Curcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats

Naserzadeh, Parvaneh; Hafez, Asghar Ashrafi; Abdorahim, Marjan; Abdollahifar, Mohammad‐Amin; Shabani, Ronak; Peirovi, Habiballah; Simchi, A.; Ashtari, Khadijeh

doi:10.1016/j.biopha.2018.09.106

Cited by 25 publications

(14 citation statements)

References 74 publications

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“…Such pharmacological success relies on the phytochemical abilities of acting on many critical pathways, showing anti-inflammatory (Tham et al, 2010), anti-oxidant (Alexandrow et al, 2012), anti-microbial (Moghadamtousi et al, 2014), and anti-apoptotic (Yu et al, 2010; Jaisin et al, 2011) effects, as well as capability to promote stem cell differentiation (Gu et al, 2012; Mujoo et al, 2012; Chen et al, 2014). Effects of curcumin on mitochondrial function have also been reported (Bavarsad et al, 2018; He et al, 2018; Hsiao et al, 2018; Momekova et al, 2018; Naserzadeh et al, 2018) and furthermore, hormetic effects of curcumin are receiving increased attention (Moghaddam et al, 2018). Curcumin pleiotropic activity is due to its chemical structure, and specifically to the o-methoxy phenolic groups (Priyadarsini and Indira, 2014), which are central for chemical reactions.…”

Section: Introductionmentioning

confidence: 99%

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Rocha‐Ferreira

Sisa²,

Bright³

et al. 2019

Front. Physiol.

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Hypoxic-ischemic encephalopathy (HIE) is a major cause of mortality and morbidity in neonates, with an estimated global incidence of 3/1,000 live births. HIE brain damage is associated with an inflammatory response and oxidative stress, resulting in the activation of cell death pathways. At present, therapeutic hypothermia is the only clinically approved treatment available for HIE. This approach, however, is only partially effective. Therefore, there is an unmet clinical need for the development of novel therapeutic interventions for the treatment of HIE. Curcumin is an antioxidant reactive oxygen species scavenger, with reported anti-tumor and anti-inflammatory activity. Curcumin has been shown to attenuate mitochondrial dysfunction, stabilize the cell membrane, stimulate proliferation, and reduce injury severity in adult models of spinal cord injury, cancer, and cardiovascular disease. The role of curcumin in neonatal HIE has not been widely studied due to its low bioavailability and limited aqueous solubility. The aim of this study was to investigate the effect of curcumin treatment in neonatal HIE, including time of administration and dose-dependent effects. Our results indicate that curcumin administration prior to HIE in neonatal mice elevated cell and tissue loss, as well as glial activation compared to HI alone. However, immediate post-treatment with curcumin was significantly neuroprotective, reducing grey and white matter tissue loss, TUNEL+ cell death, microglia activation, reactive astrogliosis, and iNOS oxidative stress when compared to vehicle-treated littermates. This effect was dose-dependent, with 200 μg/g body weight as the optimal dose-regimen, and was maintained when curcumin treatment was delayed by 60 or 120 min post-HI. Cell proliferation measurements showed no changes between curcumin and HI alone, suggesting that the protective effects of curcumin on the neonatal brain following HI are most likely due to curcumin’s anti-inflammatory and antioxidant properties, as seen in the reduced glial and iNOS activity. In conclusion, this study suggests curcumin as a potent neuroprotective agent with potential for the treatment of HIE. The delayed application of curcumin further increases its clinical relevance.

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Section: Introductionmentioning

confidence: 99%

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Rocha‐Ferreira

Sisa²,

Bright³

et al. 2019

Front. Physiol.

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“…One important substance is erythropoietin, which is used for injuries of the central nervous system and could be used in magnetic nanocarriers to enable rapid targeted delivery within the therapeutic time window by external magnetic navigation [ 533 , 534 ]. Another study showed that curcumin-functionalized IONPs had a strong antineurotoxic activity in the cerebellum of schizophrenic rats [ 535 ].…”

Section: Pns and Cns Regenerationmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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“…These surfactants need further investigation in animal models. Curcumin (diferuloyl methane) is a liposoluble molecule with anti-oxidant, antiapoptotic, anti-inflammatory, and anti-proliferative properties [48,116,117,121]. The neuroprotective efficacy of SPIONs coated by curcumin was studied in the cerebellum of schizophrenic rats [116].…”

Section: Organic Shellsmentioning

confidence: 99%

“…Curcumin (diferuloyl methane) is a liposoluble molecule with anti-oxidant, antiapoptotic, anti-inflammatory, and anti-proliferative properties [48,116,117,121]. The neuroprotective efficacy of SPIONs coated by curcumin was studied in the cerebellum of schizophrenic rats [116]. Curcumin-SPIONs reduced reactive oxygen species formation, increased succinate dehydrogenase activity, and mitochondrial adenosine triphosphate level in comparison to naked SPIONs.…”

Section: Organic Shellsmentioning

confidence: 99%

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Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges

et al. 2021

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Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood–brain and the blood–perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion across these structures. Using superparamagnetic iron oxide nanoparticles (SPIONs), which can be coated to change their properties and ensure biocompatibility, represents a promising tool as a drug carrier. They can act as nanocarriers and can be driven with precision by magnetic forces. The aim of this study was to systematically review the use of SPIONs in the CNS and the inner ear. A systematic PubMed search between 1999 and 2019 yielded 97 studies. In this review, we describe the applications of the SPIONS, their design, their administration, their pharmacokinetic, their toxicity and the methods used for targeted delivery of drugs into the ear and the CNS.

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Curcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats

Cited by 25 publications

References 74 publications

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges

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