natural bioactive compound acknowledged for diverse therapeutic activities, but its use is hindered by its poor bioavailability, fast metabolism, and susceptibility to pH variations and light exposure. Thus, the encapsulation in poly(lactic-co-glycolic acid), or PLGA, has been successfully used to protect and enhance CUR absorption in the organism, making CUR-loaded PLGA nanoparticles (NPs) promising drug delivery systems. However, few studies have focused beyond CUR bioavailability, on the environmental variables involved in the encapsulation process, and whether they could help obtain NPs of superior performance. Our study evaluated pH (3.0 or 7.0), temperature (15 or 35 °C), light exposure, and inert atmosphere (N2) incidence in the encapsulation of CUR. The best outcome was at pH 3.0, 15 °C, without light incidence, and without N2 usage. This best nanoformulation showed NP size, zeta potential, and encapsulation efficiency (EE) of 297 nm, −21 mV, and 72%, respectively. Moreover, the CUR in vitro release at pH values 5.5 and 7.4 suggested different potential applications for these NPs, one of which was demonstrated by the effective inhibition of multiple bacteria (i.e., Gram-negative, Gram-positive, and multi-resistant) in the minimal inhibition concentration assay. Besides, statistical analyses confirmed a significant impact of temperature on the NP size; in addition, temperature, light, and N2 affected the EE of CUR. Thus, the selection and control of process variables resulted in higher CUR encapsulation and customizable outcomes, ultimately enabling more economical processes and providing future scale-up guidelines.

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“…As the basic unit of structure and the function of organisms, rat tracheal epithelial (RTE) cells are persistent, universal and stable [29]. In general, fully differentiated RTE cells will always remain in a post-differentiated state and their stability as cellular materials for experiments are the basis for ensuring the scientific validity of experimental results.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Theaflavins and Epigallocatechin Gallate against ZnO-NP-Induced Cell Apoptosis In Vitro

et al. 2022

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Zinc oxide nanoparticles (ZnO-NPs) are commonly used in various commercial applications, causing toxic effects on organisms and destroying biodiversity, but information about their protective approaches remains unknown. This study aims to evaluate the protective effects of theaflavins (TFs) and epigallocatechin gallate (EGCG) against ZnO-NP-induced cytotoxicity in rat tracheal epithelial (RTE) cells. Herein, RTE cells were exposed to 100 μg/L ZnO-NPs for 12 h, then treated with 0, 10, 100, and 1000 μg/L TFs or EGCG for another 12 h; subsequently, oxidative stress, inflammation, and apoptosis analyses were conducted. Relative to the control groups, TFs and EGCG treatment significantly inhibited the levels of reactive oxygen species and malondialdehyde content. Exposure to 1000 μg/L TFs or EGCG treatment downregulated cytochrome C gene expression levels by 59.10% and 77.27%; Caspase 3 gene expression by 50.03% and 60.01%; Caspase 8 gene expression by 45.11% and 55.57%; and Caspase 9 gene expression by 51.33% and 66.67%, respectively. Meanwhile, interleukin 1β and interleukin 6, tumor necrosis factor-α, and the other inflammatory chemokines such as C-C motif chemokine 2 and C-X-C motif chemokine 8 expression were all gradually rescued after the addition of TFs or EGCG. These results imply that TFs or EGCG possibly ameliorated ZnO-NPs-induced toxicity through antiapoptotic, antioxidant, and anti-inflammatory effects. This study provides novel approaches which mitigate the emerging nanoparticle pollutant toxicity in organisms, which may potentially slow down the destruction of biodiversity.

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Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract

Cited by 8 publications

References 27 publications

The protective effects of curcumin against cigarette smoke‐induced toxicity: A comprehensive review

The protective effects of curcumin against cigarette smoke‐induced toxicity: A comprehensive review

Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance

Protective Effects of Theaflavins and Epigallocatechin Gallate against ZnO-NP-Induced Cell Apoptosis In Vitro

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