Curcumin polymer coated, self-fluorescent and stimuli-responsive multifunctional mesoporous silica nanoparticles for drug delivery

Xu, Xiubin; Lü, Shaoyu; Wu, Can; Wang, Zhiyong; Chen, Feng; Wen, Ning; Liu, Mingzhu; Zhang, Xinyu; Liu, Zhen; Liu, Yongqi; Ren, Chunzhen

doi:10.1016/j.micromeso.2018.06.009

Cited by 31 publications

(11 citation statements)

References 43 publications

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“…Nanotechnology has been widely investigated for the diagnosis and treatment of diseases, especially for cancer. Ultrasound microbubbles, 1 lipid nanoparticles, 2,3 liposomes, 4 polymer micelles, 5–7 mesoporous silica nanoparticles, 8–10 mesoporous carbon nanoparticles, 11,12 metal oxide nanoparticles, 13–16 and so on have been studied. The conventional nanoscale preparation can be passively ingested into the vascular endothelial space of the tumor and transmits the chemotherapeutic drugs to the tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Gao

Liu

et al. 2019

J Biomater Appl

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Folic acid functionalized gelatin-coated mesoporous hollow carbon nanospheres (FGMCN) were synthesized and applied to enhance the antitumor curative effect of paclitaxel (PTX) for human liver cancer cell lines (SMMC-7721). PTX was loaded in FGMCN by the adsorption method and the PTX-loaded samples (PTX-FGMCN) had a drug content of 29.8 ± 1.06%. The PTX-FGMCN with a sustained release effect was characterized by X-ray diffraction and differential scanning calorimeter in order to analyze the PTX state in FGMCN. In vitro cell experiments showed that FMHSN improves the uptake of PTX and promotes apoptosis due to the nano-targeting effect of FMHSN. An in vivo tumor bearing experiment in mice indicated that the PTX-FGMCN significantly inhibited the growth of tumors. All of these results suggested that the PTX-FGMCN may be an effective anti-hepatoma drug in the future.

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Section: Introductionmentioning

confidence: 99%

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Gao

Liu

et al. 2019

J Biomater Appl

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“…Curcumin polymer was prepared from bis-acrylated curcumin derivative and later coupled to MSNs via thiol-ene coupling reaction in the presence of 3-mercaptopropyltrimethoxysilane (MPTMS) and dithiothreitol (DTT) to impart a reduction sensitive property. The accelerated release of loaded DOX was observed in the presence of glutathione owing to the degradation of curcumin polymer, and the polymer also demonstrated fluorescence imaging capability as evidenced by confocal microscopy [56].…”

Section: Polymer Coated Msns For Imagingmentioning

confidence: 91%

Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

et al. 2019

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Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application.

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“…GSH causes breakage of S─S bonds and thus degradation of the matrix that entrapped the bioactive compounds (Saleh et al, 2018). Through thiolene coupling between 3-mercaptopropyl trimethoxysilane (MPTMS) and bis-acrylate terminated Cur (BCur) to form β-thioester, Xu et al designed a multifunctional mesoporous silica nanoparticle, which could not only be degraded to release the entrapped Cur by reducing agents like GSH but also allow monitoring of cellular uptake efficiency by fluorescent imaging due to the self-fluorescent property of the materials (Xu et al, 2018).…”

Section: Redox-responsive Carriers-functions and Responsive Mechanismsmentioning

confidence: 99%

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

Shishir

Gowd

Suo

et al. 2021

Comp Rev Food Sci Food Safe

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Many important food bioactive compounds are plant secondary metabolites that have traditional applications for health promotion and disease prevention. However, the chemical instability and poor bioavailability of these compounds represent major challenges to researchers. In the last decade, therefore, major impetus has been given for the research and development of advanced carrier systems for the delivery of natural bioactive molecules. Among them, stimuli-responsive carriers hold great promise for simultaneously improving stability, bioavailability, and more importantly delivery and on-demand release of intact bioactive phytochemicals to target sites in response to certain stimuli or combination of them (e.g., pH, temperature, oxidant, enzyme, and irradiation) that would eventually enhance therapeutic outcomes and reduce side effects. Hybrid formulations (e.g., inorganic-organic complexes) and multi-stimuli-responsive formulations have demonstrated great potential for future studies. Therefore, this review systematically compiles and assesses the recent advances on the smart delivery of food bioactive compounds, particularly quercetin, curcumin, and resveratrol through stimuli-responsive carriers, and critically reviews their functionality, underlying triggered-release mechanism, and therapeutic potential. Finally, major limitations, contemporary challenges, and possible solutions/future research directions are highlighted. Much more research is needed to optimize the processing parameters of existing formulations and to develop novel ones for lead food bioactive compounds to facilitate their food and nutraceutical applications.

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Curcumin polymer coated, self-fluorescent and stimuli-responsive multifunctional mesoporous silica nanoparticles for drug delivery

Cited by 31 publications

References 43 publications

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines

Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

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