Curcumin promotes the spinal cord repair via inhibition of glial scar formation and inflammation

Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar

“…Jin et al [22,30] showed that cur (100 mg/kg) given to animals 7 d after spinal cord hemisection reduced the cytokines TNF-a, IL-1b, and IL-6 expression, suppressed NF-kb signaling pathway activation, and decreased the severity of locomotion deficit. Similarly, cur treatment (50 mg/kg) once daily for 7 d after injury exerted an anti-inflammatory property through NF-kb signaling pathway, decreased glial scar intracellular composition GFAP expression, and improved functional recovery [31]. In this study, we detected by ELISA that inflammationassociated cytokines, such as TNF-a, IL-1b, and NF-kb, were rapidly increased after injury, reaching a peak within 12 h and results showed that 2 wk after injury, the control group presented with the typical structure of loss of spinal cord, and the lesions showed malacia, severe inflammation, and formation of large amounts of vacuolization (indicated by arrows) (A-1), whereas the cur-treatment group showed a significantly clearer structure and significantly reduced inflammation (A-2); the MP-treatment group was intermediate between the mentioned two groups (A-5).…”

Curcumin decreases astrocytic reaction after gliotoxic injury in the rat brainstem

“…Recently, Cur has been shown to exhibit proven therapeutic benefits (including antioxidant, anti-inflammatory, anti-cancer and anti-fibrotic effects) in many pathological conditions, such as Alzheimer' s disease, Parkinson' s disease, multiple sclerosis, epilepsy, cerebral injury, cancer, allergy, asthma, bronchitis, colitis, rheumatoid arthritis, renal ischemia, psoriasis, scleroderma, diabetes, obesity, depression, fatigue and acquired immunodeficiency disease 6,7,8 . Specifically regarding the CNS, Cur was capable of providing neuroprotection after spinal cord injury, inhibiting apoptosis and neuron loss and attenuating oxidative stress in astrocytes and reactive astrogliosis 9,10,11,12,13 , suggesting that Cur might beneficially affect astrocyte population in the CNS inflammatory environment by regulating both NF-κβ and SOX9 signaling pathways 14,15 . In this context, the aim of this study was to evaluate whether Cur had the capacity to affect astrocyte response during the process of demyelination and remyelination following gliotoxic injury induced by ethidium bromide (EB).…”

Modified Bone Marrow Stromal Cells Therapy for Central Nervous System Disorders

“…All these findings demonstrated that Sal B could enhance BMSCs oxidative stress resistance, reducing the H 2 O 2 stimulation caused by cell apoptosis [21]. In other studies, the results indicated that Curcumin could promote the spinal cord repair via inhibition of glialscar formation and inflammation [22,23]. It could block cell injury by virtue of its antioxidant properties [24].…”

“…It could block cell injury by virtue of its antioxidant properties [24]. Curcumin is a double-edgeds word for both JAK2/STAT3 and NF-γB inhibition in injured spinal cord [23].…”