CureCuma–cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity

Spaeth, Andreas; Graeler, Andre; Maisch, Tim; Plaetzer, Kristjan

doi:10.1016/j.ejmech.2017.09.072

Cited by 27 publications

(13 citation statements)

References 56 publications

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“…In terms of structure–activity relationships, methoxy and hydroxyl groups are suggested to play a crucial role in the antimicrobial activity of curcumin . In addition, hydrogen bonding and charge delocalization are the two main physicochemical properties of curcumin for facilitating the interactions with the outer bacterial cell wall . The replacement of these phenolic protons by suitable metals may enhance the antimicrobial activity of curcumin.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Section: Antimicrobial Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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“…The cationic curcumin derivative SACUR-3 ( Fig. 1) 22,24 was kindly provided by Dr Andreas Spaeth (Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany) and dissolved in ultrapure water to a final concentration of 5 mM. The stock solution was stored in the dark at −20°C until usage.…”

Section: Preparation Of Sacur-3 Stock Solutionmentioning

confidence: 99%

New horizons in microbiological food safety: Photodynamic Decontamination based on a curcumin derivative

Glueck

Schamberger

Eckl

et al. 2017

Photochem Photobiol Sci

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Outbreaks of foodborne diseases are regularly reported worldwide. In particular, uncooked plant food is considered risky in terms of microbiological safety. Food is also the most important transmission route for resistant microorganisms from animals to humans. Photodynamic Decontamination (PDc) of foodstuff was recently introduced as a novel approach for increasing microbiological food safety. We investigated the efficiency of PDc on plant food with different geometries (flat, spherical and complex) using a two-dimensional LED array as a light source (435 nm, 33.8 J cm) and the cationic curcumin derivative SACUR-3 as a photosensitiser. A photoantibacterial effect (>3 log CFU reduction) was achieved on all flat substrates (slices of cucumber, tomato and lettuce) with 10 μM, 50 μM or 100 μM SACUR-3. The maximal photokilling with a relative inactivation of 5.6 log was measured on lettuce using 50 μM of the photoactive compound. Phototreatment of non-germinated fenugreek seeds and mung beans was successful if the spherical objects were rotated while under illumination (antibacterial effect at 100 μM SACUR-3). The decontamination of mung bean germlings with a more complex geometry using the PDc approach was ineffective with the two-dimensional light source. In conclusion, PDc based on the cationic curcumin derivative SACUR-3 is very effective at improving the microbiological safety of plant food with a flat or spherical geometry. More complex objects will require the development of novel illumination devices.

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“…Hydrogen peroxide and hydroxyl radical are the others main ROS that curcumin-derived photolytically produces [ 192 ], acting accordingly to Type I mechanism [ 96 ]. Important to highlight that have been reported chemical modification in curcumin structure, as the addition of positive charges, to overcome its hydrophobicity [ 193 ].…”

Section: Bio-effects Of Apdt and Pefmentioning

confidence: 99%

Antimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields

Melo

Celiešiūtė-Germanienė

Šimonis

et al. 2021

Virulence

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Currently, microbial biofilms have been the cause of a wide variety of infections in the human body, reaching 80% of all bacterial and fungal infections. The biofilms present specific properties that increase the resistance to antimicrobial treatments. Thus, the development of new approaches is urgent, and antimicrobial photodynamic therapy (aPDT) has been shown as a promising candidate. aPDT involves a synergic association of a photosensitizer (PS), molecular oxygen and visible light, producing highly reactive oxygen species (ROS) that cause the oxidation of several cellular components. This therapy attacks many components of the biofilm, including proteins, lipids, and nucleic acids present within the biofilm matrix; causing inhibition even in the cells that are inside the extracellular polymeric substance (EPS). Recent advances in designing new PSs to increase the production of ROS and the combination of aPDT with other therapies, especially pulsed electric fields (PEF), have contributed to enhanced biofilm inhibition. The PEF has proven to have antimicrobial effect once it is known that extensive chemical reactions occur when electric fields are applied. This type of treatment kills microorganisms not only due to membrane rupture but also due to the formation of reactive compounds including free oxygen, hydrogen, hydroxyl and hydroperoxyl radicals. So, this review aims to show the progress of aPDT and PEF against the biofilms, suggesting that the association of both methods can potentiate their effects and overcome biofilm infections.

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CureCuma–cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity

Cited by 27 publications

References 56 publications

Biological properties of metal complexes of curcumin

Biological properties of metal complexes of curcumin

New horizons in microbiological food safety: Photodynamic Decontamination based on a curcumin derivative

Antimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields

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