Curcusone D, a novel ubiquitin–proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth

Cao, Mei-Na; Zhou, Yubo; Gao, Anran; Cao, Jiasheng; Gao, Lixin; Li, Sheng; Xu, Lei; Su, Mingbo; Cao, Xianchao; Han, Mengmeng; Wang, Mingkui; Li, Jingya

doi:10.1016/j.bbagen.2014.02.006

Cited by 25 publications

(12 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data also suggest that EAAT3 may regulate the extinction of morphine-induced CPP. This finding is in agreement with our previous results that EAAT3 may regulate learning and memory (Lee et al, 2012; Cao et al, 2014; Wang et al, 2014) and add additional evidence for its role in learning and memory. In addition, our results suggest that EAAT3 can be a target for developing interventions to speed up the recovery from morphine addiction.…”

Section: Discussionsupporting

confidence: 93%

“…Although EAATs that can regulate glutamatergic neurotransmission have been shown to participate in the development of addiction to drugs, such as cocaine (Fujio et al, 2005, Fischer et al, 2013), it is not clear whether EAATs play a role in morphine addiction. Our recent studies have shown that EAAT3, the major neuronal EAAT, may be an important component in the biochemical processes for learning and memory (Lee et al, 2012, Cao et al, 2014, Wang et al, 2014). Thus, EAAT3 may regulate morphine addiction.…”

Section: Discussionmentioning

confidence: 99%

“…Studies from our and other groups have shown that EAAT3, the major neuronal EAAT, participates in the learning and memory processes (Aoyama et al, 2006; Lee et al, 2012; Cao et al, 2014; Wang et al, 2014). Drug addiction is a pathological form of learning and memory related to rewards and cures that predict rewards (Hyman, 2005; Rosen et al, 2015).…”

Section: Introductionmentioning

confidence: 86%

See 2 more Smart Citations

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

Wan

et al. 2017

Neuroscience

View full text Add to dashboard Cite

Glutamate transporters (EAAT) have been implicated in the drug addiction behavior. We determined whether EAAT type 3 (EAAT3) played a role in morphine addiction. Six- to eight-week old EAAT3 knockout (EAAT3−/−) mice and their wild-type littermates received 3 intraperitoneal injections of 10 mg/kg morphine, each on an alternative day, to induce conditioned place preference (CPP). Two days after the place preference returned to baseline, mice received 2.5 mg/kg morphine to induce reinstatement. Some mice received intraperitoneal injection of 4 mg/kg riluzole, an EAAT activator, 30 min before morphine or saline injection. Hippocampus, medial prefrontal cortex, nucleus accumbens and ventral tegmental area were harvested for Western analysis 24 h after the last dose of morphine was injected. Morphine induced CPP in wild-type and EAAT3−/− mice. Gender is not a statistically significant factor to influence this behavior. This conditioned behavior extinguished after morphine administration was stopped for 8 to 9 days in wild-type mice, while this extinction occurred 6 days after discontinuation of morphine injection in EAAT3−/− mice. A small dose of morphine similarly reinstated the conditioned behavior in the wild-type and EAAT3−/− mice. Riluzole abolished morphine-induced CPP during the initial place preference. Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. These results suggest that EAAT3 delays the extinction of morphine-induced CPP. EAAT activation may prevent the formation of morphine-induced CPP.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

Wan

et al. 2017

Neuroscience

View full text Add to dashboard Cite

show abstract

“…6.30) [100]. It was suggested that curcusone D (54) induces reactive oxygen species (ROS), which may correlate with its inhibition of DUBs and the UPS to induce cellular growth inhibition and apoptosis [100]. Investigation of the mechanism of UPS inhibition revealed that curcusone D (54) did not inhibit the proteasome's chymotrypsin-like, trypsin-like, or caspaselike activities, but it reduced the activity of cellular DUBs.…”

Section: Deubiquitinase Inhibitorsmentioning

confidence: 99%

Natural Product Inhibitors of Ubiquitin Conjugation and Deconjugation

Hess

Mackeen

Kramer

2016

Studies in Natural Products Chemistry

View full text Add to dashboard Cite

“…However, if this clearance event is disrupted, immature immunoglobulin would promptly accumulate, which causes cell death eventually [3]. There are two intracellular mechanisms to degrade such harmful proteins after their ubiquitination, namely, ubiquitin-proteasome system (UPS) and autophagy-lysosome system [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma

Zang¹,

Li²,

Liu³

et al. 2015

Cancer Letters

View full text Add to dashboard Cite

Curcusone D, a novel ubiquitin–proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth

Cited by 25 publications

References 46 publications

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

Natural Product Inhibitors of Ubiquitin Conjugation and Deconjugation

Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma

Contact Info

Product

Resources

About