Curcumin promotes burn wound healing in mice by upregulating caveolin‐1 in epidermal stem cells

Yang, Ronghua; Wang, Jingru; Zhou, Ziheng; Qi, Shunan; Ruan, Shubin; Lin, Zepeng; Qi, Xin; Yang, Lin; Chen, Xiao; Xie, Julin

doi:10.1002/ptr.6238

Cited by 23 publications

(29 citation statements)

References 41 publications

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“…Fourteen studies [ 16 , 28 , 29 , 37 – 39 , 41 , 44 – 50 ] used rats, six studies [ 17 , 30 , 40 , 42 , 43 , 51 ] used mice, and two studies [ 36 , 52 ] used minipigs. A total of 10 studies were conducted in China [ 29 , 30 , 37 , 39 , 40 , 43 , 47 – 49 , 51 ], 3 studies in Brazil [ 16 , 28 , 41 ], 3 studies in the USA [ 36 , 42 , 52 ], and 2 studies in Iran [ 38 , 45 ], whereas the remaining 4 were conducted in Pakistan [ 46 ], Egypt [ 44 ], Turkey [ 50 ], and Canada [ 17 ], respectively. Four studies [ 40 , 43 , 48 , 51 ] did not report burn degree and two [ 38 , 45 ] used second-degree burns, while the others used third-degree.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

Xia

Merwe

et al. 2020

Stem Cell Res Ther

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Background Burns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds. Methods Twenty-two studies with 595 animals were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to 13 May 2020. In addition, a manual search of references of studies was performed to obtain potential studies. No language or time restrictions were enforced. RevMan 5.3 was used for all data analysis. Results The overall meta-analysis showed that stem cell therapy significantly improved burn healing rate (SMD 3.06, 95% CI 1.98 to 4.14), irrespective of transplant type, burn area, and treatment method in the control group. Subgroup analyses indicated that hair follicle stem cells seemed to exert more beneficial effects on animals with burn wounds (SMD 7.53, 95% CI 3.11 to 11.95) compared with other stem cells. Furthermore, stem cell therapy seemed to exert more beneficial effects on burn wounds with second-degree (SMD 7.53, 95% CI 3.11 to 11.95) compared with third-degree (SMD 2.65, 95% CI 1.31 to 4.00). Conclusions Meta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. In general, stem cells can potentially become a novel therapy candidate for burn wounds.

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Section: Resultsmentioning

confidence: 99%

Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

Xia

Merwe

et al. 2020

Stem Cell Res Ther

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“…Application of curcumin prompts an upregulation of Cav-1 expression in these cells. In contrast, genetic ablation of Cav-1 almost completely abrogates the effects of curcumin on cell proliferation and wound closure [73]. This mechanism may be involved in skin improvements observed after topical application of curcumin in different inflammatory skin disorders, including psoriasis and cutaneous wounds.…”

Section: Cav-1 As a Target In A Variety Of Pathological Cutaneous Conmentioning

confidence: 95%

Caveolin as a Universal Target in Dermatology

Kruglikov¹,

Scherer

2019

IJMS

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Caveolin-1 is strongly expressed in different dermal and subdermal cells and physically interacts with signaling molecules and receptors, among them with transforming growth factor beta (TGF-β), matrix metalloproteinases, heat shock proteins, toll-like and glucocorticoid receptors. It should therefore be heavily involved in the regulation of cellular signaling in various hyperproliferative and inflammatory skin conditions. We provide an overview of the role of the caveolin-1 expression in different hyperproliferative and inflammatory skin diseases and discuss its possible active involvement in the therapeutic effects of different well-known drugs widely applied in dermatology. We also discuss the possible role of caveolin expression in development of the drug resistance in dermatology. Caveolin-1 is not only an important pathophysiological factor in different hyperproliferative and inflammatory dermatological conditions, but can also serve as a target for their treatment. Targeted regulation of caveolin is likely to serve as a new treatment strategy in dermatology.

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“…each measurement was repeated three times, with the average value taken as the experiments result. The percentage of wound closure was calculated according to previous reports (9,10,37). it should be noted that the sign of wound closure was defined when the wound bed was re-epithelialized and covered with regenerated tissue.…”

Section: Treatment Of Burn Woundmentioning

confidence: 99%

Long non‑coding RNA HOTAIR promotes burn wound healing by regulating epidermal stem cells

Shi

Yang

et al. 2020

Mol Med Rep

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local transplantation of epidermal stem cells (eScs) exerts a therapeutic effect on burn wounds. However, cell viability can impede their clinical application. HoX antisense intergenic rna (HoTair) is involved in regulating adult tissue stem cells, as well as in developmental patterning and pluripotency. However, little is known about its role in regulating eScs. The present study was performed to investigate the effects of HoTair in the modulation of eScs and wound repair. Firstly, reverse transcription-quantitative Pcr was used to detect the relative expression of HoTair during burn wound healing in mice to determine whether HoTair is associated with wound healing. Subsequently, eScs derived from mouse skin were transfected with a lentiviral vector to overexpress or knockdown HoTair. The effects of HoTair on cell proliferation and differentiation were measured by 5-bromodeoxyuridine and MTT assays, and by assessing nanoG mrna expression. lastly, mice with burns were administered a subcutaneous injection of HoTair-overexpressing eScs. images were captured and histological analyses were performed to evaluate wound healing. The results revealed that the expression of HoTair gradually increased and peaked at day 7 post-burn and maintained at relatively high levels until day 14 post-burn during wound healing. Furthermore, overexpression of HoTair promoted eSc proliferation and maintained the stem cell state in vitro. By contrast, suppression of HoTair inhibited cell proliferation and cell stemness. It was also identified that HoTir-overexpressing eScs accelerated re-epithelialization and facilitated burn wound repair. in conclusion, the present findings confirmed an essential role of HOTAIR in the regulation of eSc proliferation and stemness. Therefore, targeting HoTair in eScs may be a potentially promising therapy for burn wound healing.

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Curcumin promotes burn wound healing in mice by upregulating caveolin‐1 in epidermal stem cells

Cited by 23 publications

References 41 publications

Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

Caveolin as a Universal Target in Dermatology

Long non‑coding RNA HOTAIR promotes burn wound healing by regulating epidermal stem cells

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