2022
DOI: 10.3390/bios12050357
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Current Advancements and Future Road Map to Develop ASSURED Microfluidic Biosensors for Infectious and Non-Infectious Diseases

Abstract: Better diagnostics are always essential for the treatment and prevention of a disease. Existing technologies for detecting infectious and non-infectious diseases are mostly tedious, expensive, and do not meet the World Health Organization’s (WHO) ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end user) criteria. Hence, more accurate, sensitive, and faster diagnostic technologies that meet the ASSURED criteria are highly required for timely and evid… Show more

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Cited by 23 publications
(18 citation statements)
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“…This property of PDMS made it widely popular for fabricating microfluidic devices that strongly impacted biological, biomedical, and engineering research at the turn of this century. [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] Employing inexpensive 1-cm polystyrene cuvettes with four polished sides as moulds allow us to prepare PDMS blocks that perfectly fit into the 1-cm sample holders of most spectrophotometers and spectrofluorometers. After pouring it into the polystyrene cuvettes and degassing it under vacuum, the prepolymer mixture (PDMS, SYLGARDt 184) solidifies at room temperature in less than 24 hours (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This property of PDMS made it widely popular for fabricating microfluidic devices that strongly impacted biological, biomedical, and engineering research at the turn of this century. [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] Employing inexpensive 1-cm polystyrene cuvettes with four polished sides as moulds allow us to prepare PDMS blocks that perfectly fit into the 1-cm sample holders of most spectrophotometers and spectrofluorometers. After pouring it into the polystyrene cuvettes and degassing it under vacuum, the prepolymer mixture (PDMS, SYLGARDt 184) solidifies at room temperature in less than 24 hours (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Microfluidic chips have made a significant contribution to non‐infectious disorders. The most prevalent non‐infectious illnesses, including diabetes, cancer, [148] and cardiovascular (CVD) disorders, have been made detectable via microfluidic chips [149] . The utilization of several pyrrole‐based compounds as potent molecules for the treatment of various non‐infectious disorders is covered in the subsections which follow [150]…”
Section: Pyrroles For Non‐infectious Diseasesmentioning
confidence: 99%
“…These tests are simple to use, rapid, cost-effective, and can be applied directly at the POC. [9][10][11] One of the techniques commonly used for diagnosing COVID-19 biomarkers is the traditional enzyme-linked immunosorbent assay (ELISA). This method detects the viral spike (S) protein and/or nucleocapsid (N) protein by interacting with specic recognition biomolecules.…”
Section: Introductionmentioning
confidence: 99%