Curing the pandemic of misinformation on COVID-19 mRNA vaccines through real evidence-based medicine - Part 1

Abstract

Background: In response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several new pharmaceutical agents have been administered to billions of people worldwide, including the young and healthy at little risk from the virus. Considerable leeway has been afforded in terms of the pre-clinical and clinical testing of these agents, despite an entirely novel mechanism of action and concerning biodistribution characteristics.Aim: To gain a better understanding of the true benefits and potential harms of the messenger ribonucleic acid (mRNA) coronavirus disease (COVID) vaccines.Methods: A narrative review of the evidence from randomised trials and real world data of the COVID mRNA products with special emphasis on BionTech/Pfizer vaccine.Results: In the non-elderly population the “number needed to treat” to prevent a single death runs into the thousands. Re-analysis of randomised controlled trials using the messenger ribonucleic acid (mRNA) technology suggests a greater risk of serious adverse events from the vaccines than being hospitalised from COVID-19. Pharmacovigilance systems and real-world safety data, coupled with plausible mechanisms of harm, are deeply concerning, especially in relation to cardiovascular safety. Mirroring a potential signal from the Pfizer Phase 3 trial, a significant rise in cardiac arrest calls to ambulances in England was seen in 2021, with similar data emerging from Israel in the 16–39-year-old age group.Conclusion: It cannot be said that the consent to receive these agents was fully informed, as is required ethically and legally. A pause and reappraisal of global vaccination policies for COVID-19 is long overdue.Contribution: This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.

COVID-19 Vaccination Did Not Increase the Risk of Potentially Related Serious Adverse Events: 18-Month Cohort Study in an Italian Province

“…While the effectiveness of these vaccines against severe COVID-19 has been documented in several population studies [ 2 , 3 , 4 , 5 , 6 ], some primary studies [ 7 , 9 , 10 , 11 , 23 ] and secondary analyses of serious adverse events reported (a) in the randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines in adults [ 16 , 24 ], (b) in the U.S.A. Vaccine Adverse Event Reporting System (VAERS) passive surveillance data [ 25 , 26 ], and (c) in the National registries of Denmark, Finland, and Norway [ 27 ], have raised concerns about the safety or risk-benefit profile of COVID-19 vaccination, especially in population subsets with the lowest infection-fatality rate [ 28 ].…”

Curing the pandemic of misinformation on COVID-19 mRNA vaccines through real evidence-based medicine - Part 2

“…It is instructive to note that the greater the financial interests in a given field, the less likely the research findings are to be true. 14 As has been already demonstrated in Part 1 15 of this article, mandating a novel emergency use authorisation vaccine to non-vulnerable people has little to no effect on preventing infection and serious illness, therefore does not have any scientific validity, and therefore breaches the principles of informed consent. It does, however, dramatically enhance the profits of the manufacturer.…”

Public Health Needs the Public Trust: A Pandemic Retrospective

“…Another driver of people's move towards distrust of science has been the experience of adverse events following administration of products known as COVID-19 vaccines. The adverse event rate is significantly higher than any previously administered vaccine, and is even much higher than the rates of vaccines previously withdrawn due to safety concerns [123]. Dangers being assuaged away by public health agency without sufficient evidentiary basis to rule out these dangers violates the bedrock bioethical principle of informed consent [124].…”