Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice

Chai, Yu-sen; Chen, Yanqing; Lin, Shihui; Xie, Kexin; Wang, Chuanjiang; Yang, Yuanzheng; Xu, Fang

doi:10.1016/j.biopha.2020.109946

Cited by 87 publications

(56 citation statements)

References 52 publications

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“…The anti-inflammatory effect of IL-10 is mediated by metabolic reprogramming of macrophages [62], which is a key event in the inflammatory response, including inhibition of mTOR signalling and inflammasome activation. Study showed that Treg-derived IL-10 is the main factor that could affect macrophage polarization [63]. This may be another IL-10 immune modulation mechanism of PGRN in ARDS.…”

Section: Discussionmentioning

confidence: 91%

Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization

Chen

Wang

Xie

et al. 2020

Mediators of Inflammation

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Progranulin (PGRN), which plays an anti-inflammatory role in acute lung injury (ALI), is promising as a potential drug. Studies have shown that regulatory T cells (Tregs) and interleukin- (IL-) 10 can repress inflammation and alleviate tissue damage during ALI. In this study, we built a lipopolysaccharide- (LPS-) induced ALI mouse model to illustrate the effect of PGRN on regulation of Treg differentiation and modulation of IL-10 promoting macrophage polarization. We found that the proportion of Tregs in splenic mononuclear cells and peripheral blood mononuclear cells was higher after treatment with PGRN. The increased proportion of Tregs after PGRN intratracheal instillation was consistent with the decreased severity of lung injury, the reduction of proinflammatory cytokines, and the increase of anti-inflammatory cytokines. In vitro, the percentages of CD4+CD25+FOXP3+ Tregs from splenic naïve CD4+ T cells increased after PGRN treatment. In further research, it was found that PGRN can regulate the anti-inflammatory factor IL-10 and affect the polarization of M1/M2 macrophages by upregulating IL-10. These findings show that PGRN likely plays a protective role in ALI by promoting Treg differentiation and activating IL-10 immunomodulation.

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Section: Discussionmentioning

confidence: 91%

Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization

Chen

Wang

Xie

et al. 2020

Mediators of Inflammation

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“… Compounds Structure In vitro/in vivo Model (effective dose) Cells (effective concentration) Related pharmacological indicators Related molecular mechanisms Refs. Honokiol 91 CLP/LPS (5 mg/kg) HPMECs (5 μM) MPO↓ TNF-α↓ IL-6↓ MDA↓ iNOS↓ ICAM-1↓ NO↓ HMGB1↓ Activation of Sirt3/AMPK signaling axis [ [283] , [284] , [285] ] Paeonol 92 LPS (0.146 mg/kg) MPO↓ TNF-α↓ IL-1β↓ IL-6↓ HMGB1↓ Inhibition of HMGB1 and TLR4/MyD88/NF-κB signaling pathway [ 286 , 287 ] Magnolol 93 LPS (10 mg/kg) MPO↓ TNF-α↓ IL-1β↓ IL-6↓ COX-2↓ iNOS↓ Activation of PPAR-γ Inhibition of TLR4 mediated NF-kB signaling pathway [ [288] , [289] , [290] , [291] ] Curcumin 94 Bleomycin/LPS/CLP/Lethal gramnegative (150 mg/kg) TNF-α↓ IL-1β↓ IL-6↓ TGF-β↓ HMGB1↓ IL-17A↓ IL-10↑ Inhibition of IL-17A mediated p53-fibrinolytic system, PPARγ/HO1 regulated-HMGB1/RAGE, MAPK signaling pathway, TGF-β1/SMAD3 signaling pathway and NF-κB pathways [ [292] , [293] , [294] , [295] , [296] , [297] , [298] ] Zingerone 95 LPS (20 mg/kg) RAW 264.7 (12.5 μg/mL) MPO↓ TNF-α↓ IL-1β↓ IL-6↓ Inhibition of NF-κB and MAPK signaling pathways [ 299 ] Octyl gallate 96 ...…”

Section: Mechanisms Involved In Ali/ardsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

248

121

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“…In contrast to its negative effect on pro-inflammatory molecules, curcumin has been shown to regulate anti-inflammatory cytokines positively, in particular IL-10 (Larmonier et al, 2008;Chen et al, 2018;Mollazadeh et al, 2019;Chai et al, 2020). The latter is an essential negative regulator for inflammatory responses and is secreted by the dendritic cells that bind to DAMP released from damaged cells during aseptic or antigenic inflammatory reactions.…”

Section: Regulation Of Anti-inflammatory Cytokinesmentioning

confidence: 99%

“…Many studies have revealed that curcumin and curcuminoids potently increase the expression, production, and activity of IL-10 (Larmonier et al, 2008;Chen et al, 2018;Mollazadeh et al, 2019;Chai et al, 2020). Chai et al (2020) have depicted the effect of curcumin on ALI/ARDS using cecal ligation and puncture (CLP)-induced ALI mouse model. In this study, curcumin noticeably attenuates lung injury by inducing the differentiation of regulatory T cells (Tregs) and upregulating IL-10 production.…”

Section: Regulation Of Anti-inflammatory Cytokinesmentioning

confidence: 99%

The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia

Liu

Ying

2020

Front. Cell Dev. Biol.

126

120

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Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting diseases that can be fatal because of lung failure and systemic cytokine storm. The development of coronavirus-evoked pneumonia is associated with excessive inflammatory responses in the lung, known as "cytokine storms," which results in pulmonary edema, atelectasis, and acute lung injury (ALI) or fatal acute respiratory distress syndrome (ARDS). No drugs are available to suppress overly immune responsemediated lung injury effectively. In light of the low toxicity and its antioxidant, antiinflammatory, and antiviral activity, it is plausible to speculate that curcumin could be used as a therapeutic drug for viral pneumonia and ALI/ARDS. Therefore, in this review, we summarize the mounting evidence obtained from preclinical studies using animal models of lethal pneumonia where curcumin exerts protective effects by regulating the expression of both pro-and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of PMN cells, and scavenging the reactive oxygen species (ROS), which exacerbates the inflammatory response. These studies provide a rationale that curcumin can be used as a therapeutic agent against pneumonia and ALI/ARDS in humans resulting from coronaviral infection.

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Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice

Cited by 87 publications

References 52 publications

Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization

Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia

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