Curcumin – Pharmacological Actions And its Role in Oral Submucous Fibrosis: A Review

Alok, Abhijeet; Singh, I. D.; Singh, Shivani; Kishore, Manjari; Jha, Prakash C.

doi:10.7860/jcdr/2015/13857.6552

Cited by 40 publications

(29 citation statements)

References 20 publications

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“…Curcumin, a hydrophobic polyphenol, is extracted from the rhizome of the herb Curcuma longa , which belongs to the Zingiberaceae family [ 33 ]. It has a wide spectrum of biological and pharmacological activities [ 34 ]. Curcumin is less soluble in water and highly soluble in organic solvents including methanol, ethanol, acetone and dimethyl sulfoxide [ 35 ].…”

Section: Curcuminmentioning

confidence: 99%

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

2018

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Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric (Curcuma longa) plant. Curcumin has been demonstrated as an effective therapeutic agent in traditional medicine for the treatment and prevention of different diseases. It has also shown a wide range of biological and pharmacological effects in drug delivery, and has actively been used for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis, neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes, hypertension, chronic kidney diseases, chronic inflammation and infection. The functional application and therapeutic potential of curcumin in the treatment of aging-associated diseases is well documented in the literature. This review article focuses mainly on the potential role of plant-derived natural compounds such as curcumin, their mechanism of action and recent advances in the treatment of aging-associated diseases. Moreover, the review briefly recaps on the recent progress made in the preparation of nanocurcumins and their therapeutic potential in clinical research for the treatment of aging-associated diseases.

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Section: Curcuminmentioning

confidence: 99%

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

2018

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“…The growth, invasion, and metastasis of the cancerous cells can be prevented by curcumin via interfering with their proliferation process [18]. Curcumin scavenges superoxide, nitric oxide, and hydrogen peroxide radicals and reduces the inflammation by lowering the histamine levels and produce an inflammatory response to cytokines [19]. Curcumin also induces apoptosis through the inhibition of cyclooxygenase (COX)–2 and affects various growth factor receptors and molecules involved in tumor growth, angiogenesis, and metastasis [20].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Kong

Kuo

Johnson

et al. 2019

IJMS

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Curcumin, a natural polyphenol extracted from a perennial herb Curcuma longa has been verified for many physiological activities such as anti-oxidant, anti-inflammatory, and anti-tumor properties. The direct use of curcumin cytotoxicity studies are limited due to its unstable chemical structure, low bioavailability, easy oxidation, and degradation by ultraviolet (UV) light etc. Trying to overcome this problem, silica-encapsulated curcumin nanoparticles (SCNP) and chitosan with silica co-encapsulated curcumin nanoparticles (CSCNP) were prepared by silicification and biosilicification methods, respectively, and encapsulated curcumin within it. We investigated the antitumor properties of SCNP and CSCNP on different tumor cell lines. Scanning electron microscopy (SEM) analysis revealed that both SCNP and CSCNP were almost spherical in shape and the average particle size of CSCNP was 75.0 ± 14.62 nm, and SCNP was 61.7 ± 23.04 nm. The results show that CSCNP has more anti-oxidant activity as compared to curcumin and SCNP. The higher cytotoxicity towards different cancerous cell lines was also observed in CSCNP treated tumor cells. It was noted that the SCNP and CSCNP has a high percentage of IC50 values in Hep G2 cells. The encapsulation of curcumin improved instability, antioxidant activity, and antitumor activity. Our results demonstrated that nanoencapsulation of curcumin with silica and chitosan not only increase curcumin stability but also enhance its cytotoxic activity on hepatocellular carcinoma cells. On the basis of these primary studies, the curcumin-loaded nanoparticles appear to be promising as an innovative therapeutic material for the treatment of tumors.

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“…Currently it is being tested for different diseases such as oral cancer, colon cancer, psoriasis, Alzheimer disease, pancreatic cancer, different pre-cancerous conditions. 49 In OSF, it has anti-inflammatory effect and acts by inhibiting various molecules that give their participation in inflammatory reaction and thereby causing fibrinolysis, cellular growth arrest by inhibiting lipid peroxidation which leads to reduction of collagen synthesis. 50 Curcumin proved it's role in OSF by inhibiting the cell proliferation and apoptosis induction which reduces expression of collagen I as well as collagen III 51 .Turmeric oil (TO), turmeric oleoresin (TOR) and turmeric extract (TE) also have therapeutic efficacy in OSF.…”

Section: Curcuminmentioning

confidence: 99%

A Review on Bucco-Adhesive Drug Delivery Systems for Oral Sub-Mucous Fibrosis: Challenges, Opportunities and Future Perspectives

Bhardwaj¹,

Tripathi²,

Mallikarjuna³

et al. 2020

Int Res J Pharm

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Oral sub-mucous fibrosis (OSF) is a chronic, insidious disease which might affect the oral cavity (oral mucosa) including pharynx and larynx. Numerous approaches and anticancer molecules have been explored in the literature to treat OSF with different modes of action. However, complete cure for OSF is limited due to the lack of an ideal carrier for safe and effective delivery of potent drug moieties. There are several challenges such as anatomical or histological barriers and appropriate animal model need to be explored and optimized to develop the efficient treatment for oral sub-mucous fibrosis. Constant progression in the development of new formulations has led to the effective management of the disease associated with the mucosa using mucosal or muco-adhesive drug delivery systems. Muco-adhesive drug delivery systems (such as gel and patches) have gained unique position as drug cargoes. Therefore, present review is an attempt to contemplate on OSF in terms of pathogenesis, currently available treatment shaving their mode of action, major challenges encountered during treatment, usefulness/feasibility of muco-adhesive dosage forms, opportunities/future scope of muco-adhesive drug delivery in OSF and recent developments in the delivery of various anti-cancer drugs in the treatment of OSF.

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Curcumin – Pharmacological Actions And its Role in Oral Submucous Fibrosis: A Review

Cited by 40 publications

References 20 publications

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

A Review on Bucco-Adhesive Drug Delivery Systems for Oral Sub-Mucous Fibrosis: Challenges, Opportunities and Future Perspectives

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