Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-κB pathway

Mu, Ying-Tao; Feng, Huanhuan; Yu, Jun; Liu, Zhen-Kai; Wang, Yan; Shao, Jie; Li, Ranhui; Li, De-Kun

doi:10.1007/s10792-020-01406-4

Cited by 12 publications

(6 citation statements)

References 31 publications

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“…Retinoblastoma (Rb) is one of the most common intraocular malignancies in children due to mutations in the oncogene RB1, which accounts for approximately 4% of all pediatric malignancies [ 1 , 2 ]. Currently, protection of the ocular body, improvement of visual acuity, and prevention of metastatic disease are the main treatments for RB.…”

Section: Introductionmentioning

confidence: 99%

Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

Wen

Xiong

2021

Journal of Healthcare Engineering

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Retinoblastoma (RB) is one of the most common intraocular malignancies in children, which causes vision loss and even threatens life. Eriodictyol is a natural flavonoid with strong anticancer activity. Some studies have shown that eriodictyol exerts anticancer effects in glioma, colon cancer, and lung cancer; however, no studies have reported the anticancer effects of eriodictyol on RB. Therefore, the aim of this study was to investigate the anticancer activity of eriodictyol against the RB Y79 cell line and its potential mechanism of action. Interestingly, we found that eriodictyol inhibited the proliferation, migration, and invasion of Y79 cells in a dose-dependent manner and decreased the expression of MMP-2 and MMP-9 proteins in the cells. In addition, eriodictyol-induced apoptosis in Y79 cells was assessed by flow cytometry and immunoblotting. Here, our study revealed that eriodictyol dose dependently inhibited the activation of the PI3K/Akt signaling pathway. Notably, the effect of eriodictyol on RB apoptosis was reversed by a PI3K agonist 740 Y-P. In conclusion, our study shows that eriodictyol effectively inhibits proliferation, migration, and invasion and induces apoptosis in RB cell lines, which may be the result of blocking the PI3K/Akt signaling pathway. Thus, eriodictyol may provide a new theoretical basis for exploring targeted antitumor natural therapies.

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Section: Introductionmentioning

confidence: 99%

Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

Wen

Xiong

2021

Journal of Healthcare Engineering

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“…It was proven that curcuminoids and flavonoids are potent suppressor of MMPs actives and VEGF signalling [267,268]. This suggests that they could suppress the role of exosomes in the formation of the metastases.…”

Section: Effect Of Curcumin and Flavonoid Applications On Emt And Metastasis Formationmentioning

confidence: 99%

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

et al. 2021

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Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death. This review discusses the impact of NSCLC therapy strategies based on a meta-analysis of clinical studies. In addition, possible therapeutic strategies for repression when standard methods fail, such as the administration of low-toxicity natural anticancer agents targeting these phenomena (curcumin and flavonoids), are also discussed. These strategies are presented in the context of key mechanisms of tumour biology with a strong influence on CTC spread and metastasis (mechanisms related to tumour-associated and -infiltrating cells, epithelial–mesenchymal transition, and migration of cancer cells).

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“…A number of mechanisms are responsible for the enhanced expression of MMP-2 and MMP-9 in retinoblastoma, and thus the promotion of proliferation, invasion, migration of retinoblastoma cells: these include Wnt/β-catenin, NF-κB, PI3K, and Akt pathway activation, the upregulation of HMGA2 gene expression, as well as elevated expression of suppressor of Zeste 12 homolog (SUZ12), a component of the polycomb group protein [60][61][62][63][64]. Nevertheless, a decline in MMP production and activity results in significant inhibition of retinoblastoma development and progression [65][66][67][68].…”

Section: Retinoblastomamentioning

confidence: 99%

The Role of Metalloproteinases and Their Tissue Inhibitors on Ocular Diseases: Focusing on Potential Mechanisms

Caban

Owczarek

Lewandowska

2022

IJMS

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Eye diseases are associated with visual impairment, reduced quality of life, and may even lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The unique environment of the eye related to anatomical and physiological barriers and constraints limits the bioavailability of existing agents. In turn, complex ethiopathogenesis of ocular disorders that used drugs generally are non-disease specific and do not act causally. Therefore, there is a need for the development of a new therapeutic and preventive approach. It seems that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have a significant role in the development and progression of eye diseases and could be used in the therapy of these disorders as pharmacological targets. MMPs and TIMPs play an important role in the angiogenesis, epithelial-mesenchymal transition, cell invasion, and migration, which occur in ocular diseases. In this review, we aim to describe the participation of MMPs and TIMPs in the eye diseases, such as age-related macular degeneration, cataract, diabetic retinopathy, dry eye syndrome, glaucoma, and ocular cancers, posterior capsule opacification focusing on potential mechanisms.

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Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-κB pathway

Cited by 12 publications

References 31 publications

Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

The Role of Metalloproteinases and Their Tissue Inhibitors on Ocular Diseases: Focusing on Potential Mechanisms

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